| Literature DB >> 23817570 |
Yongyong Shi1, Li Li, Zhibin Hu, Shuang Li, Shixuan Wang, Jihong Liu, Chen Wu, Lin He, Jianfeng Zhou, Zhiqiang Li, Ting Hu, Yile Chen, Yao Jia, Shaoshuai Wang, Li Wu, Xiaodong Cheng, Zhijun Yang, Ru Yang, Xiong Li, Kecheng Huang, Qinghua Zhang, Hang Zhou, Fangxu Tang, Zhilan Chen, Jian Shen, Jie Jiang, Hu Ding, Hui Xing, Shulan Zhang, Pengpeng Qu, Xiaojie Song, Zhongqiu Lin, Dongrui Deng, Ling Xi, Weiguo Lv, Xiaobing Han, Guangshi Tao, Lixing Yan, Zhedong Han, Zhuang Li, Xiaoping Miao, Shandong Pan, Yuanming Shen, Hui Wang, Dan Liu, Ee Gong, Zheng Li, Limei Zhou, Xiaomei Luan, Chuping Wang, Qian Song, Sufang Wu, Hongbin Xu, Jiawei Shen, Fulin Qiang, Gang Ma, Li Liu, Xiaojun Chen, Jibin Liu, Jiangping Wu, Yan Shen, Yang Wen, Minjie Chu, Jiang Yu, Xiaoxia Hu, Yujuan Fan, Hongying He, Yanming Jiang, Zhiying Lei, Cui Liu, Jianhua Chen, Yuan Zhang, Cunjian Yi, Shuangyun Chen, Wenjin Li, Daowen Wang, Zehua Wang, Wen Di, Keng Shen, Dongxin Lin, Hongbing Shen, Youji Feng, Xing Xie, Ding Ma.
Abstract
To identify new genetic risk factors for cervical cancer, we conducted a genome-wide association study in the Han Chinese population. The initial discovery set included 1,364 individuals with cervical cancer (cases) and 3,028 female controls, and we selected a 'stringently matched samples' subset (829 cases and 990 controls) from the discovery set on the basis of principal component analysis; the follow-up stages included two independent sample sets (1,824 cases and 3,808 controls for follow-up 1 and 2,343 cases and 3,388 controls for follow-up 2). We identified strong evidence of associations between cervical cancer and two new loci: 4q12 (rs13117307, Pcombined, stringently matched=9.69×10(-9), per-allele odds ratio (OR)stringently matched=1.26) and 17q12 (rs8067378, Pcombined, stringently matched=2.00×10(-8), per-allele ORstringently matched=1.18). We additionally replicated an association between HLA-DPB1 and HLA-DPB2 (HLA-DPB1/2) at 6p21.32 and cervical cancer (rs4282438, Pcombined, stringently matched=4.52×10(-27), per-allele ORstringently matched=0.75). Our findings provide new insights into the genetic etiology of cervical cancer.Entities:
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Year: 2013 PMID： 23817570 DOI： 10.1038/ng.2687
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330