OBJECTIVE: Myocardial infarction (MI) is often preceded by severe chest pain. The use of inflammatory markers to distinguish between chest pain of cardiac and non cardiac origin are not well reported. The aim of the study was to distinguish the chest pain of non cardiac and cardiac origin by using reliable inflammatory markers. METHODS: The present study enrolled 80 subjects including chest pain which lead to myocardial infarction (n=40), non-cardiac chest pain (CP) patients (n=20) and healthy volunteers (N) (n=20). Leukotriene B4 (LTB4) and thromboxane B2 (TXB2) levels were analyzed along with hs-CRP. RESULTS: Receiver operating characteristic (ROC) curve analysis showed LTB4 and TXB2 to be a good discriminator between patients with chest pain of cardiac and non cardiac in origin. The area under the curve was found to be 0.988 and 0.925 for LTB4 and TXB2, respectively when compared with hs-CRP. The sensitivity and specificity of LTB4 and TXB2 were found to be 90, 85% and 95, 90%, respectively. CONCLUSION: The measurement of LTB4 and TXB2 levels may therefore be useful to distinguish the chest pain leading to MI from that of non cardiac in origin and for the management of the disease.
OBJECTIVE:Myocardial infarction (MI) is often preceded by severe chest pain. The use of inflammatory markers to distinguish between chest pain of cardiac and non cardiac origin are not well reported. The aim of the study was to distinguish the chest pain of non cardiac and cardiac origin by using reliable inflammatory markers. METHODS: The present study enrolled 80 subjects including chest pain which lead to myocardial infarction (n=40), non-cardiac chest pain (CP) patients (n=20) and healthy volunteers (N) (n=20). Leukotriene B4 (LTB4) and thromboxane B2 (TXB2) levels were analyzed along with hs-CRP. RESULTS: Receiver operating characteristic (ROC) curve analysis showed LTB4 and TXB2 to be a good discriminator between patients with chest pain of cardiac and non cardiac in origin. The area under the curve was found to be 0.988 and 0.925 for LTB4 and TXB2, respectively when compared with hs-CRP. The sensitivity and specificity of LTB4 and TXB2 were found to be 90, 85% and 95, 90%, respectively. CONCLUSION: The measurement of LTB4 and TXB2 levels may therefore be useful to distinguish the chest pain leading to MI from that of non cardiac in origin and for the management of the disease.
Authors: David M Iovannisci; Edward J Lammer; Lori Steiner; Suzanne Cheng; Larry T Mahoney; Patricia H Davis; Ronald M Lauer; Trudy L Burns Journal: Arterioscler Thromb Vasc Biol Date: 2006-11-16 Impact factor: 8.311
Authors: Eva Sánchez-Galán; Almudena Gómez-Hernández; Cristina Vidal; José Luis Martín-Ventura; Luis Miguel Blanco-Colio; Begoña Muñoz-García; Luis Ortega; Jesús Egido; José Tuñón Journal: Cardiovasc Res Date: 2008-10-13 Impact factor: 10.787
Authors: Anna Helgadottir; Andrei Manolescu; Gudmar Thorleifsson; Solveig Gretarsdottir; Helga Jonsdottir; Unnur Thorsteinsdottir; Nilesh J Samani; Gudmundur Gudmundsson; Struan F A Grant; Gudmundur Thorgeirsson; Sigurlaug Sveinbjornsdottir; Einar M Valdimarsson; Stefan E Matthiasson; Halldor Johannsson; Olof Gudmundsdottir; Mark E Gurney; Jesus Sainz; Margret Thorhallsdottir; Margret Andresdottir; Michael L Frigge; Eric J Topol; Augustine Kong; Vilmundur Gudnason; Hakon Hakonarson; Jeffrey R Gulcher; Kari Stefansson Journal: Nat Genet Date: 2004-02-08 Impact factor: 38.330
Authors: Jeroen B van der Net; Jorie Versmissen; Daniëlla M Oosterveer; Joep C Defesche; Mojgan Yazdanpanah; Bradley E Aouizerat; Ewout W Steyerberg; Mary J Malloy; Clive R Pullinger; John P Kane; John J P Kastelein; Eric J G Sijbrands Journal: Atherosclerosis Date: 2008-08-05 Impact factor: 5.162
Authors: Soeren E Pischke; A Gustavsen; H L Orrem; K H Egge; F Courivaud; H Fontenelle; A Despont; A K Bongoni; R Rieben; T I Tønnessen; M A Nunn; H Scott; H Skulstad; A Barratt-Due; T E Mollnes Journal: Basic Res Cardiol Date: 2017-03-03 Impact factor: 17.165