Carla M M Prado1. 1. Department of Nutrition, Food, and Exercise Sciences The Florida State University, Tallahassee, FL 32306, USA. cprado@fsu.edu
Abstract
PURPOSE OF REVIEW: Reducing cancer-treatment toxicity was a largely ignored research agenda, which is now emerging as an active area of investigation. Studies of human body composition using computerized tomography scans have provided proof-of-concept that variability in drug disposition and toxicity profiles may be partially explained by different features in body composition. RECENT FINDINGS: Collectively, studies suggest that skeletal muscle depletion (regardless of body weight) is an independent predictor of severe toxicity, affecting cancer treatment and its outcomes. Although precise mechanisms are unknown, pharmacokinetic parameters such as variations in volume of distribution and increased drug exposure may explain such findings. SUMMARY: Computerized tomography scans are readily available in clinical databases of diagnostic images and provide feasible, reliable, and highly differentiated measurements of body composition. These images should be used to optimize screening and management of patients in order to prevent severe toxicity, and to improve the efficacy and cost-efficiency of chemotherapy treatments.
PURPOSE OF REVIEW: Reducing cancer-treatment toxicity was a largely ignored research agenda, which is now emerging as an active area of investigation. Studies of human body composition using computerized tomography scans have provided proof-of-concept that variability in drug disposition and toxicity profiles may be partially explained by different features in body composition. RECENT FINDINGS: Collectively, studies suggest that skeletal muscle depletion (regardless of body weight) is an independent predictor of severe toxicity, affecting cancer treatment and its outcomes. Although precise mechanisms are unknown, pharmacokinetic parameters such as variations in volume of distribution and increased drug exposure may explain such findings. SUMMARY: Computerized tomography scans are readily available in clinical databases of diagnostic images and provide feasible, reliable, and highly differentiated measurements of body composition. These images should be used to optimize screening and management of patients in order to prevent severe toxicity, and to improve the efficacy and cost-efficiency of chemotherapy treatments.
Authors: P Cresta Morgado; M Daud; M Carballido; G Méndez; S Iseas; V Lobbe; G De Simone; A Navigante Journal: Support Care Cancer Date: 2018-08-18 Impact factor: 3.603
Authors: Sergio Setsuo Maeda; Barbara Santarosa Emo Peters; Lígia Araújo Martini; Hannah Karen Moreira Antunes; Maria Cristina Gonzalez; Henrique Pierotti Arantes; Carla M Prado; Camila Lemos Pinto; Iana Mizumukai de Araújo; Francisco José Albuquerque de Paula; Joao Lindolfo Cunha Borges; Ben-Hur Albergaria; Marcela Ushida; Guilherme Cardenaz de Souza; Laura Maria Carvalho de Mendonça; Mirley do Prado; Marcelo de Medeiros Pinheiro Journal: Adv Rheumatol Date: 2022-03-20
Authors: Elizabeth M Cespedes Feliciano; Candyce H Kroenke; Patrick T Bradshaw; Wendy Y Chen; Carla M Prado; Erin K Weltzien; Adrienne L Castillo; Bette J Caan Journal: Cancer Epidemiol Biomarkers Prev Date: 2016-08-26 Impact factor: 4.254
Authors: C M Lack; G J Lesser; U N Umesi; J Bowns; M Y Chen; D Case; R C Hightower; A J Johnson Journal: Clin Radiol Date: 2016-01-12 Impact factor: 2.350
Authors: Elizabeth M Cespedes Feliciano; Valerie S Lee; Carla M Prado; Jeffrey A Meyerhardt; Stacey Alexeeff; Candyce H Kroenke; Jingjie Xiao; Adrienne L Castillo; Bette J Caan Journal: Cancer Date: 2017-09-07 Impact factor: 6.860
Authors: Bárbara Ferrão; Pedro Miguel Neves; Teresa Santos; Manuel Luís Capelas; Antti Mäkitie; Paula Ravasco Journal: Support Care Cancer Date: 2020-06-13 Impact factor: 3.603
Authors: Tim A Labeur; Jeroen L A van Vugt; David W G Ten Cate; R Bart Takkenberg; Jan N M IJzermans; Bas Groot Koerkamp; Robert A de Man; Otto M van Delden; Ferry A L M Eskens; Heinz-Josef Klümpen Journal: Liver Cancer Date: 2018-11-02 Impact factor: 11.740