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Literature DB >> 23817310

Adult-specific functions of animal microRNAs.

Abstract

MicroRNAs (miRNAs) are ~22 nt RNAs that coordinate vast regulatory networks in animals and thereby influence myriad processes. This Review examines evidence that miRNAs have continuous roles in adults in ways that are separable from developmental control. Adult-specific activities for miRNAs have been described in various stem cell populations, in the context of neural function and cardiovascular biology, in metabolism and ageing, and during cancer. In addition to reviewing recent results, we also discuss methods for studying miRNA activities specifically in adults and evaluate their relative strengths and weaknesses. A fuller understanding of continuous functions of miRNAs in adults has bearing on efforts and opportunities to manipulate miRNAs for therapeutic purposes.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
MicroRNAs

Year: 2013 PMID： 23817310 PMCID： PMC4136762 DOI： 10.1038/nrg3471

Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242

192 in total

1. Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus.

Authors: Tigwa H Davis; Trinna L Cuellar; Selina M Koch; Allison J Barker; Brian D Harfe; Michael T McManus; Erik M Ullian
Journal: J Neurosci Date: 2008-04-23 Impact factor: 6.167

2. LNA-mediated microRNA silencing in non-human primates.

Authors: Joacim Elmén; Morten Lindow; Sylvia Schütz; Matthew Lawrence; Andreas Petri; Susanna Obad; Marie Lindholm; Maj Hedtjärn; Henrik Frydenlund Hansen; Urs Berger; Steven Gullans; Phil Kearney; Peter Sarnow; Ellen Marie Straarup; Sakari Kauppinen
Journal: Nature Date: 2008-03-26 Impact factor: 49.962

3. Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling.

Authors: Paula A da Costa Martins; Meriem Bourajjaj; Monika Gladka; Mara Kortland; Ralph J van Oort; Yigal M Pinto; Jeffery D Molkentin; Leon J De Windt
Journal: Circulation Date: 2008-09-22 Impact factor: 29.690

4. Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol.

Authors: Andrzej Z Pietrzykowski; Ryan M Friesen; Gilles E Martin; Sylvie I Puig; Cheryl L Nowak; Patricia M Wynne; Hava T Siegelmann; Steven N Treistman
Journal: Neuron Date: 2008-07-31 Impact factor: 17.173

5. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2.

Authors: Sun-Mi Park; Arti B Gaur; Ernst Lengyel; Marcus E Peter
Journal: Genes Dev Date: 2008-04-01 Impact factor: 11.361

6. The let-7 microRNA reduces tumor growth in mouse models of lung cancer.

Authors: Aurora Esquela-Kerscher; Phong Trang; Jason F Wiggins; Lubna Patrawala; Angie Cheng; Lance Ford; Joanne B Weidhaas; David Brown; Andreas G Bader; Frank J Slack
Journal: Cell Cycle Date: 2008-03-03 Impact factor: 4.534

7. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.

Authors: Philip A Gregory; Andrew G Bert; Emily L Paterson; Simon C Barry; Anna Tsykin; Gelareh Farshid; Mathew A Vadas; Yeesim Khew-Goodall; Gregory J Goodall
Journal: Nat Cell Biol Date: 2008-03-30 Impact factor: 28.824

Review 8. Lessons from microRNA mutants in worms, flies and mice.

Authors: Peter Smibert; Eric C Lai
Journal: Cell Cycle Date: 2008-08-17 Impact factor: 4.534

9. MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors.

Authors: Jun Lu; Shangqin Guo; Benjamin L Ebert; Hao Zhang; Xiao Peng; Jocelyn Bosco; Jennifer Pretz; Rita Schlanger; Judy Y Wang; Raymond H Mak; David M Dombkowski; Frederic I Preffer; David T Scadden; Todd R Golub
Journal: Dev Cell Date: 2008-06 Impact factor: 12.270

10. Most Caenorhabditis elegans microRNAs are individually not essential for development or viability.

Authors: Eric A Miska; Ezequiel Alvarez-Saavedra; Allison L Abbott; Nelson C Lau; Andrew B Hellman; Shannon M McGonagle; David P Bartel; Victor R Ambros; H Robert Horvitz
Journal: PLoS Genet Date: 2007-12 Impact factor: 5.917

163 in total

Review 1. MicroRNA-Based Therapeutic Strategies for Targeting Mutant and Wild Type RAS in Cancer.

Authors: Sriganesh B Sharma; John Michael Ruppert
Journal: Drug Dev Res Date: 2015-08-18 Impact factor: 4.360

2. Identification a novel tumor-suppressive hsa-miR-599 regulates cells proliferation, migration and invasion by targeting oncogenic MYC in hepatocellular carcinoma.

Authors: Jingjing Tian; Xibao Hu; Wei Gao; Jie Zhang; Ming Chen; Xinrong Zhang; Junhong Ma; Hongxia Yuan
Journal: Am J Transl Res Date: 2016-06-15 Impact factor: 4.060

Adult-specific functions of animal microRNAs.

1. Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus.

2. LNA-mediated microRNA silencing in non-human primates.

3. Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling.

4. Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol.

5. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2.

6. The let-7 microRNA reduces tumor growth in mouse models of lung cancer.

7. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.

Review 8. Lessons from microRNA mutants in worms, flies and mice.

9. MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors.

10. Most Caenorhabditis elegans microRNAs are individually not essential for development or viability.

Review 1. MicroRNA-Based Therapeutic Strategies for Targeting Mutant and Wild Type RAS in Cancer.

2. Identification a novel tumor-suppressive hsa-miR-599 regulates cells proliferation, migration and invasion by targeting oncogenic MYC in hepatocellular carcinoma.

Review 3. Hox miRNA regulation within the Drosophila Bithorax complex: Patterning behavior.

4. CircRNA TGFBR2/MiR-25-3p/TWIST1 axis regulates osteoblast differentiation of human aortic valve interstitial cells.

5. MicroRNA-128 promotes proliferation in osteosarcoma cells by downregulating PTEN.

6. Expression of miRNA-630 in bladder urothelial carcinoma and its clinical significance.

7. The mir-279/996 cluster represses receptor tyrosine kinase signaling to determine cell fates in the Drosophila eye.

8. MiR-145 inhibits osteosarcoma cells proliferation and invasion by targeting ROCK1.

9. MicroRNA-148b expression is decreased in hepatocellular carcinoma and associated with prognosis.

10. MicroRNA-92 promotes gastric cancer cell proliferation and invasion through targeting FXR.