Literature DB >> 23807116

Molecular pharmacology of store-operated CRAC channels.

Amit Jairaman1, Murali Prakriya1.   

Abstract

Calcium influx through store-operated Ca(2+) release-activated Ca(2+) channels (CRAC channels) is a well-defined mechanism of generating cellular Ca(2+) elevations that regulates many functions including gene expression, exocytosis and cell proliferation. The identifications of the ER Ca(2+) sensing proteins, STIM1-2 and the CRAC channel proteins, Orai1-3, have led to improved understanding of the physiological roles and the activation mechanism of CRAC channels. Defects in CRAC channel function are associated with serious human diseases such as immunodeficiency and auto-immunity. In this review, we discuss several pharmacological modulators of CRAC channels, focusing specifically on the molecular mechanism of drug action and their utility in illuminating the mechanism of CRAC channel operation and their physiological roles in different cells.

Entities:  

Keywords:  CRAC channel; Orai1; SOCE; STIM1; pharmacology

Mesh：

Substances：

Year:  2013        PMID： 23807116      PMCID： PMC3913763          DOI： 10.4161/chan.25292

Source DB:  PubMed          Journal:  Channels (Austin)        ISSN： 1933-6950            Impact factor:   2.581


  145 in total

1.  Gene regulation mediated by calcium signals in T lymphocytes.

Authors:  S Feske; J Giltnane; R Dolmetsch; L M Staudt; A Rao
Journal:  Nat Immunol       Date:  2001-04       Impact factor: 25.606

2.  Requirement of the inositol trisphosphate receptor for activation of store-operated Ca2+ channels.

Authors:  H T Ma; R L Patterson; D B van Rossum; L Birnbaumer; K Mikoshiba; D L Gill
Journal:  Science       Date:  2000-03-03       Impact factor: 47.728

3.  Monovalent cation permeability and Ca(2+) block of the store-operated Ca(2+) current I(CRAC )in rat basophilic leukemia cells.

Authors:  Daniel Bakowski; Anant B Parekh
Journal:  Pflugers Arch       Date:  2002-01-22       Impact factor: 3.657

4.  Ca2+ entry mediated by store depletion, S-nitrosylation, and TRP3 channels. Comparison of coupling and function.

Authors:  D B van Rossum; R L Patterson; H T Ma; D L Gill
Journal:  J Biol Chem       Date:  2000-09-15       Impact factor: 5.157

5.  Modification of store-operated channel coupling and inositol trisphosphate receptor function by 2-aminoethoxydiphenyl borate in DT40 lymphocytes.

Authors:  Hong-Tao Ma; Kartik Venkatachalam; Jan B Parys; Donald L Gill
Journal:  J Biol Chem       Date:  2001-12-10       Impact factor: 5.157

6.  Potent inhibition of NFAT activation and T cell cytokine production by novel low molecular weight pyrazole compounds.

Authors:  J M Trevillyan; X G Chiou; Y W Chen; S J Ballaron; M P Sheets; M L Smith; P E Wiedeman; U Warrior; J Wilkins; E J Gubbins; G D Gagne; J Fagerland; G W Carter; J R Luly; K W Mollison; S W Djuric
Journal:  J Biol Chem       Date:  2001-10-09       Impact factor: 5.157

7.  3,5-Bis(trifluoromethyl)pyrazoles: a novel class of NFAT transcription factor regulator.

Authors:  S W Djuric; N Y BaMaung; A Basha; H Liu; J R Luly; D J Madar; R J Sciotti; N P Tu; F L Wagenaar; P E Wiedeman; X Zhou; S Ballaron; J Bauch; Y W Chen; X G Chiou; T Fey; D Gauvin; E Gubbins; G C Hsieh; K C Marsh; K W Mollison; M Pong; T K Shaughnessy; M P Sheets; M Smith; J M Trevillyan; U Warrior; C D Wegner; G W Carter
Journal:  J Med Chem       Date:  2000-08-10       Impact factor: 7.446

8.  Potentiation and inhibition of Ca(2+) release-activated Ca(2+) channels by 2-aminoethyldiphenyl borate (2-APB) occurs independently of IP(3) receptors.

Authors:  M Prakriya; R S Lewis
Journal:  J Physiol       Date:  2001-10-01       Impact factor: 5.182

Review 9.  The TRP ion channel family.

Authors:  D E Clapham; L W Runnels; C Strübing
Journal:  Nat Rev Neurosci       Date:  2001-06       Impact factor: 34.870

10.  Exon structure and promoter identification of STIM1 (alias GOK), a human gene causing growth arrest of the human tumor cell lines G401 and RD.

Authors:  S Sabbioni; A Veronese; M Trubia; R Taramelli; G Barbanti-Brodano; C M Croce; M Negrini
Journal:  Cytogenet Cell Genet       Date:  1999
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  35 in total

Review 1.  Store-Operated Calcium Channels.

Authors:  Murali Prakriya; Richard S Lewis
Journal:  Physiol Rev       Date:  2015-10       Impact factor: 37.312

2.  Store-operated calcium entry is required for sustained contraction and Ca2+ oscillations of airway smooth muscle.

Authors:  Jun Chen; Michael J Sanderson
Journal:  J Physiol       Date:  2016-08-02       Impact factor: 5.182

3.  T-Type voltage-sensitive calcium channels mediate mechanically-induced intracellular calcium oscillations in osteocytes by regulating endoplasmic reticulum calcium dynamics.

Authors:  Genevieve N Brown; Pui L Leong; X Edward Guo
Journal:  Bone       Date:  2016-04-21       Impact factor: 4.398

4.  Store-operated CRAC channels regulate gene expression and proliferation in neural progenitor cells.

Authors:  Agila Somasundaram; Andrew K Shum; Helen J McBride; John A Kessler; Stefan Feske; Richard J Miller; Murali Prakriya
Journal:  J Neurosci       Date:  2014-07-02       Impact factor: 6.167

5.  CRAC channels regulate astrocyte Ca2+ signaling and gliotransmitter release to modulate hippocampal GABAergic transmission.

Authors:  Anna B Toth; Kotaro Hori; Michaela M Novakovic; Natalie G Bernstein; Laurie Lambot; Murali Prakriya
Journal:  Sci Signal       Date:  2019-05-21       Impact factor: 8.192

Review 6.  Store-operated CRAC channel inhibitors: opportunities and challenges.

Authors:  Chengsen Tian; Lupei Du; Yubin Zhou; Minyong Li
Journal:  Future Med Chem       Date:  2016-05-05       Impact factor: 3.808

7.  Stromal Interaction Molecule 1 (STIM1) Regulates ATP-sensitive Potassium (KATP) and Store-operated Ca2+ Channels in MIN6 β-Cells.

Authors:  Colin A Leech; Richard F Kopp; Heather A Nelson; Jyotirmoy Nandi; Michael W Roe
Journal:  J Biol Chem       Date:  2016-12-21       Impact factor: 5.157

8.  Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity.

Authors:  Scott M Emrich; Ryan E Yoast; Ping Xin; Xuexin Zhang; Trayambak Pathak; Robert Nwokonko; Maxime F Gueguinou; Krishna P Subedi; Yandong Zhou; Indu S Ambudkar; Nadine Hempel; Khaled Machaca; Donald L Gill; Mohamed Trebak
Journal:  J Biol Chem       Date:  2019-03-01       Impact factor: 5.157

9.  The effect of chlorpromazine on intracellular Ca2+ concentration in macrophages.

Authors:  Z I Krutetskaya; L S Milenina; A A Naumova; S N Butov; V G Antonov; A D Nozdrachev
Journal:  Dokl Biochem Biophys       Date:  2017-07-20       Impact factor: 0.788

10.  ER stress increases store-operated Ca2+ entry (SOCE) and augments basal insulin secretion in pancreatic beta cells.

Authors:  Irina X Zhang; Jianhua Ren; Suryakiran Vadrevu; Malini Raghavan; Leslie S Satin
Journal:  J Biol Chem       Date:  2020-03-16       Impact factor: 5.157
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