N Ghouri1, D Purves, A McConnachie, J Wilson, J M R Gill, N Sattar. 1. BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK. nazim.ghouri@glasgow.ac.uk
Abstract
AIMS/HYPOTHESIS: This study aimed to determine the extent to which increased insulin resistance and fasting glycaemia in South Asian men, compared with white European men, living in the UK, was due to lower cardiorespiratory fitness (maximal oxygen uptake [VO(2max)]) and physical activity. METHODS: One hundred South Asian and 100 age- and BMI-matched European men without diagnosed diabetes, aged 40-70 years, had fasted blood taken for measurement of glucose concentration, HOMA-estimated insulin resistance (HOMA(IR)), plus other risk factors, and underwent assessment of physical activity (using accelerometry), VO(2max), body size and composition, and demographic and other lifestyle factors. For 13 South Asian and one European man, HbA1c levels were >6.5% (>48 mmol/mol), indicating potential undiagnosed diabetes; these men were excluded from the analyses. Linear regression models were used to determine the extent to which body size and composition, fitness and physical activity variables explained differences in HOMA(IR) and fasting glucose between South Asian and European men. RESULTS: HOMA(IR) and fasting glucose were 67% (p < 0.001) and 3% (p < 0.018) higher, respectively, in South Asians than Europeans. Lower VO(2max), lower physical activity and greater total adiposity in South Asians individually explained 68% (95% CI 45%, 91%), 29% (11%, 46%) and 52% (30%, 80%), respectively, and together explained 83% (50%, 119%) (all p < 0.001) of the ethnic difference in HOMA(IR). Lower VO(2max) and greater total adiposity, respectively, explained 61% (9%, 111%) and 39% (9%, 76%) (combined effect 63% [8%, 115%]; all p < 0.05) of the ethnic difference in fasting glucose. CONCLUSIONS/ INTERPRETATION: Lower cardiorespiratory fitness is a key factor associated with the excess insulin resistance and fasting glycaemia in middle-aged South Asian, compared with European, men living in the UK.
AIMS/HYPOTHESIS: This study aimed to determine the extent to which increased insulin resistance and fasting glycaemia in South Asian men, compared with white European men, living in the UK, was due to lower cardiorespiratory fitness (maximal oxygen uptake [VO(2max)]) and physical activity. METHODS: One hundred South Asian and 100 age- and BMI-matched European men without diagnosed diabetes, aged 40-70 years, had fasted blood taken for measurement of glucose concentration, HOMA-estimated insulin resistance (HOMA(IR)), plus other risk factors, and underwent assessment of physical activity (using accelerometry), VO(2max), body size and composition, and demographic and other lifestyle factors. For 13 South Asian and one European man, HbA1c levels were >6.5% (>48 mmol/mol), indicating potential undiagnosed diabetes; these men were excluded from the analyses. Linear regression models were used to determine the extent to which body size and composition, fitness and physical activity variables explained differences in HOMA(IR) and fasting glucose between South Asian and European men. RESULTS: HOMA(IR) and fasting glucose were 67% (p < 0.001) and 3% (p < 0.018) higher, respectively, in South Asians than Europeans. Lower VO(2max), lower physical activity and greater total adiposity in South Asians individually explained 68% (95% CI 45%, 91%), 29% (11%, 46%) and 52% (30%, 80%), respectively, and together explained 83% (50%, 119%) (all p < 0.001) of the ethnic difference in HOMA(IR). Lower VO(2max) and greater total adiposity, respectively, explained 61% (9%, 111%) and 39% (9%, 76%) (combined effect 63% [8%, 115%]; all p < 0.05) of the ethnic difference in fasting glucose. CONCLUSIONS/ INTERPRETATION: Lower cardiorespiratory fitness is a key factor associated with the excess insulin resistance and fasting glycaemia in middle-aged South Asian, compared with European, men living in the UK.
Authors: Emily D Williams; Emmanuel Stamatakis; Tarani Chandola; Mark Hamer Journal: J Epidemiol Community Health Date: 2010-06-04 Impact factor: 3.710
Authors: Fahad Razak; Sonia S Anand; Harry Shannon; Vladimir Vuksan; Bonnie Davis; Ruby Jacobs; Koon K Teo; Matthew McQueen; Salim Yusuf Journal: Circulation Date: 2007-04-09 Impact factor: 29.690
Authors: C Bouchard; R Lesage; G Lortie; J A Simoneau; P Hamel; M R Boulay; L Pérusse; G Thériault; C Leblanc Journal: Med Sci Sports Exerc Date: 1986-12 Impact factor: 5.411
Authors: Richard P Troiano; David Berrigan; Kevin W Dodd; Louise C Mâsse; Timothy Tilert; Margaret McDowell Journal: Med Sci Sports Exerc Date: 2008-01 Impact factor: 5.411
Authors: Carlos A Celis-Morales; Francisco Perez-Bravo; Luis Ibañez; Carlos Salas; Mark E S Bailey; Jason M R Gill Journal: PLoS One Date: 2012-05-09 Impact factor: 3.240
Authors: Miguel Cainzos-Achirica; Ugo Fedeli; Naveed Sattar; Charles Agyemang; Anne K Jenum; John W McEvoy; Jack D Murphy; Carlos Brotons; Roberto Elosua; Usama Bilal; Alka M Kanaya; Namratha R Kandula; Pablo Martinez-Amezcua; Josep Comin-Colet; Xavier Pinto Journal: Atherosclerosis Date: 2019-05-16 Impact factor: 5.162
Authors: Stamatina Iliodromiti; James McLaren; Nazim Ghouri; Melissa R Miller; Olof Dahlqvist Leinhard; Jennifer Linge; Stuart Ballantyne; Jonathan Platt; John Foster; Scott Hanvey; Unjali P Gujral; Alka Kanaya; Naveed Sattar; Mary Ann Lumsden; Jason M R Gill Journal: Diabetologia Date: 2022-10-13 Impact factor: 10.460
Authors: Nazim Ghouri; David Purves; Kevin A Deans; Greig Logan; Alex McConnachie; John Wilson; Jason M R Gill; Naveed Sattar Journal: PLoS One Date: 2015-04-17 Impact factor: 3.240
Authors: Tom Yates; Simon Griffin; Danielle H Bodicoat; Gwen Brierly; Helen Dallosso; Melanie J Davies; Helen Eborall; Charlotte Edwardson; Mike Gillett; Laura Gray; Wendy Hardeman; Sian Hill; Katie Morton; Stephen Sutton; Jacqui Troughton; Kamlesh Khunti Journal: Trials Date: 2015-07-02 Impact factor: 2.279
Authors: Sophie V Eastwood; Therese Tillin; Hakim-Moulay Dehbi; Andrew Wright; Nita G Forouhi; Ian Godsland; Peter Whincup; Naveed Sattar; Alun D Hughes; Nishi Chaturvedi Journal: Obesity (Silver Spring) Date: 2015-02-03 Impact factor: 5.002
Authors: Robert A Sloan; Susumu S Sawada; Daniel Girdano; Yi Tong Liu; Stuart J H Biddle; Steven N Blair Journal: BMC Public Health Date: 2013-09-24 Impact factor: 3.295