Literature DB >> 12145662

Efficient delivery of siRNA for inhibition of gene expression in postnatal mice.

David L Lewis1, James E Hagstrom, Aaron G Loomis, Jon A Wolff, Hans Herweijer.   

Abstract

It has recently been shown that RNA interference can be induced in cultured mammalian cells by delivery of short interfering RNAs (siRNAs). Here we describe a method for efficient in vivo delivery of siRNAs to organs of postnatal mice and demonstrate effective and specific inhibition of transgene expression in a variety of organs.

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Year:  2002        PMID： 12145662     DOI： 10.1038/ng944

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  116 in total

1.  A simple and cost-effective method for producing small interfering RNAs with high efficacy.

Authors:  Muhammad Sohail; Graeme Doran; Johann Riedemann; Val Macaulay; Edwin M Southern
Journal:  Nucleic Acids Res       Date:  2003-04-01       Impact factor: 16.971

2.  Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference.

Authors:  Xian Chu Kong; Patrizia Barzaghi; Markus A Ruegg
Journal:  EMBO Rep       Date:  2004-01-16       Impact factor: 8.807

3.  Hydroporation as the mechanism of hydrodynamic delivery.

Authors:  G Zhang; X Gao; Y K Song; R Vollmer; D B Stolz; J Z Gasiorowski; D A Dean; D Liu
Journal:  Gene Ther       Date:  2004-04       Impact factor: 5.250

Review 4.  Tracking dendritic cells in vivo: insights into DC biology and function.

Authors:  Huiming Hon; Joshy Jacob
Journal:  Immunol Res       Date:  2004       Impact factor: 2.829

Review 5.  Pharmaceutical prospects for RNA interference.

Authors:  Raymond M Schiffelers; Martin C Woodle; Puthupparampil Scaria
Journal:  Pharm Res       Date:  2004-01       Impact factor: 4.200

6.  Combining competition assays with genetic complementation strategies to dissect mouse embryonic stem cell self-renewal and pluripotency.

Authors:  Dung-Fang Lee; Jie Su; Ana Sevilla; Julian Gingold; Christoph Schaniel; Ihor R Lemischka
Journal:  Nat Protoc       Date:  2012-03-22       Impact factor: 13.491

7.  Suppression of vascular endothelial growth factor via siRNA interference modulates the biological behavior of human nasopharyngeal carcinoma cells.

Authors:  Hai B Zhou; Yi F Yin; Yan Hu; Xin Li; Li Y Zou; Yong J Li; Yu Gu; Bao Q Ou; Juan Fu; Jun H Du; Gang Wu
Journal:  Jpn J Radiol       Date:  2011-09-29       Impact factor: 2.374

8.  Canonical transient receptor potential 3 channels activate NF-κB to mediate allergic airway disease via PKC-α/IκB-α and calcineurin/IκB-β pathways.

Authors:  Tengyao Song; Yun-Min Zheng; Peter A Vincent; Dongsheng Cai; Paul Rosenberg; Yong-Xiao Wang
Journal:  FASEB J       Date:  2015-09-15       Impact factor: 5.191

9.  Use of RNA interference to inhibit integrin (alpha6beta4)-mediated invasion and migration of breast carcinoma cells.

Authors:  Elizabeth A Lipscomb; Aisling S Dugan; Isaac Rabinovitz; Arthur M Mercurio
Journal:  Clin Exp Metastasis       Date:  2003       Impact factor: 5.150

Review 10.  Therapeutic gene silencing in neurological disorders, using interfering RNA.

Authors:  G Scott Ralph; Nicholas D Mazarakis; Mimoun Azzouz
Journal:  J Mol Med (Berl)       Date:  2005-03-10       Impact factor: 4.599
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