Wei Nie1, Cheng Xue, Jiquan Chen, Qingyu Xiu. 1. Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China. niewei-1001@163.com
Abstract
BACKGROUND: Epidemiological studies have evaluated the association between Secretoglobin 1A member 1 (SCGB1A1) +38A/G polymorphism and asthma, but the results remain inconclusive. The aim of this study was to perform a meta-analysis to investigate a more authentic association between SCGB1A1 +38A/G polymorphism and asthma. METHODS: Published literature from PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Embase databases were searched for eligible publications. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random or fixed-effect model according the between-study heterogeneity. RESULTS: A total of 19 case-control studies in 18 articles were included in the meta-analysis, including 3191 cases and 5182 controls. We found that SCGB1A1 +38A/G polymorphism was associated with a significantly increased risk of asthma risk when all studies were pooled in a dominant model (OR=1.29; 95% CI 1.08-1.54; P=0.005). The cumulative meta-analysis and sensitivity analysis further strengthened the stability of the result. Furthermore, publication bias was not detected. CONCLUSIONS: This study suggested that SCGB1A1 +38A/G polymorphism was a risk factor for asthma. Further large and well-designed studies are needed to confirm this association.
BACKGROUND: Epidemiological studies have evaluated the association between Secretoglobin 1A member 1 (SCGB1A1) +38A/G polymorphism and asthma, but the results remain inconclusive. The aim of this study was to perform a meta-analysis to investigate a more authentic association between SCGB1A1+38A/G polymorphism and asthma. METHODS: Published literature from PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Embase databases were searched for eligible publications. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random or fixed-effect model according the between-study heterogeneity. RESULTS: A total of 19 case-control studies in 18 articles were included in the meta-analysis, including 3191 cases and 5182 controls. We found that SCGB1A1+38A/G polymorphism was associated with a significantly increased risk of asthma risk when all studies were pooled in a dominant model (OR=1.29; 95% CI 1.08-1.54; P=0.005). The cumulative meta-analysis and sensitivity analysis further strengthened the stability of the result. Furthermore, publication bias was not detected. CONCLUSIONS: This study suggested that SCGB1A1+38A/G polymorphism was a risk factor for asthma. Further large and well-designed studies are needed to confirm this association.
Authors: Christian Rosas-Salazar; Tebeb Gebretsadik; Kecia N Carroll; Sara Reiss; Nancy Wickersham; Emma K Larkin; Kristina M James; E Kathryn Miller; Larry J Anderson; Tina V Hartert Journal: Pediatr Allergy Immunol Pulmonol Date: 2015-09-01 Impact factor: 1.349
Authors: Olivier Côté; Mary Ellen Clark; Laurent Viel; Geneviève Labbé; Stephen Y K Seah; Meraj A Khan; David N Douda; Nades Palaniyar; Dorothee Bienzle Journal: PLoS One Date: 2014-04-28 Impact factor: 3.240