| Literature DB >> 23831858 |
Ahmed Aied1, Udo Greiser, Abhay Pandit, Wenxin Wang.
Abstract
Recent progress in gene therapy has opened doors for the development of new and multifunctional delivery agents based on the tailored synthesis of polymers. These polymers are in their infancy compared with viral agents, which have been optimised during millions of years of evolution, making viral vectors naturally efficient transfection agents. To improve the efficiency of polymer gene delivery to the level seen in viral vectors, it is necessary to understand the challenges faced by polymer gene delivery vectors both in vitro and in vivo. In this review, we analyse and discuss those obstacles that scientists have to overcome to design a highly efficient synthetic transfection agent.Entities:
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Year: 2013 PMID： 23831858 DOI： 10.1016/j.drudis.2013.06.014
Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851