Literature DB >> 23799569

Mathematical models of morphogen gradients and their effects on gene expression.

Stanislav Y Shvartsman1, Ruth E Baker.   

Abstract

An introduction to mathematical models of pattern formation by morphogen gradients is presented, using the early embryo of the fruit fly Drosophila as the main experimental example. Analysis of morphogen gradient formation is based on the source-diffusion-degradation models and a formalism of local accumulation times. Transcriptional control by morphogens is discussed within the framework of thermodynamic site occupancy models of gene regulatory regions.
Copyright © 2012 Wiley Periodicals, Inc.

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Year:  2012        PMID： 23799569     DOI： 10.1002/wdev.55

Source DB:  PubMed          Journal:  Wiley Interdiscip Rev Dev Biol        ISSN： 1759-7684            Impact factor:   5.814


  6 in total

1.  Synthesis and materialization of a reaction-diffusion French flag pattern.

Authors:  Anton S Zadorin; Yannick Rondelez; Guillaume Gines; Vadim Dilhas; Georg Urtel; Adrian Zambrano; Jean-Christophe Galas; André Estevez-Torres
Journal:  Nat Chem       Date:  2017-05-01       Impact factor: 24.427

2.  Mad dephosphorylation at the nuclear pore is essential for asymmetric stem cell division.

Authors:  Justin Sardi; Muhammed Burak Bener; Taylor Simao; Abigail E Descoteaux; Boris M Slepchenko; Mayu Inaba
Journal:  Proc Natl Acad Sci U S A       Date:  2021-03-30       Impact factor: 11.205

Review 3.  The importance of geometry in mathematical models of developing systems.

Authors:  David M Umulis; Hans G Othmer
Journal:  Curr Opin Genet Dev       Date:  2012-10-27       Impact factor: 5.578

4.  Modeling protein dynamics in Caenorhabditis elegans embryos reveals that the PLK-1 gradient relies on weakly coupled reaction-diffusion mechanisms.

Authors:  Sofia Barbieri; Aparna Nurni Ravi; Erik E Griffin; Monica Gotta
Journal:  Proc Natl Acad Sci U S A       Date:  2022-03-08       Impact factor: 12.779

5.  Rewiring MAP kinases in Saccharomyces cerevisiae to regulate novel targets through ubiquitination.

Authors:  Benjamin Groves; Arjun Khakhar; Cory M Nadel; Richard G Gardner; Georg Seelig
Journal:  Elife       Date:  2016-08-15       Impact factor: 8.140

6.  Diffusion vs. direct transport in the precision of morphogen readout.

Authors:  Sean Fancher; Andrew Mugler
Journal:  Elife       Date:  2020-10-14       Impact factor: 8.140
  6 in total

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