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Literature DB >> 23842644

DNA helicases involved in DNA repair and their roles in cancer.

Abstract

Helicases have major roles in genome maintenance by unwinding structured nucleic acids. Their prominence is marked by various cancers and genetic disorders that are linked to helicase defects. Although considerable effort has been made to understand the functions of DNA helicases that are important for genomic stability and cellular homeostasis, the complexity of the DNA damage response leaves us with unanswered questions regarding how helicase-dependent DNA repair pathways are regulated and coordinated with cell cycle checkpoints. Further studies may open the door to targeting helicases in order to improve cancer treatments based on DNA-damaging chemotherapy or radiation.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
DNA Helicases

Year: 2013 PMID： 23842644 PMCID： PMC4538698 DOI： 10.1038/nrc3560

Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716

229 in total

1. Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks.

Authors: Kohei Nishimura; Masamichi Ishiai; Kazuki Horikawa; Tatsuo Fukagawa; Minoru Takata; Haruhiko Takisawa; Masato T Kanemaki
Journal: Mol Cell Date: 2012-07-05 Impact factor: 17.970

2. BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ.

Authors: Rachel Litman; Min Peng; Zhe Jin; Fan Zhang; Junran Zhang; Simon Powell; Paul R Andreassen; Sharon B Cantor
Journal: Cancer Cell Date: 2005-09 Impact factor: 31.743

3. Stimulation of flap endonuclease-1 by the Bloom's syndrome protein.

Authors: Sudha Sharma; Joshua A Sommers; Leonard Wu; Vilhelm A Bohr; Ian D Hickson; Robert M Brosh
Journal: J Biol Chem Date: 2003-12-19 Impact factor: 5.157

4. WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.

Authors: Lishan Chen; Shurong Huang; Lin Lee; Albert Davalos; Robert H Schiestl; Judith Campisi; Junko Oshima
Journal: Aging Cell Date: 2003-08 Impact factor: 9.304

5. Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity.

Authors: Sybille Schwendener; Steven Raynard; Shreya Paliwal; Anita Cheng; Radhakrishnan Kanagaraj; Igor Shevelev; Jeremy M Stark; Patrick Sung; Pavel Janscak
Journal: J Biol Chem Date: 2010-03-25 Impact factor: 5.157

6. Purification of proteins associated with specific genomic Loci.

Authors: Jérôme Déjardin; Robert E Kingston
Journal: Cell Date: 2009-01-09 Impact factor: 41.582

7. The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest.

Authors: Julia M Sidorova; Nianzhen Li; Albert Folch; Raymond J Monnat
Journal: Cell Cycle Date: 2008-01-04 Impact factor: 4.534

Review 8. Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

Authors: Shankar Balasubramanian; Laurence H Hurley; Stephen Neidle
Journal: Nat Rev Drug Discov Date: 2011-04 Impact factor: 84.694

9. FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress.

Authors: Yeon-Tae Jeong; Mario Rossi; Lukas Cermak; Anita Saraf; Laurence Florens; Michael P Washburn; Patrick Sung; Carl L Schildkraut; Carl Schildkraut; Michele Pagano
Journal: J Cell Biol Date: 2013-01-14 Impact factor: 10.539

10. Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges.

Authors: Sudha Sharma; Robert M Brosh
Journal: PLoS One Date: 2007-12-12 Impact factor: 3.240

164 in total

1. RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins.

Authors: Prabhat Khadka; Deborah L Croteau; Vilhelm A Bohr
Journal: DNA Repair (Amst) Date: 2015-12-02

2. Redox Chemistry in the Genome: Emergence of the [4Fe4S] Cofactor in Repair and Replication.

Authors: Jacqueline K Barton; Rebekah M B Silva; Elizabeth O'Brien
Journal: Annu Rev Biochem Date: 2019-06-20 Impact factor: 23.643

Review 3. A synopsis on aging-Theories, mechanisms and future prospects.

Authors: João Pinto da Costa; Rui Vitorino; Gustavo M Silva; Christine Vogel; Armando C Duarte; Teresa Rocha-Santos
Journal: Ageing Res Rev Date: 2016-06-25 Impact factor: 10.895

4. Statistical mechanics of a double-stranded rod model for DNA melting and elasticity.

Authors: Jaspreet Singh; Prashant K Purohit
Journal: Soft Matter Date: 2020-08-26 Impact factor: 3.679

Review 5. Clinically Applicable Inhibitors Impacting Genome Stability.

Authors: Anu Prakash; Juan F Garcia-Moreno; James A L Brown; Emer Bourke
Journal: Molecules Date: 2018-05-13 Impact factor: 4.411

6. Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion.

Authors: Xiao Ling Li; Xing Lu; Swetha Parvathaneni; Sven Bilke; Hongen Zhang; Saravanabhavan Thangavel; Alessandro Vindigni; Toshifumi Hara; Yuelin Zhu; Paul S Meltzer; Ashish Lal; Sudha Sharma
Journal: Cell Cycle Date: 2014 Impact factor: 4.534