| Literature DB >> 2380718 |
G R Pettit1, A Numata, T Takemura, R H Ode, A S Narula, J M Schmidt, G M Cragg, C P Pase.
Abstract
The southwestern Indian paintbrush, Castilleja linariaefolia, yielded extracts that displayed in vivo activity against murine P-388 (PS) lymphocytic leukemia. Separation guided by PS cell line inhibition led to isolation of cytotoxic compounds that were identified as the known glycosides acteoside [1] (ED50 2.6 micrograms/ml) and isoacteoside [2] (ED50 10 micrograms/ml). The identifications were established by spectral measurements and degradation studies. Mannitol was also found in this plant.Entities:
Mesh：
Substances：
Year: 1990 PMID： 2380718 DOI： 10.1021/np50068a026
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050