Literature DB >> 23824863

The hydrodynamic tail vein assay as a tool for the study of liver promoters and enhancers.

Mee J Kim1, Nadav Ahituv.   

Abstract

The hydrodynamic tail vein injection is a technique that is used to deliver nucleic acids into live mice. Delivery through this method results in the in vivo transfection of foreign DNA primarily in the liver. Here, we describe the use of this technique to test for regulatory activity of liver promoters and enhancers, using a dual luciferase reporter system as the readable/measureable output and how this application can be used for pharmacogenomic studies.

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Year:  2013        PMID： 23824863      PMCID： PMC4096022          DOI： 10.1007/978-1-62703-435-7_18

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  19 in total

1.  High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA.

Authors:  G Zhang; V Budker; J A Wolff
Journal:  Hum Gene Ther       Date:  1999-07-01       Impact factor: 5.695

2.  Efficient delivery of siRNA for inhibition of gene expression in postnatal mice.

Authors:  David L Lewis; James E Hagstrom; Aaron G Loomis; Jon A Wolff; Hans Herweijer
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3.  Time course of gene expression after plasmid DNA gene transfer to the liver.

Authors:  H Herweijer; G Zhang; V M Subbotin; V Budker; P Williams; J A Wolff
Journal:  J Gene Med       Date:  2001 May-Jun       Impact factor: 4.565

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Authors:  H Herweijer; J A Wolff
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5.  Functional characterization of liver enhancers that regulate drug-associated transporters.

Authors:  M J Kim; P Skewes-Cox; H Fukushima; S Hesselson; S W Yee; L B Ramsey; L Nguyen; J L Eshragh; R A Castro; C C Wen; D Stryke; S J Johns; T E Ferrin; P-Y Kwok; M V Relling; K M Giacomini; D L Kroetz; N Ahituv
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Authors:  W S Simonet; N Bucay; S J Lauer; J M Taylor
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Authors:  Adrish Sen; Robert Steele; Asish K Ghosh; Arnab Basu; Ranjit Ray; Ratna B Ray
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  16 in total

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Authors:  Shipra Bhatia; Dirk A Kleinjan
Journal:  Hum Genet       Date:  2014-02-05       Impact factor: 4.132

2.  In Vivo Hepatic Enhancer Elements in the Human ABCG2 Locus.

Authors:  Rachel J Eclov; Mee J Kim; Robin P Smith; Xiaomin Liang; Nadav Ahituv; Deanna L Kroetz
Journal:  Drug Metab Dispos       Date:  2016-11-17       Impact factor: 3.922

Review 3.  Decoding enhancers using massively parallel reporter assays.

Authors:  Fumitaka Inoue; Nadav Ahituv
Journal:  Genomics       Date:  2015-06-10       Impact factor: 5.736

4.  ABCG2 regulatory single-nucleotide polymorphisms alter in vivo enhancer activity and expression.

Authors:  Rachel J Eclov; Mee J Kim; Aparna Chhibber; Robin P Smith; Nadav Ahituv; Deanna L Kroetz
Journal:  Pharmacogenet Genomics       Date:  2017-12       Impact factor: 2.089

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Review 6.  CRISPR somatic genome engineering and cancer modeling in the mouse pancreas and liver.

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7.  TALEN-mediated somatic mutagenesis in murine models of cancer.

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8.  Improved efficiency of genome editing by constitutive expression of Cas9 endonuclease in genetically-modified mice.

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9.  Tissue-specific activation of gene expression by the Synergistic Activation Mediator (SAM) CRISPRa system in mice.

Authors:  Charleen Hunt; Suzanne A Hartford; Derek White; Evangelos Pefanis; Timothy Hanna; Clarissa Herman; Jarrell Wiley; Heather Brown; Qi Su; Yurong Xin; Dennis Voronin; Hien Nguyen; Judith Altarejos; Keith Crosby; Jeffery Haines; Sarah Cancelarich; Meghan Drummond; Sven Moller-Tank; Ryan Malpass; Jacqueline Buckley; Maria Del Pilar Molina-Portela; Gustavo Droguett; David Frendewey; Eric Chiao; Brian Zambrowicz; Guochun Gong
Journal:  Nat Commun       Date:  2021-05-13       Impact factor: 14.919

10.  Systematic dissection of coding exons at single nucleotide resolution supports an additional role in cell-specific transcriptional regulation.

Authors:  Ramon Y Birnbaum; Rupali P Patwardhan; Mee J Kim; Gregory M Findlay; Beth Martin; Jingjing Zhao; Robert J A Bell; Robin P Smith; Angel A Ku; Jay Shendure; Nadav Ahituv
Journal:  PLoS Genet       Date:  2014-10-23       Impact factor: 5.917
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