BACKGROUND: Bariatric surgery is the method of choice in the treatment of morbid obesity. Different genotypes of the serotonin transporter gene (5-HTT) are known to impact the prevalence of psychiatric disorders and the psychosocial state in obese individuals. In this study, we examined the influence of the 5-HTTLPR polymorphism on physiologic and psychosocial measures in morbidly obese women after bariatric surgery. METHODS: We investigated women 1-5 years after bariatric surgery using a semi-structured interview and the Beck Depression Inventory, the Moorhead-Ardelt Quality of life questionnaire, the NEO-Five Factor Inventory and a Resilience scale. The 5-HTTLPR polymorphism (s/s, s/l, l/l) was genotyped using mouth swabs. The influence of genotype on outcome variables was analyzed by independent t test and analysis of covariance corrected for possible confounders. RESULTS: 64 women were enrolled in this study between January 2004 and September 2009. Significantly lower quality of life and higher depression, neuroticism and resilience scores were found in homozygous s-allele carriers of the 5-HTTLPR polymorphism than in l-allele carriers. Except for neuroticism, other factors (age, education, year of surgery, weight before surgery and method of surgery) did not affect the results. We found no influence of genotype on weight loss, current weight or weight before surgery. CONCLUSION: Quality of life, mood, and resilience but not weight loss after bariatric surgery are negatively influenced by the s-allele of the 5-HTTLPR polymorphism.
BACKGROUND: Bariatric surgery is the method of choice in the treatment of morbid obesity. Different genotypes of the serotonin transporter gene (5-HTT) are known to impact the prevalence of psychiatric disorders and the psychosocial state in obese individuals. In this study, we examined the influence of the 5-HTTLPR polymorphism on physiologic and psychosocial measures in morbidly obesewomen after bariatric surgery. METHODS: We investigated women 1-5 years after bariatric surgery using a semi-structured interview and the Beck Depression Inventory, the Moorhead-Ardelt Quality of life questionnaire, the NEO-Five Factor Inventory and a Resilience scale. The 5-HTTLPR polymorphism (s/s, s/l, l/l) was genotyped using mouth swabs. The influence of genotype on outcome variables was analyzed by independent t test and analysis of covariance corrected for possible confounders. RESULTS: 64 women were enrolled in this study between January 2004 and September 2009. Significantly lower quality of life and higher depression, neuroticism and resilience scores were found in homozygous s-allele carriers of the 5-HTTLPR polymorphism than in l-allele carriers. Except for neuroticism, other factors (age, education, year of surgery, weight before surgery and method of surgery) did not affect the results. We found no influence of genotype on weight loss, current weight or weight before surgery. CONCLUSION: Quality of life, mood, and resilience but not weight loss after bariatric surgery are negatively influenced by the s-allele of the 5-HTTLPR polymorphism.
Authors: V Abilés; S Rodríguez-Ruiz; J Abilés; C Mellado; A García; A Pérez de la Cruz; M C Fernández-Santaella Journal: Obes Surg Date: 2008-10-29 Impact factor: 4.129
Authors: Beverly H Brummett; Stephen H Boyle; Ilene C Siegler; Cynthia M Kuhn; Allison Ashley-Koch; Charles R Jonassaint; Stephan Züchner; Ann Collins; Redford B Williams Journal: Behav Genet Date: 2007-10-23 Impact factor: 2.805
Authors: Ahmad R Hariri; Venkata S Mattay; Alessandro Tessitore; Bhaskar Kolachana; Francesco Fera; David Goldman; Michael F Egan; Daniel R Weinberger Journal: Science Date: 2002-07-19 Impact factor: 47.728
Authors: J Picot; J Jones; J L Colquitt; E Gospodarevskaya; E Loveman; L Baxter; A J Clegg Journal: Health Technol Assess Date: 2009-09 Impact factor: 4.014
Authors: Annick V Hartstra; Valentina Schüppel; Sultan Imangaliyev; Anouk Schrantee; Andrei Prodan; Didier Collard; Evgeni Levin; Geesje Dallinga-Thie; Mariette T Ackermans; Maaike Winkelmeijer; Stefan R Havik; Amira Metwaly; Ilias Lagkouvardos; Anika Nier; Ina Bergheim; Mathias Heikenwalder; Andreas Dunkel; Aart J Nederveen; Gerhard Liebisch; Giulia Mancano; Sandrine P Claus; Alfonso Benítez-Páez; Susanne E la Fleur; Jacques J Bergman; Victor Gerdes; Yolanda Sanz; Jan Booij; Elles Kemper; Albert K Groen; Mireille J Serlie; Dirk Haller; Max Nieuwdorp Journal: Mol Metab Date: 2020-09-08 Impact factor: 7.422