Literature DB >> 2384088

Covalent modification and metabolic control analysis. Modification to the theorems and their application to metabolic systems containing covalently modifiable enzymes.

J R Small1, D A Fell.   

Abstract

A study of the sensitivity properties of metabolic systems containing covalently modifiable enzymes and cascades has been carried out with the aid of metabolic control analysis. We have considered how the theorems of metabolic control analysis must be modified to take into account covalently modifiable enzymes, and have used these results to investigate the effects of increasing the total amount of modifiable enzyme. The sensitivity of system variables to an effector acting through a covalent-modification cycle has also been investigated.

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Year:  1990        PMID： 2384088     DOI： 10.1111/j.1432-1033.1990.tb19136.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  9 in total

1.  Product dependence and bifunctionality compromise the ultrasensitivity of signal transduction cascades.

Authors:  Fernando Ortega; Luis Acerenza; Hans V Westerhoff; Francesc Mas; Marta Cascante
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-05       Impact factor: 11.205

Review 2.  Metabolic control analysis: a survey of its theoretical and experimental development.

Authors:  D A Fell
Journal:  Biochem J       Date:  1992-09-01       Impact factor: 3.857

3.  Sensitivity analysis of metabolic cascades catalyzed by bifunctional enzymes.

Authors:  Fernando Ortega; Måns Ehrenberg; Luis Acerenza; Hans V Westerhoff; Francesc Mas; Marta Cascante
Journal:  Mol Biol Rep       Date:  2002       Impact factor: 2.316

4.  Introducing total substrates simplifies theoretical analysis at non-negligible enzyme concentrations: pseudo first-order kinetics and the loss of zero-order ultrasensitivity.

Authors:  Morten Gram Pedersen; Alberto Maria Bersani
Journal:  J Math Biol       Date:  2009-03-31       Impact factor: 2.259

5.  On sensitivity amplification in intracellular signaling cascades.

Authors:  Eva Rácz; Boris M Slepchenko
Journal:  Phys Biol       Date:  2008-07-29       Impact factor: 2.583

Review 6.  Network dynamics.

Authors:  Herbert M Sauro
Journal:  Methods Mol Biol       Date:  2009

7.  Metabolic control analysis of respiration in human cancer tissue.

Authors:  Tuuli Kaambre; Vladimir Chekulayev; Igor Shevchuk; Kersti Tepp; Natalja Timohhina; Minna Varikmaa; Rafaela Bagur; Aleksandr Klepinin; Tiia Anmann; Andre Koit; Andrus Kaldma; Rita Guzun; Vahur Valvere; Valdur Saks
Journal:  Front Physiol       Date:  2013-06-28       Impact factor: 4.566

8.  Quantification of the glycogen cascade system: the ultrasensitive responses of liver glycogen synthase and muscle phosphorylase are due to distinctive regulatory designs.

Authors:  Vivek K Mutalik; K V Venkatesh
Journal:  Theor Biol Med Model       Date:  2005-05-20       Impact factor: 2.432

Review 9.  Nitrogen assimilation in Escherichia coli: putting molecular data into a systems perspective.

Authors:  Wally C van Heeswijk; Hans V Westerhoff; Fred C Boogerd
Journal:  Microbiol Mol Biol Rev       Date:  2013-12       Impact factor: 11.056
  9 in total

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