Literature DB >> 23826404

The role of TP53 network in the pathogenesis of chronic lymphocytic leukemia.

Cheng Wang1, Xin Wang.   

Abstract

TP53 is one of the most important prognostic factors in chronic lymphocytic leukemia (CLL). Modulation of microRNAs by TP53 in CLL pathogenesis has been a hotspot. Besides, it has an intimate association with other cytogenetics and plays an important part in drug resistance of CLL. All above indicate an embedded TP53-centered network in CLL pathogenesis and prognosis. In this review, we focus on the TP53-centered network and its roles in the pathogenesis of CLL.

Entities:  

Keywords:  TP53 network; chronic lymphocytic leukemia; microRNAs; pathogenesis

Mesh：

Substances：

Year:  2013        PMID： 23826404      PMCID： PMC3693188     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  57 in total

1.  Defective ATM-p53-mediated apoptotic pathway in multiple sclerosis.

Authors:  Xinqing Deng; Asa Ljunggren-Rose; Kevin Maas; Subramaniam Sriram
Journal:  Ann Neurol       Date:  2005-10       Impact factor: 10.422

2.  Missense mutations located in structural p53 DNA-binding motifs are associated with extremely poor survival in chronic lymphocytic leukemia.

Authors:  Martin Trbusek; Jana Smardova; Jitka Malcikova; Ludmila Sebejova; Petr Dobes; Miluse Svitakova; Vladimira Vranova; Marek Mraz; Hana Skuhrova Francova; Michael Doubek; Yvona Brychtova; Petr Kuglik; Sarka Pospisilova; Jiri Mayer
Journal:  J Clin Oncol       Date:  2011-05-23       Impact factor: 44.544

3.  S-MDM4 mRNA overexpression indicates a poor prognosis and marks a potential therapeutic target in chronic lymphocytic leukemia.

Authors:  Ling Liu; Lei Fan; Cheng Fang; Zhi-Jian Zou; Shu Yang; Li-Na Zhang; Jian-Yong Li; Wei Xu
Journal:  Cancer Sci       Date:  2012-10-10       Impact factor: 6.716

4.  Interdependent regulation of p53 and miR-34a in chronic lymphocytic leukemia.

Authors:  Olaf Merkel; Daniela Asslaber; Josefina D Piñón; Alexander Egle; Richard Greil
Journal:  Cell Cycle       Date:  2010-07-03       Impact factor: 4.534

5.  TP53 mutation and survival in chronic lymphocytic leukemia.

Authors:  Thorsten Zenz; Barbara Eichhorst; Raymonde Busch; Tina Denzel; Sonja Häbe; Dirk Winkler; Andreas Bühler; Jennifer Edelmann; Manuela Bergmann; Georg Hopfinger; Manfred Hensel; Michael Hallek; Hartmut Döhner; Stephan Stilgenbauer
Journal:  J Clin Oncol       Date:  2010-08-09       Impact factor: 44.544

Review 6.  From pathogenesis to treatment of chronic lymphocytic leukaemia.

Authors:  Thorsten Zenz; Daniel Mertens; Ralf Küppers; Hartmut Döhner; Stephan Stilgenbauer
Journal:  Nat Rev Cancer       Date:  2009-12-03       Impact factor: 60.716

7.  The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia.

Authors:  Ulf Klein; Marie Lia; Marta Crespo; Rachael Siegel; Qiong Shen; Tongwei Mo; Alberto Ambesi-Impiombato; Andrea Califano; Anna Migliazza; Govind Bhagat; Riccardo Dalla-Favera
Journal:  Cancer Cell       Date:  2010-01-07       Impact factor: 31.743

8.  MDM2 SNP309 variation contributes to leukemia risk: meta-analyses based on 7259 subjects.

Authors:  Wenlei Zhuo; Liang Zhang; Junjun Ling; Bo Zhu; Zhengtang Chen
Journal:  Leuk Lymphoma       Date:  2012-06-12

9.  p53 Family: Role of Protein Isoforms in Human Cancer.

Authors:  Jinxiong Wei; Elena Zaika; Alexander Zaika
Journal:  J Nucleic Acids       Date:  2011-10-09

10.  The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.

Authors:  Zhenyue Hao; Gordon S Duncan; Yu-Wen Su; Wanda Y Li; Jennifer Silvester; Claire Hong; Han You; Dirk Brenner; Chiara Gorrini; Jillian Haight; Andrew Wakeham; Annick You-Ten; Susan McCracken; Andrew Elia; Qinxi Li; Jacqui Detmar; Andrea Jurisicova; Elias Hobeika; Michael Reth; Yi Sheng; Philipp A Lang; Pamela S Ohashi; Qing Zhong; Xiaodong Wang; Tak W Mak
Journal:  J Exp Med       Date:  2012-01-02       Impact factor: 14.307
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  5 in total

1.  Role of miR-15a/miR-16-1 and the TP53 axis in regulating telomerase expression in chronic lymphocytic leukemia.

Authors:  Enrica Rampazzo; Engin Bojnik; Livio Trentin; Laura Bonaldi; Paola Del Bianco; Federica Frezzato; Andrea Visentin; Monica Facco; Gianpietro Semenzato; Anita De Rossi
Journal:  Haematologica       Date:  2017-04-06       Impact factor: 9.941

2.  Metadherin contribute to BCR signaling in chronic lymphocytic leukemia.

Authors:  Pei-Pei Li; Qing-Min Yao; Hui Zhou; Li-Li Feng; Xue-Ling Ge; Xiao Lv; Na Chen; Kang Lu; Xin Wang
Journal:  Int J Clin Exp Pathol       Date:  2014-03-15

3.  Expression of RKIP in chronic myelogenous leukemia K562 cell and inhibits cell proliferation by regulating the ERK/MAPK pathway.

Authors:  Bin Li; Baolan Sun; Jianwei Zhu; Nina Zhou; Zhiping Yang; Jianhui Gu
Journal:  Tumour Biol       Date:  2014-10

4.  Impact Of TP53 Gene Promoter Methylation On Chronic Lymphocytic Leukemia Pathogenesis And Progression.

Authors:  Waleed Haji Saeed; Adil Abozaid Eissa; Adnan Anwar Al-Doski
Journal:  J Blood Med       Date:  2019-11-25

Review 5.  Tumor Suppressors in Chronic Lymphocytic Leukemia: From Lost Partners to Active Targets.

Authors:  Giacomo Andreani; Giovanna Carrà; Marcello Francesco Lingua; Beatrice Maffeo; Mara Brancaccio; Riccardo Taulli; Alessandro Morotti
Journal:  Cancers (Basel)       Date:  2020-03-09       Impact factor: 6.639
  5 in total

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