J Barcroft1, N Dayoub, K J Thong. 1. Edinburgh Assisted Conception Programme, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, UK.
Abstract
PURPOSE: Determine the outcome of embryo cryopreservation in female oncology patients METHODS: The outcomes of IVF/ICSI cycles in oncology patients over 15 years in a University Teaching Hospital. RESULTS: Forty-two oncology patients (mean 31.9 ± 3.9 years) underwent embryo cryopreservation treatment (n = 33 IVF, n = 6 ICSI). Controlled ovarian stimulation with GnRH antagonist protocol (n = 34; 81 %) yielded fewer oocytes than GnRH agonist protocol (n = 8; 19 %) (9.4 ± 6.3 vs. 15.3 ± 8.9; p = 0.04) respectively. There was no significant difference in mean (±SD) duration of ovarian stimulation (11.6 ± 2.6 vs.10.6 ± 2.7), median gonadotrophin dose (1950 vs. 1670 IU), median day 5-6 oestradiol level (1124 vs.1129 pmol/l) or embryo yield (6.2 ± 4.1 vs. 8.8 ± 4.3; p = 0.07) between GnRH antagonist and agonist treatment cycles respectively. Thirty-nine patients cryopreserved embryos and three had their cycle cancelled. During this study period, of those who cryopreserved embryos, 5 patients underwent 9 frozen-thaw cycles (13 %), resulting in 2 live births (1 twin, 1 singleton, live birth rate 22 %). Six patients died (15 %), 3 conceived naturally (8 %) and 2 couples separated (5 %). Fourteen patients discarded their embryos (36 %). Twenty-two patients' (56 %) have embryos remaining in storage. CONCLUSIONS: This study demonstrates that embryo cryopreservation in female oncology patients gives a satisfactory live birth rate. However, there are concerns regarding cost-effectiveness, resulting from high disposal/non-usage of embryos, and further studies are required.
PURPOSE: Determine the outcome of embryo cryopreservation in female oncology patients METHODS: The outcomes of IVF/ICSI cycles in oncology patients over 15 years in a University Teaching Hospital. RESULTS: Forty-two oncology patients (mean 31.9 ± 3.9 years) underwent embryo cryopreservation treatment (n = 33 IVF, n = 6 ICSI). Controlled ovarian stimulation with GnRH antagonist protocol (n = 34; 81 %) yielded fewer oocytes than GnRH agonist protocol (n = 8; 19 %) (9.4 ± 6.3 vs. 15.3 ± 8.9; p = 0.04) respectively. There was no significant difference in mean (±SD) duration of ovarian stimulation (11.6 ± 2.6 vs.10.6 ± 2.7), median gonadotrophin dose (1950 vs. 1670 IU), median day 5-6 oestradiol level (1124 vs.1129 pmol/l) or embryo yield (6.2 ± 4.1 vs. 8.8 ± 4.3; p = 0.07) between GnRH antagonist and agonist treatment cycles respectively. Thirty-nine patients cryopreserved embryos and three had their cycle cancelled. During this study period, of those who cryopreserved embryos, 5 patients underwent 9 frozen-thaw cycles (13 %), resulting in 2 live births (1 twin, 1 singleton, live birth rate 22 %). Six patients died (15 %), 3 conceived naturally (8 %) and 2 couples separated (5 %). Fourteen patients discarded their embryos (36 %). Twenty-two patients' (56 %) have embryos remaining in storage. CONCLUSIONS: This study demonstrates that embryo cryopreservation in female oncology patients gives a satisfactory live birth rate. However, there are concerns regarding cost-effectiveness, resulting from high disposal/non-usage of embryos, and further studies are required.
Authors: Hesham G Al-Inany; Mohamed A F M Youssef; Mohamed Aboulghar; Frank Broekmans; Monique Sterrenburg; Janine Smit; Ahmed M Abou-Setta Journal: Hum Reprod Update Date: 2011 Jul-Aug Impact factor: 15.610
Authors: Barbara Luke; Morton B Brown; Logan G Spector; Judy E Stern; Yolanda R Smith; Melanie Williams; Lori Koch; Maria J Schymura Journal: J Assist Reprod Genet Date: 2016-02-03 Impact factor: 3.412
Authors: Karin Hammarberg; Maggie Kirkman; Catharyn Stern; Robert I McLachlan; Debra Gook; Luk Rombauts; Beverley Vollenhoven; Jane R W Fisher Journal: BMC Health Serv Res Date: 2017-05-10 Impact factor: 2.655
Authors: Zobaida Edib; Yasmin Jayasinghe; Martha Hickey; Lesley Stafford; Richard A Anderson; H Irene Su; Kate Stern; Christobel Saunders; Antoinette Anazodo; Mary Macheras-Magias; Shanton Chang; Patrick Pang; Franca Agresta; Laura Chin-Lenn; Wanyuan Cui; Sarah Pratt; Alex Gorelik; Michelle Peate Journal: BMJ Open Date: 2020-02-10 Impact factor: 2.692