Literature DB >> 23817236

Sequential addition of reprogramming factors improves efficiency.

X Gaeta, Y Xie, W E Lowry.   

Abstract

Addition of a specific set of transcription factors reprograms somatic cell nuclei to a pluripotent state. Sequential addition of these factors, rather than the simultaneous exposure used in standard protocols, improves reprogramming efficiency. This sequential method favours a transition through a state with enhanced mesenchymal characteristics before driving an epithelial transformation on the way to the pluripotent state.

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Year:  2013        PMID： 23817236      PMCID： PMC5842428          DOI： 10.1038/ncb2800

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  20 in total

1.  A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts.

Authors:  Ronghui Li; Jialiang Liang; Su Ni; Ting Zhou; Xiaobing Qing; Huapeng Li; Wenzhi He; Jiekai Chen; Feng Li; Qiang Zhuang; Baoming Qin; Jianyong Xu; Wen Li; Jiayin Yang; Yi Gan; Dajiang Qin; Shipeng Feng; Hong Song; Dongshan Yang; Biliang Zhang; Lingwen Zeng; Liangxue Lai; Miguel Angel Esteban; Duanqing Pei
Journal:  Cell Stem Cell       Date:  2010-06-17       Impact factor: 24.633

2.  Elite and stochastic models for induced pluripotent stem cell generation.

Authors:  Shinya Yamanaka
Journal:  Nature       Date:  2009-07-02       Impact factor: 49.962

3.  A late transition in somatic cell reprogramming requires regulators distinct from the pluripotency network.

Authors:  Azadeh Golipour; Laurent David; Yu Liu; Gowtham Jayakumaran; Calley L Hirsch; Dan Trcka; Jeffrey L Wrana
Journal:  Cell Stem Cell       Date:  2012-12-07       Impact factor: 24.633

4.  Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells.

Authors:  Sergio Ruiz; Dinh Diep; Athurva Gore; Athanasia D Panopoulos; Nuria Montserrat; Nongluk Plongthongkum; Sachin Kumar; Ho-Lim Fung; Alessandra Giorgetti; Josipa Bilic; Erika M Batchelder; Holm Zaehres; Natalia G Kan; Hans Robert Schöler; Mark Mercola; Kun Zhang; Juan Carlos Izpisua Belmonte
Journal:  Proc Natl Acad Sci U S A       Date:  2012-09-18       Impact factor: 11.205

5.  Facilitators and impediments of the pluripotency reprogramming factors' initial engagement with the genome.

Authors:  Abdenour Soufi; Greg Donahue; Kenneth S Zaret
Journal:  Cell       Date:  2012-11-15       Impact factor: 41.582

6.  Induction of pluripotent stem cells from adult human fibroblasts by defined factors.

Authors:  Kazutoshi Takahashi; Koji Tanabe; Mari Ohnuki; Megumi Narita; Tomoko Ichisaka; Kiichiro Tomoda; Shinya Yamanaka
Journal:  Cell       Date:  2007-11-30       Impact factor: 41.582

7.  Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase.

Authors:  Yosef Buganim; Dina A Faddah; Albert W Cheng; Elena Itskovich; Styliani Markoulaki; Kibibi Ganz; Sandy L Klemm; Alexander van Oudenaarden; Rudolf Jaenisch
Journal:  Cell       Date:  2012-09-14       Impact factor: 41.582

8.  A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.

Authors:  Justin K Ichida; Joel Blanchard; Kelvin Lam; Esther Y Son; Julia E Chung; Dieter Egli; Kyle M Loh; Ava C Carter; Francesco P Di Giorgio; Kathryn Koszka; Danwei Huangfu; Hidenori Akutsu; David R Liu; Lee L Rubin; Kevin Eggan
Journal:  Cell Stem Cell       Date:  2009-10-08       Impact factor: 24.633

9.  A molecular roadmap of reprogramming somatic cells into iPS cells.

Authors:  Jose M Polo; Endre Anderssen; Ryan M Walsh; Benjamin A Schwarz; Christian M Nefzger; Sue Mei Lim; Marti Borkent; Effie Apostolou; Sara Alaei; Jennifer Cloutier; Ori Bar-Nur; Sihem Cheloufi; Matthias Stadtfeld; Maria Eugenia Figueroa; Daisy Robinton; Sridaran Natesan; Ari Melnick; Jinfang Zhu; Sridhar Ramaswamy; Konrad Hochedlinger
Journal:  Cell       Date:  2012-12-21       Impact factor: 41.582

10.  Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency.

Authors:  Tao Wang; Hao Wu; Yujing Li; Keith E Szulwach; Li Lin; Xuekun Li; I-Ping Chen; Ian S Goldlust; Stormy J Chamberlain; Ann Dodd; He Gong; Gene Ananiev; Ji Woong Han; Young-sup Yoon; M Katharine Rudd; Miao Yu; Chun-Xiao Song; Chuan He; Qiang Chang; Stephen T Warren; Peng Jin
Journal:  Nat Cell Biol       Date:  2013-05-19       Impact factor: 28.824
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  5 in total

Review 1.  Application of biomaterials to advance induced pluripotent stem cell research and therapy.

Authors:  Zhixiang Tong; Aniruddh Solanki; Allison Hamilos; Oren Levy; Kendall Wen; Xiaolei Yin; Jeffrey M Karp
Journal:  EMBO J       Date:  2015-03-12       Impact factor: 11.598

2.  Temporal Modulation of Stem Cell Activity Using Magnetoactive Hydrogels.

Authors:  Amr A Abdeen; Junmin Lee; N Ashwin Bharadwaj; Randy H Ewoldt; Kristopher A Kilian
Journal:  Adv Healthc Mater       Date:  2016-06-08       Impact factor: 9.933

3.  Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells.

Authors:  Yu Zhang; Michelle Zoltan; Erick Riquelme; Hanwen Xu; Ismet Sahin; Susana Castro-Pando; Maria Fernanda Montiel; Kyle Chang; Zhengyu Jiang; Jianhua Ling; Sonal Gupta; William Horne; Melissa Pruski; Huamin Wang; Shao-Cong Sun; Guillermina Lozano; Paul Chiao; Anirban Maitra; Steven D Leach; Jay K Kolls; Eduardo Vilar; Timothy C Wang; Jennifer M Bailey; Florencia McAllister
Journal:  Gastroenterology       Date:  2018-03-29       Impact factor: 22.682

Review 4.  Krüppel-like factors in cancer progression: three fingers on the steering wheel.

Authors:  Ridha Limame; Ken Op de Beeck; Filip Lardon; Olivier De Wever; Patrick Pauwels
Journal:  Oncotarget       Date:  2014-01-15

Review 5.  Epithelial-Mesenchymal Transition in Pancreatic Cancer: A Review.

Authors:  Shuai Wang; Shuai Huang; Yu Ling Sun
Journal:  Biomed Res Int       Date:  2017-12-12       Impact factor: 3.411
  5 in total

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