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Literature DB >> 23824865

PharmGKB: the Pharmacogenomics Knowledge Base.

Caroline F Thorn¹, Teri E Klein, Russ B Altman.

Abstract

The Pharmacogenomics Knowledge Base, PharmGKB, is an interactive tool for researchers investigating how genetic variation affects drug response. The PharmGKB Web site, http://www.pharmgkb.org , displays genotype, molecular, and clinical knowledge integrated into pathway representations and Very Important Pharmacogene (VIP) summaries with links to additional external resources. Users can search and browse the knowledgebase by genes, variants, drugs, diseases, and pathways. Registration is free to the entire research community, but subject to agreement to use for research purposes only and not to redistribute. Registered users can access and download data to aid in the design of future pharmacogenetics and pharmacogenomics studies.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2013 PMID： 23824865 PMCID： PMC4084821 DOI： 10.1007/978-1-62703-435-7_20

Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745

33 in total

1. CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network.

Authors: M V Relling; T E Klein
Journal: Clin Pharmacol Ther Date: 2011-01-26 Impact factor: 6.875

2. Compilation of a comprehensive gene panel for systematic assessment of genes that govern an individual's drug responses.

Authors: Junjie Feng; Jielin Sun; Michael Zhuo Wang; Zheng Zhang; Seong-Tae Kim; Yi Zhu; Jishan Sun; Jianfeng Xu
Journal: Pharmacogenomics Date: 2010-10 Impact factor: 2.533

3. PharmGKB: understanding the effects of individual genetic variants.

Authors: Katrin Sangkuhl; Dorit S Berlin; Russ B Altman; Teri E Klein
Journal: Drug Metab Rev Date: 2008 Impact factor: 4.518

4. Pharmacogenomics and bioinformatics: PharmGKB.

Authors: Caroline F Thorn; Teri E Klein; Russ B Altman
Journal: Pharmacogenomics Date: 2010-04 Impact factor: 2.533

5. PharmGKB summary: methotrexate pathway.

Authors: Torben S Mikkelsen; Caroline F Thorn; Jun J Yang; Cornelia M Ulrich; Deborah French; Gianluigi Zaza; Henry M Dunnenberger; Sharon Marsh; Howard L McLeod; Kathy Giacomini; Mara L Becker; Roger Gaedigk; James Steven Leeder; Leo Kager; Mary V Relling; William Evans; Teri E Klein; Russ B Altman
Journal: Pharmacogenet Genomics Date: 2011-10 Impact factor: 2.089

Review 6. Vascular endothelial growth factor pathway.

Authors: Michael L Maitland; Xing Jian Lou; Jacqueline Ramirez; Apurva A Desai; Dorit S Berlin; Howard L McLeod; Ralph R Weichselbaum; Mark J Ratain; Russ B Altman; Teri E Klein
Journal: Pharmacogenet Genomics Date: 2010-05 Impact factor: 2.089

7. Etoposide pathway.

Authors: Jun Yang; Alessia Bogni; Erin G Schuetz; Mark Ratain; M Eileen Dolan; Howard McLeod; Li Gong; Caroline Thorn; Mary V Relling; Teri E Klein; Russ B Altman
Journal: Pharmacogenet Genomics Date: 2009-07 Impact factor: 2.089

8. A pharmacogene database enhanced by the 1000 Genomes Project.

Authors: Eric R Gamazon; Wei Zhang; R Stephanie Huang; M Eileen Dolan; Nancy J Cox
Journal: Pharmacogenet Genomics Date: 2009-10 Impact factor: 2.089

9. The BioPAX community standard for pathway data sharing.

Authors: Emek Demir; Michael P Cary; Suzanne Paley; Ken Fukuda; Christian Lemer; Imre Vastrik; Guanming Wu; Peter D'Eustachio; Carl Schaefer; Joanne Luciano; Frank Schacherer; Irma Martinez-Flores; Zhenjun Hu; Veronica Jimenez-Jacinto; Geeta Joshi-Tope; Kumaran Kandasamy; Alejandra C Lopez-Fuentes; Huaiyu Mi; Elgar Pichler; Igor Rodchenkov; Andrea Splendiani; Sasha Tkachev; Jeremy Zucker; Gopal Gopinath; Harsha Rajasimha; Ranjani Ramakrishnan; Imran Shah; Mustafa Syed; Nadia Anwar; Ozgün Babur; Michael Blinov; Erik Brauner; Dan Corwin; Sylva Donaldson; Frank Gibbons; Robert Goldberg; Peter Hornbeck; Augustin Luna; Peter Murray-Rust; Eric Neumann; Oliver Ruebenacker; Oliver Reubenacker; Matthias Samwald; Martijn van Iersel; Sarala Wimalaratne; Keith Allen; Burk Braun; Michelle Whirl-Carrillo; Kei-Hoi Cheung; Kam Dahlquist; Andrew Finney; Marc Gillespie; Elizabeth Glass; Li Gong; Robin Haw; Michael Honig; Olivier Hubaut; David Kane; Shiva Krupa; Martina Kutmon; Julie Leonard; Debbie Marks; David Merberg; Victoria Petri; Alex Pico; Dean Ravenscroft; Liya Ren; Nigam Shah; Margot Sunshine; Rebecca Tang; Ryan Whaley; Stan Letovksy; Kenneth H Buetow; Andrey Rzhetsky; Vincent Schachter; Bruno S Sobral; Ugur Dogrusoz; Shannon McWeeney; Mirit Aladjem; Ewan Birney; Julio Collado-Vides; Susumu Goto; Michael Hucka; Nicolas Le Novère; Natalia Maltsev; Akhilesh Pandey; Paul Thomas; Edgar Wingender; Peter D Karp; Chris Sander; Gary D Bader
Journal: Nat Biotechnol Date: 2010-09-09 Impact factor: 54.908

10. DrugBank: a comprehensive resource for in silico drug discovery and exploration.

Authors: David S Wishart; Craig Knox; An Chi Guo; Savita Shrivastava; Murtaza Hassanali; Paul Stothard; Zhan Chang; Jennifer Woolsey
Journal: Nucleic Acids Res Date: 2006-01-01 Impact factor: 16.971

94 in total

1. A Template for Authoring and Adapting Genomic Medicine Content in the eMERGE Infobutton Project.

Authors: Casey L Overby; Luke V Rasmussen; Andrea Hartzler; John J Connolly; Josh F Peterson; RoseMary E Hedberg; Robert R Freimuth; Brian H Shirts; Joshua C Denny; Eric B Larson; Christopher G Chute; Gail P Jarvik; James D Ralston; Alan R Shuldiner; Justin Starren; Iftikhar J Kullo; Peter Tarczy-Hornoch; Marc S Williams
Journal: AMIA Annu Symp Proc Date: 2014-11-14

2. IFN-γ enhances cell-mediated cytotoxicity against keratinocytes via JAK2/STAT1 in lichen planus.

Authors: Shuai Shao; Lam C Tsoi; Mrinal K Sarkar; Xianying Xing; Ke Xue; Ranjitha Uppala; Celine C Berthier; Chang Zeng; Matthew Patrick; Allison C Billi; Joseph Fullmer; Maria A Beamer; Bethany Perez-White; Spiro Getsios; Andrew Schuler; John J Voorhees; Sung Choi; Paul Harms; J Michelle Kahlenberg; Johann E Gudjonsson
Journal: Sci Transl Med Date: 2019-09-25 Impact factor: 17.956

3. Predicting Tumor Cell Response to Synergistic Drug Combinations Using a Novel Simplified Deep Learning Model.

Authors: Heming Zhang; Jiarui Feng; Amanda Zeng; Philip Payne; Fuhai Li
Journal: AMIA Annu Symp Proc Date: 2021-01-25

Review 4. Pharmacogenetics: can genes determine treatment efficacy and safety in JIA?

Authors: Heinrike Schmeling; Gerd Horneff; Susanne M Benseler; Marvin J Fritzler
Journal: Nat Rev Rheumatol Date: 2014-08-12 Impact factor: 20.543

Review 5. Precision Medicine Goes Microscopic: Engineering the Microbiome to Improve Drug Outcomes.

Authors: Kathy N Lam; Margaret Alexander; Peter J Turnbaugh
Journal: Cell Host Microbe Date: 2019-07-10 Impact factor: 21.023

6. Minimum information required for a DMET experiment reporting.

Authors: Judit Kumuthini; Mamana Mbiyavanga; Emile R Chimusa; Jyotishman Pathak; Panu Somervuo; Ron Hn Van Schaik; Vita Dolzan; Clint Mizzi; Kusha Kalideen; Raj S Ramesar; Milan Macek; George P Patrinos; Alessio Squassina
Journal: Pharmacogenomics Date: 2016-08-22 Impact factor: 2.533