OBJECTIVE: To evaluate the possible association between cathepsin Z (CTSZ) rs34069356 C/T (Ala286Thr) and melanocortin-3 receptor (MC3R) rs6127698 G>T (-484 G/T) gene polymorphisms and pulmonary tuberculosis (PTB) in an Iranian sample population. DESIGN: This case-control study included 150 PTB patients and 177 healthy subjects. Tetra amplification refractory mutation system-polymerase chain reaction was used to detect polymorphisms. RESULTS: Our findings revealed that the MC3R rs6127698 TT genotype increased the risk of PTB compared with GG (additive model: OR 2.24, 95%CI 1.13-4.64, P = 0.021) as well as GG+GT (recessive model: OR 1.89, 95%CI 1.13-3.18, P = 0.016). The rs6127698 T allele increased the risk of PTB (OR 1.56, 95%CI 1.14-2.13, P = 0.005) compared to the G allele. The CTSZ rs34069356 polymorphism was not associated with PTB in additive-, dominant- and recessive-tested inheritance models (P > 0.05). CONCLUSION: Our data suggest that MC3R rs6127698, but not CTSZ rs34069356 polymorphism, is associated with PTB in a sample Iranian population.
OBJECTIVE: To evaluate the possible association between cathepsin Z (CTSZ) rs34069356 C/T (Ala286Thr) and melanocortin-3 receptor (MC3R) rs6127698 G>T (-484 G/T) gene polymorphisms and pulmonary tuberculosis (PTB) in an Iranian sample population. DESIGN: This case-control study included 150 PTB patients and 177 healthy subjects. Tetra amplification refractory mutation system-polymerase chain reaction was used to detect polymorphisms. RESULTS: Our findings revealed that the MC3R rs6127698 TT genotype increased the risk of PTB compared with GG (additive model: OR 2.24, 95%CI 1.13-4.64, P = 0.021) as well as GG+GT (recessive model: OR 1.89, 95%CI 1.13-3.18, P = 0.016). The rs6127698 T allele increased the risk of PTB (OR 1.56, 95%CI 1.14-2.13, P = 0.005) compared to the G allele. The CTSZrs34069356 polymorphism was not associated with PTB in additive-, dominant- and recessive-tested inheritance models (P > 0.05). CONCLUSION: Our data suggest that MC3R rs6127698, but not CTSZrs34069356 polymorphism, is associated with PTB in a sample Iranian population.
Authors: Byung Lae Park; Lyoung Hyo Kim; Suhg Namgoong; Ji On Kim; Jason Yongha Kim; Hun Soo Chang; Jong Sook Park; An Soo Jang; Sung Woo Park; Do Jin Kim; Ki Up Kim; Yang Gee Kim; Soo-Taek Uh; Ki Hyun Seo; Young Hoon Kim; Choon Sik Park; Hyoung Doo Shin Journal: Lung Date: 2014-07-27 Impact factor: 2.584
Authors: Jasmine M Olvany; Lindsay N Sausville; Marquitta J White; Alessandra Tacconelli; Gloria Tavera; Rafal S Sobota; Cinzia Ciccacci; Anders S Bohlbro; Christian Wejse; Scott M Williams; Giorgio Sirugo Journal: Infect Genet Evol Date: 2020-09-22 Impact factor: 3.342