BACKGROUND AND PURPOSE: Multiple studies have demonstrated evidence of sex differences in patients with MS, including differences in disease progression, cognitive decline, and biologic markers. This study used functional connectivity MRI to investigate sex differences in the strength of functional connectivity of the default mode network in patients with MS and healthy control subjects. MATERIALS AND METHODS: A total of 16 men and 16 women with MS and 32 age- and sex-matched healthy control subjects underwent a whole-brain resting-state functional connectivity MRI scan. A group-based seed in the posterior cingulate was used to create whole-brain correlation maps. A 2 × 2 ANOVA was used to assess whether disease status and sex affected the strength of connectivity to the posterior cingulate. RESULTS: Patients with MS showed significantly stronger connectivity from the posterior cingulate to the bilateral medial frontal gyri, the left ventral anterior cingulate, the right putamen, and the left middle temporal gyrus (P < .0005). In the left dorsal lateral prefrontal cortex, female patients showed significantly stronger connectivity to the posterior cingulate cortex compared with female control subjects (P = 3 × 10(4)), and male control subjects showed stronger posterior cingulate cortex-left dorsal lateral prefrontal cortex connectivity in comparison to female control subjects (P = .002). Male patients showed significantly weaker connectivity to the caudate compared with female patients (P = .004). CONCLUSIONS: Disease status and sex interact to produce differences in the strength of functional connectivity from the posterior cingulate to the caudate and the left dorsal lateral prefrontal cortex.
BACKGROUND AND PURPOSE: Multiple studies have demonstrated evidence of sex differences in patients with MS, including differences in disease progression, cognitive decline, and biologic markers. This study used functional connectivity MRI to investigate sex differences in the strength of functional connectivity of the default mode network in patients with MS and healthy control subjects. MATERIALS AND METHODS: A total of 16 men and 16 women with MS and 32 age- and sex-matched healthy control subjects underwent a whole-brain resting-state functional connectivity MRI scan. A group-based seed in the posterior cingulate was used to create whole-brain correlation maps. A 2 × 2 ANOVA was used to assess whether disease status and sex affected the strength of connectivity to the posterior cingulate. RESULTS:Patients with MS showed significantly stronger connectivity from the posterior cingulate to the bilateral medial frontal gyri, the left ventral anterior cingulate, the right putamen, and the left middle temporal gyrus (P < .0005). In the left dorsal lateral prefrontal cortex, female patients showed significantly stronger connectivity to the posterior cingulate cortex compared with female control subjects (P = 3 × 10(4)), and male control subjects showed stronger posterior cingulate cortex-left dorsal lateral prefrontal cortex connectivity in comparison to female control subjects (P = .002). Male patients showed significantly weaker connectivity to the caudate compared with female patients (P = .004). CONCLUSIONS: Disease status and sex interact to produce differences in the strength of functional connectivity from the posterior cingulate to the caudate and the left dorsal lateral prefrontal cortex.
Authors: Bruce Fischl; David H Salat; Evelina Busa; Marilyn Albert; Megan Dieterich; Christian Haselgrove; Andre van der Kouwe; Ron Killiany; David Kennedy; Shuna Klaveness; Albert Montillo; Nikos Makris; Bruce Rosen; Anders M Dale Journal: Neuron Date: 2002-01-31 Impact factor: 17.173
Authors: David J Hawellek; Joerg F Hipp; Christopher M Lewis; Maurizio Corbetta; Andreas K Engel Journal: Proc Natl Acad Sci U S A Date: 2011-11-07 Impact factor: 11.205
Authors: Menno M Schoonheim; Jeroen J G Geurts; Doriana Landi; Linda Douw; Marieke L van der Meer; Hugo Vrenken; Chris H Polman; Frederik Barkhof; Cornelis J Stam Journal: Hum Brain Mapp Date: 2011-09-23 Impact factor: 5.038
Authors: Ziad S Saad; Daniel R Glen; Gang Chen; Michael S Beauchamp; Rutvik Desai; Robert W Cox Journal: Neuroimage Date: 2008-10-11 Impact factor: 6.556
Authors: Ugo Nocentini; Marco Bozzali; Barbara Spanò; Mara Cercignani; Laura Serra; Barbara Basile; Rosalba Mannu; Carlo Caltagirone; John De Luca Journal: Brain Imaging Behav Date: 2014-09 Impact factor: 3.978
Authors: R Antulov; B Weinstock-Guttman; J L Cox; S Hussein; J Durfee; C Caiola; M G Dwyer; N Bergsland; N Abdelrahman; M Stosic; D Hojnacki; F E Munschauer; D Miletic; R Zivadinov Journal: Mult Scler Date: 2008-11-21 Impact factor: 6.312
Authors: Judith M Segall; Elena A Allen; Rex E Jung; Erik B Erhardt; Sunil K Arja; Kent Kiehl; Vince D Calhoun Journal: Front Neuroinform Date: 2012-03-27 Impact factor: 4.081
Authors: Jed A Diekfuss; Dustin R Grooms; Katharine S Nissen; Daniel K Schneider; Kim D Barber Foss; Staci Thomas; Scott Bonnette; Jonathan A Dudley; Weihong Yuan; Danielle L Reddington; Jonathan D Ellis; James Leach; Michael Gordon; Craig Lindsey; Ken Rushford; Carlee Shafer; Gregory D Myer Journal: Braz J Phys Ther Date: 2019-07-17 Impact factor: 3.377
Authors: Marlene Tahedl; Seth M Levine; Mark W Greenlee; Robert Weissert; Jens V Schwarzbach Journal: Front Neurol Date: 2018-10-11 Impact factor: 4.003