| Literature DB >> 2380019 |
M B Edelstein1, J J Crowley, F A Valeriote, J D Bonnet, J O Carden, R C Khanna, S E Salmon, J S Ungerleider.
Abstract
Thirty-three patients with relapsing or refractory multiple myeloma were treated with 6-Thioguanine (6TG) at a dose of 1 g/M2, with therapy given over four hours every three weeks. The major toxicity seen was myelotoxicity; thrombocytopenia was more commonly noted than neutropenia. One patient achieved a PR, two were clinically improved. 6TG in this short infusion schedule proved to be myelotoxic, but demonstrated little activity in previously treated myeloma patients.Entities:
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Year: 1990 PMID： 2380019 DOI： 10.1007/bf00171990
Source DB: PubMed Journal: Invest New Drugs ISSN： 0167-6997 Impact factor: 3.850