Literature DB >> 28726103

The effect of chlorpromazine on intracellular Ca2+ concentration in macrophages.

Z I Krutetskaya1, L S Milenina2, A A Naumova2, S N Butov2, V G Antonov2, A D Nozdrachev2.   

Abstract

Using Fura-2AM microfluorimetry, it was shown for the first time that neuroleptic chlorpromazine causes intracellular Ca2+ concentration increase in macrophages due to Ca2+ mobilization from intracellular Ca2+ stores and subsequent Ca2+ entry from the external medium. Chlorpromazine-induced Ca2+ entry is inhibited by La3+ and 2-aminoethoxydiphenyl borate and is associated with Ca2+ store depletion.

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Year:  2017        PMID： 28726103     DOI： 10.1134/S1607672917030036

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  13 in total

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Journal:  Mol Cell Biochem       Date:  1999-08       Impact factor: 3.396

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7.  Calcium influx factor from cytochrome P-450 metabolism and secretion-like coupling mechanisms for capacitative calcium entry in corneal endothelial cells.

Authors:  Qiang Xie; Yan Zhang; Changbin Zhai; Joseph A Bonanno
Journal:  J Biol Chem       Date:  2002-02-26       Impact factor: 5.157

8.  [The effect of cyclooxygenase and lipoxygenase inhibitors on Ca(2+)-responses induced by glutoxim and molixan in macrophages].

Authors:  L S Kurilova; Z I Krutetskaia; A A Naumova; S N Butov; N I Krutetskaia; V G Antonov
Journal:  Tsitologiia       Date:  2014

9.  Selective amphipathic nature of chlorpromazine binding to plasma membrane bilayers.

Authors:  James Y Chen; Linda S Brunauer; Felicia C Chu; Colleen M Helsel; Margaret M Gedde; Wray H Huestis
Journal:  Biochim Biophys Acta       Date:  2003-09-22

10.  Changes of intracellular free Ca2+ in macrophages following N-formyl chemotactic peptide stimulation. Direct measurement by the loading of quin 2.

Authors:  M Hirata; T Hashimoto; T Hamachi; T Koga
Journal:  J Biochem       Date:  1984-07       Impact factor: 3.387
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  2 in total

1.  Neuroleptic Chlorpromazine Modulates Ca2+ Responses in Macrophages.

Authors:  Z I Krutetskaya; L S Milenina; V G Antonov; A D Nozdrachev
Journal:  Dokl Biochem Biophys       Date:  2020-04-27       Impact factor: 0.788

2.  The Impact of the Antipsychotic Medication Chlorpromazine on Cytotoxicity through Ca2+ Signaling Pathway in Glial Cell Models.

Authors:  Che-Sheng Chu; Yung-Shang Lin; Wei-Zhe Liang
Journal:  Neurotox Res       Date:  2022-04-19       Impact factor: 3.911
  2 in total

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