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Literature DB >> 2382987

Selective over-expression of mRNA coding for 90 KDa stress-protein in human ovarian cancer.

A M Mileo¹, M Fanuele, F Battaglia, G Scambia, P Benedetti-Panici, S Mancuso, U Ferrini.

Abstract

The mRNA expression of the KDa stress-protein (SP) was assayed in normal and neoplastic human ovary. It was found that the expression level is low in normal ovary and in benign tumors and increases in the more advanced stages of ovarian cancer. A low level of mRNA coding for the 70 KDa SP--the most prominent among the inducible SPs-was constantly found in all specimens. No relationship was observed between SP 90 mRNA abundance and the receptor status of epidermal growth factor, estrogen and progesterone.

Entities: Disease Species

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Year: 1990 PMID： 2382987

Source DB: PubMed Journal: Anticancer Res ISSN： 0250-7005 Impact factor: 2.480

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Cited

12 in total

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Selective over-expression of mRNA coding for 90 KDa stress-protein in human ovarian cancer.

Review 1. Geldanamycin: the prototype of a class of antitumor drugs targeting the heat shock protein 90 family of molecular chaperones.

2. The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion.

Review 3. Molecular chaperones in the etiology and therapy of cancer.

4. Genetic prognostic index influences patient outcome for node-positive breast cancer.

5. Ganetespib, a novel Hsp90 inhibitor in patients with KRAS mutated and wild type, refractory metastatic colorectal cancer.

Review 6. Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications.

7. Four-protein model for predicting prognostic risk of lung cancer.

8. Heat-Shock Stress-Response Proteins in Endocrine Pathology.

Review 9. Hsp90, the concertmaster: tuning transcription.

Review 10. Do heat shock proteins have a role in breast cancer?