Literature DB >> 23800690

Different strategies to overcome multidrug resistance in cancer.

Manju Saraswathy1, Shaoqin Gong.   

Abstract

The risk of acquisition of resistance to chemotherapy remains a major hurdle in the management of various types of cancer patients. Several cellular and noncellular mechanisms are involved in developing both intrinsic and acquired resistance in cancer cells toward chemotherapy. This review covers the various multidrug resistance (MDR) mechanisms observed in cancer cells as well as the various strategies developed to overcome these MDR mechanisms. Extensive studies have been conducted during the last several decades to enhance the efficacy of chemotherapy by suppressing or evading these MDR mechanisms including the use of new anticancer drugs that could escape from the efflux reaction, MDR modulators or chemosensitizers, multifunctional nanocarriers, and RNA interference (RNAi) therapy.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Anticancer agents; Cancer; Chemosensitizers; Multidrug resistance; Nanocarriers; RNAi therapy

Mesh：

Substances：

Year:  2013        PMID： 23800690     DOI： 10.1016/j.biotechadv.2013.06.004

Source DB:  PubMed          Journal:  Biotechnol Adv        ISSN： 0734-9750            Impact factor:   14.227


  56 in total

1.  Synthetic and Biological Studies of Sesquiterpene Polygodial: Activity of 9-Epipolygodial against Drug-Resistant Cancer Cells.

Authors:  Ramesh Dasari; Annelise De Carvalho; Derek C Medellin; Kelsey N Middleton; Frédéric Hague; Marie N M Volmar; Liliya V Frolova; Mateus F Rossato; Jorge J De La Chapa; Nicholas F Dybdal-Hargreaves; Akshita Pillai; Véronique Mathieu; Snezna Rogelj; Cara B Gonzales; João B Calixto; Antonio Evidente; Mathieu Gautier; Gnanasekar Munirathinam; Rainer Glass; Patricia Burth; Stephen C Pelly; Willem A L van Otterlo; Robert Kiss; Alexander Kornienko
Journal:  ChemMedChem       Date:  2015-10-05       Impact factor: 3.466

Review 2.  Positron emission tomography diagnostic imaging in multidrug-resistant hepatocellular carcinoma: focus on 2-deoxy-2-(18F)Fluoro-D-Glucose.

Authors:  Ana F Brito; Mónica Mendes; Ana M Abrantes; José G Tralhão; Maria F Botelho
Journal:  Mol Diagn Ther       Date:  2014-10       Impact factor: 4.074

3.  DJ-1 Alters Epirubicin-induced Apoptosis via Modulating Epirubicinactivated Autophagy in Human Gastric Cancer Cells.

Authors:  Xue-Kai Pan; Fei Su; Li-Hua Xu; Zhang-Shuo Yang; Dan-Wen Wang; Li-Jie Yang; Fan-Zheng Kong; Wei Xie; Mao-Hui Feng
Journal:  Curr Med Sci       Date:  2018-12-07

Review 4.  Multifunctional nanoparticles for cancer immunotherapy.

Authors:  Tayebeh Saleh; Seyed Abbas Shojaosadati
Journal:  Hum Vaccin Immunother       Date:  2016-02-22       Impact factor: 3.452

5.  Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells.

Authors:  Alexander V Aksenov; Alexander N Smirnov; Igor V Magedov; Mary R Reisenauer; Nicolai A Aksenov; Inna V Aksenova; Alexander L Pendleton; Gina Nguyen; Robert K Johnston; Michael Rubin; Annelise De Carvalho; Robert Kiss; Véronique Mathieu; Florence Lefranc; Jaime Correa; David A Cavazos; Andrew J Brenner; Brad A Bryan; Snezna Rogelj; Alexander Kornienko; Liliya V Frolova
Journal:  J Med Chem       Date:  2015-02-20       Impact factor: 7.446

6.  Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins: Exploration of the N3 and N9 Positions and Interaction with Multidrug-Resistance Proteins.

Authors:  Ramesh Dasari; Andrzej Błauż; Derek C Medellin; Roaa M Kassim; Carlos Viera; Maximo Santarosa; Alet E van der Westhuyzen; Willem A L van Otterlo; Taryn Olivas; Tugba Yildiz; Tania Betancourt; Charles B Shuster; Snezna Rogelj; Błażej Rychlik; Todd Hudnall; Liliya V Frolova; Alexander Kornienko
Journal:  ChemMedChem       Date:  2019-01-25       Impact factor: 3.466

7.  Codelivery of doxorubicin and curcumin with lipid nanoparticles results in improved efficacy of chemotherapy in liver cancer.

Authors:  Xiaojing Zhao; Qi Chen; Wei Liu; Yusang Li; Hebin Tang; Xuhan Liu; Xiangliang Yang
Journal:  Int J Nanomedicine       Date:  2014-12-30

8.  [Diltiazem inhibits proliferation and motility of hepatocellular cells in vitro by downregulating calcium-activated chloride channel TMEM16A].

Authors:  Rui Guo; Xiaozhong Huang; Xueyuan Jin; Jun Yang
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2018-07-30

9.  Nitric oxide: Friend or Foe in Cancer Chemotherapy and Drug Resistance: A Perspective.

Authors:  Birandra K Sinha
Journal:  J Cancer Sci Ther       Date:  2016-10-28

10.  A Nonquiescent "Idling" Population State in Drug-Treated, BRAF-Mutated Melanoma.

Authors:  B Bishal Paudel; Leonard A Harris; Keisha N Hardeman; Arwa A Abugable; Corey E Hayford; Darren R Tyson; Vito Quaranta
Journal:  Biophys J       Date:  2018-03-27       Impact factor: 4.033
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