Literature DB >> 23803606

Chaperonin-mediated protein folding.

Arthur L Horwich1.   

Abstract

We have been studying chaperonins these past twenty years through an initial discovery of an action in protein folding, analysis of structure, and elucidation of mechanism. Some of the highlights of these studies were presented recently upon sharing the honor of the 2013 Herbert Tabor Award with my early collaborator, Ulrich Hartl, at the annual meeting of the American Society for Biochemistry and Molecular Biology in Boston. Here, some of the major findings are recounted, particularly recognizing my collaborators, describing how I met them and how our great times together propelled our thinking and experiments.

Keywords:  Chaperone Chaperonin; Molecular Chaperone; Polypeptide; Protein Folding; Protein Misfolding; Yeast

Mesh:

Substances:

Year:  2013        PMID: 23803606      PMCID: PMC3745308          DOI: 10.1074/jbc.X113.497321

Source DB:  PubMed          Journal:  J Biol Chem        ISSN: 0021-9258            Impact factor:   5.157


  44 in total

1.  Multivalent binding of nonnative substrate proteins by the chaperonin GroEL.

Authors:  G W Farr; K Furtak; M B Rowland; N A Ranson; H R Saibil; T Kirchhausen; A L Horwich
Journal:  Cell       Date:  2000-03-03       Impact factor: 41.582

2.  NMR analysis of a 900K GroEL GroES complex.

Authors:  Jocelyne Fiaux; Eric B Bertelsen; Arthur L Horwich; Kurt Wüthrich
Journal:  Nature       Date:  2002-07-11       Impact factor: 49.962

3.  Cytochromes c1 and b2 are sorted to the intermembrane space of yeast mitochondria by a stop-transfer mechanism.

Authors:  B S Glick; A Brandt; K Cunningham; S Müller; R L Hallberg; G Schatz
Journal:  Cell       Date:  1992-05-29       Impact factor: 41.582

4.  ATP induces large quaternary rearrangements in a cage-like chaperonin structure.

Authors:  H R Saibil; D Zheng; A M Roseman; A S Hunter; G M Watson; S Chen; A Auf Der Mauer; B P O'Hara; S P Wood; N H Mann; L K Barnett; R J Ellis
Journal:  Curr Biol       Date:  1993-05-01       Impact factor: 10.834

5.  Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis.

Authors:  J Ostermann; A L Horwich; W Neupert; F U Hartl
Journal:  Nature       Date:  1989-09-14       Impact factor: 49.962

6.  Conformational variability in the refined structure of the chaperonin GroEL at 2.8 A resolution.

Authors:  K Braig; P D Adams; A T Brünger
Journal:  Nat Struct Biol       Date:  1995-12

7.  Chaperonin-mediated protein folding at the surface of groEL through a 'molten globule'-like intermediate.

Authors:  J Martin; T Langer; R Boteva; A Schramel; A L Horwich; F U Hartl
Journal:  Nature       Date:  1991-07-04       Impact factor: 49.962

8.  Mechanism of GroEL action: productive release of polypeptide from a sequestered position under GroES.

Authors:  J S Weissman; C M Hohl; O Kovalenko; Y Kashi; S Chen; K Braig; H R Saibil; W A Fenton; A L Horwich
Journal:  Cell       Date:  1995-11-17       Impact factor: 41.582

9.  Folding trajectories of human dihydrofolate reductase inside the GroEL GroES chaperonin cavity and free in solution.

Authors:  Reto Horst; Wayne A Fenton; S Walter Englander; Kurt Wüthrich; Arthur L Horwich
Journal:  Proc Natl Acad Sci U S A       Date:  2007-12-19       Impact factor: 11.205

Review 10.  Dynamics of the chaperonin ATPase cycle: implications for facilitated protein folding.

Authors:  M J Todd; P V Viitanen; G H Lorimer
Journal:  Science       Date:  1994-07-29       Impact factor: 47.728

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  5 in total

Review 1.  Chaperome heterogeneity and its implications for cancer study and treatment.

Authors:  Tai Wang; Anna Rodina; Mark P Dunphy; Adriana Corben; Shanu Modi; Monica L Guzman; Daniel T Gewirth; Gabriela Chiosis
Journal:  J Biol Chem       Date:  2018-11-08       Impact factor: 5.157

Review 2.  A second chance for protein targeting/folding: Ubiquitination and deubiquitination of nascent proteins.

Authors:  Jacob A Culver; Xia Li; Matthew Jordan; Malaiyalam Mariappan
Journal:  Bioessays       Date:  2022-03-31       Impact factor: 4.653

Review 3.  Chloroplast Chaperonin: An Intricate Protein Folding Machine for Photosynthesis.

Authors:  Qian Zhao; Cuimin Liu
Journal:  Front Mol Biosci       Date:  2018-01-19

4.  Structural insight into the cooperation of chloroplast chaperonin subunits.

Authors:  Shijia Zhang; Huan Zhou; Feng Yu; Cuicui Bai; Qian Zhao; Jianhua He; Cuimin Liu
Journal:  BMC Biol       Date:  2016-04-12       Impact factor: 7.431

Review 5.  Disease-Associated Mutations in the HSPD1 Gene Encoding the Large Subunit of the Mitochondrial HSP60/HSP10 Chaperonin Complex.

Authors:  Peter Bross; Paula Fernandez-Guerra
Journal:  Front Mol Biosci       Date:  2016-08-31
  5 in total

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