Literature DB >> 23848502

Tunable thioesters as "reduction" responsive functionality for traceless reversible protein PEGylation.

Jianwei Chen1, Mingkun Zhao, Fude Feng, Antons Sizovs, Jin Wang.   

Abstract

Disulfide has been the only widely used functionality to serve as a reduction responsive trigger in drug delivery. We introduce thioester as a novel thiol responsive chemistry for drug delivery, whose reactivity can be conveniently modulated by choosing the appropriate steric environment around the thioester. Compared with disulfides, thioesters are facile to synthesize and have an order of magnitude broader kinetic tunability. A novel traceless reversible protein PEGylation reagent is developed based on thioester chemistry.

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Year:  2013        PMID： 23848502     DOI： 10.1021/ja405261u

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  10 in total

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8.  Biocompatibility and Physiological Thiolytic Degradability of Radically Made Thioester-Functional Copolymers: Opportunities for Drug Release.

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Review 9.  Bioresponsive Polymers for Nanomedicine-Expectations and Reality!

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Review 10.  Peptide-Drug Conjugates and Their Targets in Advanced Cancer Therapies.

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  10 in total

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