BACKGROUND: The ABO blood groups and Rh factor may affect the risk of lung cancer. MATERIALS AND METHODS: We analyzed 2,044 lung cancer patients with serologically confirmed ABO/Rh blood group. A group of 3,022,883 healthy blood donors of Turkish Red Crescent was identified as a control group. We compared the distributions of ABO/Rh blood group between them. RESULTS: The median age was 62 years (range: 17-90). There was a clear male predominance (84% vs. 16%). Overall distributions of ABO blood groups were significantly different between patients and controls (p=0.01). There were also significant differences between patients and controls with respect to Rh positive vs. Rh negative (p=0.04) and O vs. non-O (p=0.002). There were no statistically significant differences of blood groups with respect to sex, age, or histology. CONCLUSIONS: In the study population, ABO blood types were associated with the lung cancer. Having non-O blood type and Rh-negative feature increased the risk of lung cancer. However, further prospective studies are necessary to define the mechanisms by which ABO blood type may influence the lung cancer risk.
BACKGROUND: The ABO blood groups and Rh factor may affect the risk of lung cancer. MATERIALS AND METHODS: We analyzed 2,044 lung cancerpatients with serologically confirmed ABO/Rh blood group. A group of 3,022,883 healthy blood donors of Turkish Red Crescent was identified as a control group. We compared the distributions of ABO/Rh blood group between them. RESULTS: The median age was 62 years (range: 17-90). There was a clear male predominance (84% vs. 16%). Overall distributions of ABO blood groups were significantly different between patients and controls (p=0.01). There were also significant differences between patients and controls with respect to Rh positive vs. Rh negative (p=0.04) and O vs. non-O (p=0.002). There were no statistically significant differences of blood groups with respect to sex, age, or histology. CONCLUSIONS: In the study population, ABO blood types were associated with the lung cancer. Having non-O blood type and Rh-negative feature increased the risk of lung cancer. However, further prospective studies are necessary to define the mechanisms by which ABO blood type may influence the lung cancer risk.
Authors: Mohammed Z Allouh; Mohammed M Al Barbarawi; Mohammad Y Hiasat; Mohammed A Al-Qaralleh; Emad I Ababneh Journal: Blood Transfus Date: 2016-06-30 Impact factor: 3.443
Authors: Céline Montavon Sartorius; Andreas Schoetzau; Henriette Kettelhack; Daniel Fink; Neville F Hacker; André Fedier; Francis Jacob; Viola Heinzelmann-Schwarz Journal: PLoS One Date: 2018-03-29 Impact factor: 3.240