Literature DB >> 2380724

The cytotoxic principles of Solanum incanum.

C N Lin1, C M Lu, M K Cheng, K H Gan, S J Won.   

Abstract

In continuation of work on Solanum incanum a new steroidal alkaloid glycoside has been isolated from the fresh berries, which is named incanumine, and characterized as O(3)-[beta-D-xylopyranosyl-(1----3glu)-[beta-D-xylopyranosyl-(1--- -4rha)- alpha-L-rhamnopyranosyl-(1----4)]-beta-D-glucopyranosyl)-solasodine++ +. Solamargine, solasodine, ursolic acid, and ursolic acid derivatives (3-O-palmitoyl ursolic acid, 3-O-crotonyl ursolic acid, 3-O-propionyl ursolic acid) exhibited significant cytotoxic effects against human PLC/PRF/5 cells in vitro. Esterification of ursolic acid with aliphatic acids clearly enhanced the cytotoxic effects against human PLC/PRF/5 cells in vitro.

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Year:  1990        PMID： 2380724     DOI： 10.1021/np50068a041

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  8 in total

Review 1.  Chemistry and bioactivities of natural steroidal alkaloids.

Authors:  Mei-Ling Xiang; Bin-Yuan Hu; Zi-Heng Qi; Xiao-Na Wang; Tian-Zhen Xie; Zhao-Jie Wang; Dan-Yu Ma; Qi Zeng; Xiao-Dong Luo
Journal:  Nat Prod Bioprospect       Date:  2022-06-15

2.  Synthesis and anti-cancer activity of a glycosyl library of N-acetylglucosamine-bearing oleanolic acid.

Authors:  Yi-Bing Zeng; Hsin-Min Hsiao; She-Hung Chan; Ying-Hsin Wang; You-Yu Lin; Yu-Hsuan Kuo; Jih-Hwa Guh; Pi-Hui Liang
Journal:  Mol Divers       Date:  2013-09-25       Impact factor: 2.943

3.  Molluscicidal activity of various solvent extracts from Solanum nigrum var. villosum L. aerial parts against Galba truncatula.

Authors:  H Hammami; R Mezghani-Jarraya; M Damak; A Ayadi
Journal:  Parasite       Date:  2011-02       Impact factor: 3.000

4.  Nematicidal and antimicrobial activities of methanol extracts of 17 plants, of importance in ethnopharmacology, obtained from the Arabian Peninsula.

Authors:  Adel Al-Marby; Chukwunonso Ecc Ejike; Muhammad Jawad Nasim; Nasser A Awadh-Ali; Rwaida A Al-Badani; Ghanem Ma Alghamdi; Claus Jacob
Journal:  J Intercult Ethnopharmacol       Date:  2016-02-21

5.  Hyaluronidase Inhibitory Activity of Pentacylic Triterpenoids from Prismatomeris tetrandra (Roxb.) K. Schum: Isolation, Synthesis and QSAR Study.

Authors:  Nor Hayati Abdullah; Noel Francis Thomas; Yasodha Sivasothy; Vannajan Sanghiran Lee; Sook Yee Liew; Ibrahim Ali Noorbatcha; Khalijah Awang
Journal:  Int J Mol Sci       Date:  2016-02-14       Impact factor: 5.923

6.  Interspecies Anticancer and Antimicrobial Activities of Genus Solanum and Estimation of Rutin by Validated UPLC-PDA Method.

Authors:  Mohamed Fahad Alajmi; Perwez Alam; Md Tabish Rehman; Fohad Mabood Husain; Azmat Ali Khan; Nasir Ali Siddiqui; Afzal Hussain; Mohd Abul Kalam; Mohammad Khalid Parvez
Journal:  Evid Based Complement Alternat Med       Date:  2018-07-03       Impact factor: 2.629

7.  Chinese herbal medicines as a source of molecules with anti-enterovirus 71 activity.

Authors:  Mengjie Wang; Ling Tao; Hongxi Xu
Journal:  Chin Med       Date:  2016-01-28       Impact factor: 5.455

8.  UPLC-ESI-MS/MS and HPTLC Method for Quantitative Estimation of Cytotoxic Glycosides and Aglycone in Bioactivity Guided Fractions of Solanum nigrum L.

Authors:  Karishma Chester; Sarvesh Paliwal; Washim Khan; Sayeed Ahmad
Journal:  Front Pharmacol       Date:  2017-07-06       Impact factor: 5.810
  8 in total

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