Literature DB >> 23835478

Channel gating pore: a new therapeutic target.

Polina Kornilov1, Asher Peretz, Bernard Attali.   

Abstract

Each subunit of voltage-gated cation channels comprises a voltage-sensing domain and a pore region. In a paper recently published in Cell Research, Li et al. showed that the gating charge pathway of the voltage sensor of the KCNQ2 K+ channel can accommodate small opener molecules and offer a new target to treat hyperexcitability disorders.

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Year:  2013        PMID： 23835478      PMCID： PMC3760620          DOI： 10.1038/cr.2013.89

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  6 in total

1.  Targeting the voltage sensor of Kv7.2 voltage-gated K+ channels with a new gating-modifier.

Authors:  Asher Peretz; Liat Pell; Yana Gofman; Yoni Haitin; Liora Shamgar; Eti Patrich; Polina Kornilov; Orit Gourgy-Hacohen; Nir Ben-Tal; Bernard Attali
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-16       Impact factor: 11.205

Review 2.  Sensing voltage across lipid membranes.

Authors:  Kenton J Swartz
Journal:  Nature       Date:  2008-12-18       Impact factor: 49.962

3.  Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment.

Authors:  Stephen B Long; Xiao Tao; Ernest B Campbell; Roderick MacKinnon
Journal:  Nature       Date:  2007-11-15       Impact factor: 49.962

4.  A gating charge transfer center in voltage sensors.

Authors:  Xiao Tao; Alice Lee; Walrati Limapichat; Dennis A Dougherty; Roderick MacKinnon
Journal:  Science       Date:  2010-04-02       Impact factor: 47.728

5.  The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands.

Authors:  Ping Li; Zhuxi Chen; Haiyan Xu; Haifeng Sun; Hao Li; Hong Liu; Huaiyu Yang; Zhaobing Gao; Hualiang Jiang; Min Li
Journal:  Cell Res       Date:  2013-06-25       Impact factor: 25.617

6.  An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations.

Authors:  Ernesto Vargas; Vladimir Yarov-Yarovoy; Fatemeh Khalili-Araghi; William A Catterall; Michael L Klein; Mounir Tarek; Erik Lindahl; Klaus Schulten; Eduardo Perozo; Francisco Bezanilla; Benoît Roux
Journal:  J Gen Physiol       Date:  2012-12       Impact factor: 4.086
  6 in total
  2 in total

1.  Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects.

Authors:  Qiansen Zhang; Yimin Ren; Yiqing Mo; Peipei Guo; Ping Liao; Yuncheng Luo; Jie Mu; Zhuo Chen; Yang Zhang; Ya Li; Linghui Yang; Daqing Liao; Jie Fu; Juwen Shen; Wei Huang; Xuewen Xu; Yanyan Guo; Lianghe Mei; Yunxia Zuo; Jin Liu; Huaiyu Yang; Ruotian Jiang
Journal:  Cell Res       Date:  2022-02-03       Impact factor: 46.297

Review 2.  Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug Discovery.

Authors:  Paola Imbrici; Antonella Liantonio; Giulia M Camerino; Michela De Bellis; Claudia Camerino; Antonietta Mele; Arcangela Giustino; Sabata Pierno; Annamaria De Luca; Domenico Tricarico; Jean-Francois Desaphy; Diana Conte
Journal:  Front Pharmacol       Date:  2016-05-10       Impact factor: 5.810
  2 in total

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