Literature DB >> 23843586

Cancer antigen 125 as a biomarker in peritoneal dialysis: mesothelial cell health or death?

Harpaul Cheema1, Joanne M Bargman.   

Abstract

The concentration or appearance rate of cancer antigen 125 (CA125) in peritoneal dialysis (PD) effluent has been used for many years as a biomarker for mesothelial cell mass in patients on PD. However, this marker has limitations, and emerging evidence has raised doubts as to its significance. This review explores our current understanding of CA125, its prominent role in studies of "biocompatible" PD solutions, and the ongoing uncertainty concerning its interpretation as a measure of mesothelial cell health.

Entities:  

Keywords:  CA125; Cancer antigen 125; biocompatibility; biomarkers; mesothelial cell mass; peritonitis

Mesh：

Substances：

Year:  2013        PMID： 23843586      PMCID： PMC3707709          DOI： 10.3747/pdi.2012.00320

Source DB:  PubMed          Journal:  Perit Dial Int        ISSN： 0896-8608            Impact factor:   1.756


  24 in total

1.  Acute metabolic effects of dialysis fluids during CAPD.

Authors:  J Delarue; C Maingourd
Journal:  Am J Kidney Dis       Date:  2001-01       Impact factor: 8.860

Review 2.  Dialysate cancer antigen 125 concentration as marker of peritoneal membrane status in patients treated with chronic peritoneal dialysis.

Authors:  R T Krediet
Journal:  Perit Dial Int       Date:  2001 Nov-Dec       Impact factor: 1.756

3.  Benefits of biocompatible PD fluid for preservation of residual renal function in incident CAPD patients: a 1-year study.

Authors:  Sejoong Kim; Jieun Oh; Suhnggwon Kim; Wookyung Chung; Curie Ahn; Sung Gyun Kim; Kook-Hwan Oh
Journal:  Nephrol Dial Transplant       Date:  2009-03-03       Impact factor: 5.992

4.  Long-term clinical effects of a peritoneal dialysis fluid with less glucose degradation products.

Authors:  B Rippe; O Simonsen; O Heimbürger; A Christensson; B Haraldsson; G Stelin; L Weiss; F D Nielsen; S Bro; M Friedberg; A Wieslander
Journal:  Kidney Int       Date:  2001-01       Impact factor: 10.612

5.  Bicarbonate/lactate-based peritoneal dialysis solution increases cancer antigen 125 and decreases hyaluronic acid levels.

Authors:  S Jones; C J Holmes; R T Krediet; R Mackenzie; D Faict; A Tranaeus; J D Williams; G A Coles; N Topley
Journal:  Kidney Int       Date:  2001-04       Impact factor: 10.612

6.  Longitudinal follow-up of CA125 in peritoneal effluent.

Authors:  M M Ho-dac-Pannekeet; J K Hiralall; D G Struijk; R T Krediet
Journal:  Kidney Int       Date:  1997-03       Impact factor: 10.612

7.  The Euro-Balance Trial: the effect of a new biocompatible peritoneal dialysis fluid (balance) on the peritoneal membrane.

Authors:  John D Williams; Nicholas Topley; Kathrine J Craig; Ruth K Mackenzie; Monika Pischetsrieder; Cristina Lage; Jutta Passlick-Deetjen
Journal:  Kidney Int       Date:  2004-07       Impact factor: 10.612

8.  Cancer antigen 125: a bulk marker for the mesothelial mass in stable peritoneal dialysis patients.

Authors:  C E Visser; J J Brouwer-Steenbergen; M G Betjes; G C Koomen; R H Beelen; R T Krediet
Journal:  Nephrol Dial Transplant       Date:  1995       Impact factor: 5.992

9.  Glucose degradation products (GDP) retard remesothelialization independently of D-glucose concentration.

Authors:  Llinos W Morgan; Anders Wieslander; Malcolm Davies; Takashi Horiuchi; Yuji Ohta; M Janine Beavis; Kathryn J Craig; John D Williams; Nicholas Topley
Journal:  Kidney Int       Date:  2003-11       Impact factor: 10.612

10.  Biocompatibility pattern of a bicarbonate/lactate-buffered peritoneal dialysis fluid in APD: a prospective, randomized study.

Authors:  Andreas Fusshoeller; Marcus Plail; Bernd Grabensee; Joerg Plum
Journal:  Nephrol Dial Transplant       Date:  2004-06-22       Impact factor: 5.992
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  9 in total

1.  Re: Cancer antigen 125 as a biomarker in peritoneal dialysis: mesothelial cell health or death?

Authors:  J M Bargman
Journal:  Perit Dial Int       Date:  2013 Nov-Dec       Impact factor: 1.756

2.  Cancer antigen 125 as a biomarker in peritoneal dialysis: mesothelial cell health or death?

Authors:  R T Krediet
Journal:  Perit Dial Int       Date:  2013 Nov-Dec       Impact factor: 1.756

3.  Peritonitis in the patient on peritoneal dialysis: does the composition of the dialysis fluid make a difference?

Authors:  Danica Lam; Joanne M Bargman
Journal:  Clin J Am Soc Nephrol       Date:  2013-08-15       Impact factor: 8.237

4.  Increased storage and secretion of phosphatidylcholines by senescent human peritoneal mesothelial cells.

Authors:  Maria Bartosova; Andras Rudolf; Sebastian Pichl; Kathrin Schmidt; Jürgen G Okun; Beate K Straub; Rafael Rutkowski; Janusz Witowski; Claus P Schmitt
Journal:  Clin Exp Nephrol       Date:  2015-11-02       Impact factor: 2.801

5.  Multiple extracellular vesicle types in peritoneal dialysis effluent are prominent and contain known biomarkers.

Authors:  Lachlan James Pearson; I-Yanut Klaharn; Bussakorn Thongsawang; Wasin Manuprasert; Thunvarat Saejew; Poorichaya Somparn; Piyatida Chuengsaman; Talerngsak Kanjanabuch; Trairak Pisitkun
Journal:  PLoS One       Date:  2017-06-08       Impact factor: 3.240

6.  Microparticle Formation in Peritoneal Dialysis: A Proof of Concept Study.

Authors:  Shareef Akbari; Rima Abou-Arkoub; Suzy Sun; Swapnil Hiremath; Arkadiy Reunov; Brendan B McCormick; Marcel Ruzicka; Dylan Burger
Journal:  Can J Kidney Health Dis       Date:  2017-03-22

7.  Diagnostic and prognostic role of peritoneal CA 125 in peritoneal dialysis patients presenting with acute peritonitis.

Authors:  Kwanpeemai Panorchan; Andrew Davenport
Journal:  BMC Nephrol       Date:  2014-09-12       Impact factor: 2.388

8.  Selective Blocking of TNF Receptor 1 Attenuates Peritoneal Dialysis Fluid Induced Inflammation of the Peritoneum in Mice.

Authors:  Florian Kälble; Janine Damaske; Danijela Heide; Iris Arnold; Fabian Richter; Olaf Maier; Ulrich Eisel; Peter Scheurich; Klaus Pfizenmaier; Martin Zeier; Vedat Schwenger; Julia Ranzinger
Journal:  PLoS One       Date:  2016-10-18       Impact factor: 3.240

9.  Elevated expression of HDAC6 in clinical peritoneal dialysis patients and its pathogenic role on peritoneal angiogenesis.

Authors:  Yingfeng Shi; Jun Ni; Min Tao; Xiaoyan Ma; Yi Wang; Xiujuan Zang; Yan Hu; Andong Qiu; Shougang Zhuang; Na Liu
Journal:  Ren Fail       Date:  2020-11       Impact factor: 2.606
  9 in total

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