Seung Hyun Lee1, Jin Hur, Young Jin Kim, Hye-Jeong Lee, Yoo Jin Hong, Byoung Wook Choi. 1. Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, 120-752 Seoul, Republic of Korea. Electronic address: circle1128@yuhs.ac.
Abstract
OBJECTIVES: To investigate the feasibility of dual-energy computed tomography (DECT) in differentiating malignant from benign mediastinal tumors. MATERIALS AND METHODS: We prospectively enrolled 25 patients (14 males; mean age: 56.7 years) who had suspected mediastinal tumors on chest radiography or non-contrast chest computed tomography (CT). All patients underwent a two-phase DECT using gemstone spectral imaging (GSI) mode (GE HD750). For the quantitative analysis, two investigators measured the following parameters of the tumors in the early and the delayed phases: CT attenuation value in Hounsfield units (HU) and iodine concentration (mg/ml). Pathological results were used for a final diagnosis. Statistical analyses were performed using the Fisher's exact test and the Mann-Whitney t-test. RESULTS: 10 patients (40%) had benign pathology, while 15 (60%) had malignant pathology. The iodine concentration measurements were significantly different between benign and malignant tumors both in the early phase (1.38 mg/ml vs. 2.41 mg/ml, p=0.001) and in the delayed phase (1.52 mg/ml vs. 2.84 mg/ml, p=0.001), while mean attenuation values were not significantly different in both phases (57.8 HU vs. 69.1 HU, p=0.067 and 67.4 HU vs. 78.4 HU, p=0.086, respectively). CONCLUSIONS: Dual-energy CT using a quantitative analytic methodology can be used to differentiate between benign and malignant mediastinal tumors.
OBJECTIVES: To investigate the feasibility of dual-energy computed tomography (DECT) in differentiating malignant from benign mediastinal tumors. MATERIALS AND METHODS: We prospectively enrolled 25 patients (14 males; mean age: 56.7 years) who had suspected mediastinal tumors on chest radiography or non-contrast chest computed tomography (CT). All patients underwent a two-phase DECT using gemstone spectral imaging (GSI) mode (GE HD750). For the quantitative analysis, two investigators measured the following parameters of the tumors in the early and the delayed phases: CT attenuation value in Hounsfield units (HU) and iodine concentration (mg/ml). Pathological results were used for a final diagnosis. Statistical analyses were performed using the Fisher's exact test and the Mann-Whitney t-test. RESULTS: 10 patients (40%) had benign pathology, while 15 (60%) had malignant pathology. The iodine concentration measurements were significantly different between benign and malignant tumors both in the early phase (1.38 mg/ml vs. 2.41 mg/ml, p=0.001) and in the delayed phase (1.52 mg/ml vs. 2.84 mg/ml, p=0.001), while mean attenuation values were not significantly different in both phases (57.8 HU vs. 69.1 HU, p=0.067 and 67.4 HU vs. 78.4 HU, p=0.086, respectively). CONCLUSIONS: Dual-energy CT using a quantitative analytic methodology can be used to differentiate between benign and malignant mediastinal tumors.
Authors: Giuseppe Cicero; Giorgio Ascenti; Moritz H Albrecht; Alfredo Blandino; Marco Cavallaro; Tommaso D'Angelo; Maria Ludovica Carerj; Thomas J Vogl; Silvio Mazziotti Journal: Radiol Med Date: 2020-01-10 Impact factor: 3.469
Authors: Suyon Chang; Jin Hur; Dong Jin Im; Young Joo Suh; Yoo Jin Hong; Hye-Jeong Lee; Young Jin Kim; Kyunghwa Han; Dae Joon Kim; Chang Young Lee; Ha Young Shin; Byoung Wook Choi Journal: Eur Radiol Date: 2016-08-23 Impact factor: 5.315
Authors: S T Laroia; Ajeet Singh Bhadoria; Yamini Venigalla; G K Chibber; Chagan Bihari; Archana Rastogi; S K Sarin Journal: Eur J Radiol Open Date: 2016-07-20