| Literature DB >> 23806562 |
Qing Zhu1, Mei Liu, Liping Dai, Xia Ying, Hua Ye, Yusen Zhou, Suxia Han, Jian-Ying Zhang.
Abstract
Since intracellular proteins involved in carcinogenesis have been shown to provoke autoantibody responses, autoantibodies can be used as probes in immunoproteomics to isolate, identify, and characterize potential tumor-associated antigens (TAAs). Once a TAA is identified, several approaches will be used to comprehensively characterize and validate the identified TAA/anti-TAA systems that are potential biomarkers in certain types of cancer. Our ultimate goal is to establish rigorous criteria for designation of an autoantibody to a TAA as a cancer biomarker, examine candidate TAAs for sensitivity and specificity of anti-TAA antibody response, and further develop customized TAA arrays that can be used to enhance anti-TAA antibody detection in cancer. This review will mainly focus on the recent advances in our studies using immunoproteomic approach to identify and characterize TAAs as biomarkers in cancer.Entities:
Keywords: Autoantibody; Cancer; Immunodiagnosis; Immunoproteomics; Tumor-associated antigen
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Year: 2013 PMID： 23806562 PMCID： PMC3789855 DOI： 10.1016/j.autrev.2013.06.015
Source DB: PubMed Journal: Autoimmun Rev ISSN： 1568-9972 Impact factor: 9.754