Literature DB >> 23827705

-Oh no! hiPSCs misplace their 5hmCs.

William E Lowry1.   

Abstract

hiPSCs and hESCs are thought to display subtle genetic and epigenetic variability. Recently in Nature Cell Biology, Wang et al. (2013) demonstrated a role for TET1 during reprogramming of human cells and showed that hiPSCs lack appropriate 5hmC marks in subtelomeric regions, contributing to epigenetic variation common to hiPSCs.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 23827705      PMCID： PMC3753777          DOI： 10.1016/j.stem.2013.06.007

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  10 in total

1.  Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells.

Authors:  Yuki Ohi; Han Qin; Chibo Hong; Laure Blouin; Jose M Polo; Tingxia Guo; Zhongxia Qi; Sara L Downey; Philip D Manos; Derrick J Rossi; Jingwei Yu; Matthias Hebrok; Konrad Hochedlinger; Joseph F Costello; Jun S Song; Miguel Ramalho-Santos
Journal:  Nat Cell Biol       Date:  2011-04-17       Impact factor: 28.824

Review 2.  Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier.

Authors:  Akira Watanabe; Yasuhiro Yamada; Shinya Yamanaka
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2013-01-05       Impact factor: 6.237

3.  Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells.

Authors:  Sergio Ruiz; Dinh Diep; Athurva Gore; Athanasia D Panopoulos; Nuria Montserrat; Nongluk Plongthongkum; Sachin Kumar; Ho-Lim Fung; Alessandra Giorgetti; Josipa Bilic; Erika M Batchelder; Holm Zaehres; Natalia G Kan; Hans Robert Schöler; Mark Mercola; Kun Zhang; Juan Carlos Izpisua Belmonte
Journal:  Proc Natl Acad Sci U S A       Date:  2012-09-18       Impact factor: 11.205

4.  Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells.

Authors:  Kian Peng Koh; Akiko Yabuuchi; Sridhar Rao; Yun Huang; Kerrianne Cunniff; Julie Nardone; Asta Laiho; Mamta Tahiliani; Cesar A Sommer; Gustavo Mostoslavsky; Riitta Lahesmaa; Stuart H Orkin; Scott J Rodig; George Q Daley; Anjana Rao
Journal:  Cell Stem Cell       Date:  2011-02-04       Impact factor: 24.633

5.  Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines.

Authors:  Christoph Bock; Evangelos Kiskinis; Griet Verstappen; Hongcang Gu; Gabriella Boulting; Zachary D Smith; Michael Ziller; Gist F Croft; Mackenzie W Amoroso; Derek H Oakley; Andreas Gnirke; Kevin Eggan; Alexander Meissner
Journal:  Cell       Date:  2011-02-04       Impact factor: 41.582

6.  Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures.

Authors:  Mark H Chin; Mike J Mason; Wei Xie; Stefano Volinia; Mike Singer; Cory Peterson; Gayane Ambartsumyan; Otaren Aimiuwu; Laura Richter; Jin Zhang; Ivan Khvorostov; Vanessa Ott; Michael Grunstein; Neta Lavon; Nissim Benvenisty; Carlo M Croce; Amander T Clark; Tim Baxter; April D Pyle; Mike A Teitell; Matteo Pelegrini; Kathrin Plath; William E Lowry
Journal:  Cell Stem Cell       Date:  2009-07-02       Impact factor: 24.633

7.  TRF1 is a stem cell marker and is essential for the generation of induced pluripotent stem cells.

Authors:  Ralph P Schneider; Ianire Garrobo; Miguel Foronda; Jose A Palacios; Rosa M Marión; Ignacio Flores; Sagrario Ortega; Maria A Blasco
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

8.  Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives.

Authors:  Kristopher L Nazor; Gulsah Altun; Candace Lynch; Ha Tran; Julie V Harness; Ileana Slavin; Ibon Garitaonandia; Franz-Josef Müller; Yu-Chieh Wang; Francesca S Boscolo; Eyitayo Fakunle; Biljana Dumevska; Sunray Lee; Hyun Sook Park; Tsaiwei Olee; Darryl D D'Lima; Ruslan Semechkin; Mana M Parast; Vasiliy Galat; Andrew L Laslett; Uli Schmidt; Hans S Keirstead; Jeanne F Loring; Louise C Laurent
Journal:  Cell Stem Cell       Date:  2012-05-04       Impact factor: 24.633

9.  Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells.

Authors:  Ryan Lister; Mattia Pelizzola; Yasuyuki S Kida; R David Hawkins; Joseph R Nery; Gary Hon; Jessica Antosiewicz-Bourget; Ronan O'Malley; Rosa Castanon; Sarit Klugman; Michael Downes; Ruth Yu; Ron Stewart; Bing Ren; James A Thomson; Ronald M Evans; Joseph R Ecker
Journal:  Nature       Date:  2011-02-02       Impact factor: 49.962

10.  Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency.

Authors:  Tao Wang; Hao Wu; Yujing Li; Keith E Szulwach; Li Lin; Xuekun Li; I-Ping Chen; Ian S Goldlust; Stormy J Chamberlain; Ann Dodd; He Gong; Gene Ananiev; Ji Woong Han; Young-sup Yoon; M Katharine Rudd; Miao Yu; Chun-Xiao Song; Chuan He; Qiang Chang; Stephen T Warren; Peng Jin
Journal:  Nat Cell Biol       Date:  2013-05-19       Impact factor: 28.824
  10 in total

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