INTRODUCTION: High-protein (HP) diets might affect renal status. We aimed to examine the effects of a HP diet on plasma, urinary and morphological renal parameters in rats. MATERIAL AND METHODS: Twenty Wistar rats were randomly distributed in 2 experimental groups with HP or normal-protein (NP) diets over 12 weeks. RESULTS AND DISCUSSION: Final body weight was a 10%lower in the HP group (p < 0.05) whereas we have not observed differences on food intake, carcass weight and muscle ashes content. No significant clear differences were observed on plasma parameters, whereas urinary citrate was an 88% lower in the HP group (p = 0.001) and urinary pH a 15% more acidic (p < 0.001). Kidney wet mass was ~22 heavier in the HP group (p < 0.001). Renal mesangium area was a 32% higher in the HP group (p < 0.01). Glomerular 1 and 2 were also ~30 higher in the HP diet (p < 0.01 and p < 0.05, respectively) and glomerular area a 13% higher (p < 0.01). CONCLUSION: High-protein diet promoted a worse renal profile, especially on urinary and morphological markers, which could increase the risk for developing renal diseases in the long time.
INTRODUCTION: High-protein (HP) diets might affect renal status. We aimed to examine the effects of a HP diet on plasma, urinary and morphological renal parameters in rats. MATERIAL AND METHODS: Twenty Wistar rats were randomly distributed in 2 experimental groups with HP or normal-protein (NP) diets over 12 weeks. RESULTS AND DISCUSSION: Final body weight was a 10%lower in the HP group (p < 0.05) whereas we have not observed differences on food intake, carcass weight and muscle ashes content. No significant clear differences were observed on plasma parameters, whereas urinary citrate was an 88% lower in the HP group (p = 0.001) and urinary pH a 15% more acidic (p < 0.001). Kidney wet mass was ~22 heavier in the HP group (p < 0.001). Renal mesangium area was a 32% higher in the HP group (p < 0.01). Glomerular 1 and 2 were also ~30 higher in the HP diet (p < 0.01 and p < 0.05, respectively) and glomerular area a 13% higher (p < 0.01). CONCLUSION: High-protein diet promoted a worse renal profile, especially on urinary and morphological markers, which could increase the risk for developing renal diseases in the long time.
Authors: Pablo Steinberg; Hilko van der Voet; Paul W Goedhart; Gijs Kleter; Esther J Kok; Maria Pla; Anna Nadal; Dagmar Zeljenková; Radka Aláčová; Júlia Babincová; Eva Rollerová; Soňa Jaďuďová; Anton Kebis; Elena Szabova; Jana Tulinská; Aurélia Líšková; Melinda Takácsová; Miroslava Lehotská Mikušová; Zora Krivošíková; Armin Spök; Monica Racovita; Huib de Vriend; Roger Alison; Clare Alison; Wolfgang Baumgärtner; Kathrin Becker; Charlotte Lempp; Marion Schmicke; Dieter Schrenk; Annette Pöting; Joachim Schiemann; Ralf Wilhelm Journal: Arch Toxicol Date: 2019-02-12 Impact factor: 5.153
Authors: Patrik Simko; Andrea Leskanicova; Maria Suvakova; Alzbeta Blicharova; Martina Karasova; Michal Goga; Mariana Kolesarova; Bianka Bojkova; Petra Majerova; Nela Zidekova; Ivan Barvik; Andrej Kovac; Terezia Kiskova Journal: Life (Basel) Date: 2022-07-20