BACKGROUND: Crohn's disease (CD) is frequently associated with weight loss and malnutrition. However, as the prevalence of obesity increases worldwide, it may become a clinical problem even in CD. AIM: To assess the prevalence of severe/morbid obesity in CD patients and to compare their disease characteristics to nonobese CD patients. METHODS: A retrospective analysis of a computerized CD patient database was performed to identify severely/morbidly obese patients (BMI >35). Prevalence was compared to data of the general population. Severely/morbidly obese CD patients were then compared to randomly selected nonobese CD patients (BMI <30) in a 1:3 ratio. RESULTS: Thirteen severely/morbidly obese patients out of 560 CD patients were found (2.3%), which is significantly lower than the prevalence in the general population (5.6%, p = 0.001). When compared to 39 nonobese CD patients, colonic disease was significantly more common among severely/morbidly obese CD patients (odds ratio: 6, 95% CI: 1.35-26.3, p = 0.02), while there was no difference in other disease parameters. Interestingly, 4 morbidly obese CD patients had undergone laparoscopic sleeve gastrectomy for treatment of morbid obesity with a favorable surgical course. CONCLUSION: CD in severely/morbidly obese patients is more often colonic, but otherwise no different than CD in nonobese patients. Sleeve gastrectomy is a viable therapeutic option for morbidly obese CD patients.
BACKGROUND:Crohn's disease (CD) is frequently associated with weight loss and malnutrition. However, as the prevalence of obesity increases worldwide, it may become a clinical problem even in CD. AIM: To assess the prevalence of severe/morbid obesity in CDpatients and to compare their disease characteristics to nonobese CD patients. METHODS: A retrospective analysis of a computerized CDpatient database was performed to identify severely/morbidly obesepatients (BMI >35). Prevalence was compared to data of the general population. Severely/morbidly obese CDpatients were then compared to randomly selected nonobese CD patients (BMI <30) in a 1:3 ratio. RESULTS: Thirteen severely/morbidly obesepatients out of 560 CDpatients were found (2.3%), which is significantly lower than the prevalence in the general population (5.6%, p = 0.001). When compared to 39 nonobese CD patients, colonic disease was significantly more common among severely/morbidly obese CDpatients (odds ratio: 6, 95% CI: 1.35-26.3, p = 0.02), while there was no difference in other disease parameters. Interestingly, 4 morbidly obese CDpatients had undergone laparoscopic sleeve gastrectomy for treatment of morbid obesity with a favorable surgical course. CONCLUSION:CD in severely/morbidly obesepatients is more often colonic, but otherwise no different than CD in nonobese patients. Sleeve gastrectomy is a viable therapeutic option for morbidly obese CDpatients.
Authors: Manuel B Braga Neto; Martin H Gregory; Guilherme P Ramos; Fateh Bazerbachi; David H Bruining; Barham K Abu Dayyeh; Vladimir M Kushnir; Laura E Raffals; Matthew A Ciorba; Edward V Loftus; Parakkal Deepak Journal: Inflamm Bowel Dis Date: 2020-06-18 Impact factor: 5.325
Authors: Fateh Bazerbachi; Tarek Sawas; Eric J Vargas; Samir Haffar; Parakkal Deepak; John B Kisiel; Edward V Loftus; Barham K Abu Dayyeh Journal: Obes Surg Date: 2018-04 Impact factor: 4.129
Authors: Yves M Borbély; Alice Osterwalder; Dino Kröll; Philipp C Nett; Roman A Inglin Journal: World J Gastroenterol Date: 2017-07-14 Impact factor: 5.742