Literature DB >> 11599571

Geldanamycin: the prototype of a class of antitumor drugs targeting the heat shock protein 90 family of molecular chaperones.

H J Ochel1, K Eichhorn, G Gademann.   

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Year:  2001        PMID： 11599571      PMCID： PMC434387          DOI： 10.1379/1466-1268(2001)006<0105:gtpoac>2.0.co;2

Source DB:  PubMed          Journal:  Cell Stress Chaperones        ISSN： 1355-8145            Impact factor:   3.667


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2.  Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide.

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3.  The charged region of Hsp90 modulates the function of the N-terminal domain.

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4.  A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock.

Authors:  C F Chen; Y Chen; K Dai; P L Chen; D J Riley; W H Lee
Journal:  Mol Cell Biol       Date:  1996-09       Impact factor: 4.272

5.  Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells.

Authors:  L Whitesell; P Cook
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6.  KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules.

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7.  Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

Authors:  M V Blagosklonny; J Toretsky; S Bohen; L Neckers
Journal:  Proc Natl Acad Sci U S A       Date:  1996-08-06       Impact factor: 11.205

8.  Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell.

Authors:  B Sepehrnia; I B Paz; G Dasgupta; J Momand
Journal:  J Biol Chem       Date:  1996-06-21       Impact factor: 5.157

9.  Control of adhesion-dependent cell survival by focal adhesion kinase.

Authors:  S M Frisch; K Vuori; E Ruoslahti; P Y Chan-Hui
Journal:  J Cell Biol       Date:  1996-08       Impact factor: 10.539

10.  The benzoquinone ansamycin geldanamycin stimulates proteolytic degradation of focal adhesion kinase.

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2.  Rapid engineering of the geldanamycin biosynthesis pathway by Red/ET recombination and gene complementation.

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4.  Geldanamycin treatment reduces neovascularization in a mouse model of retinopathy of prematurity.

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5.  Induction of angiogenesis by heat shock protein 90 mediated by protein kinase Akt and endothelial nitric oxide synthase.

Authors:  Jianxin Sun; James K Liao
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6.  Heat shock protein 90-α mediates aldo-keto reductase 1B10 (AKR1B10) protein secretion through secretory lysosomes.

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7.  Glial cell line-derived neurotrophic factor reverses ethanol-mediated increases in tyrosine hydroxylase immunoreactivity via altering the activity of heat shock protein 90.

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8.  Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies.

Authors:  Shivaani Kummar; Martin E Gutierrez; Erin R Gardner; Xiaohong Chen; William D Figg; Maria Zajac-Kaye; Min Chen; Seth M Steinberg; Christine A Muir; Mary Ann Yancey; Yvonne R Horneffer; Lamin Juwara; Giovanni Melillo; S Percy Ivy; Maria Merino; Len Neckers; Patricia S Steeg; Barbara A Conley; Giuseppe Giaccone; James H Doroshow; Anthony J Murgo
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9.  Alcohol exposure regulates heat shock transcription factor binding and heat shock proteins 70 and 90 in monocytes and macrophages: implication for TNF-alpha regulation.

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10.  A functional heat shock protein 90 chaperone is essential for efficient flock house virus RNA polymerase synthesis in Drosophila cells.

Authors:  Kathryn M Castorena; Spencer A Weeks; Kenneth A Stapleford; Amy M Cadwallader; David J Miller
Journal:  J Virol       Date:  2007-05-23       Impact factor: 5.103
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