AIMS: To assess the relationship between pain and HbA(1c) levels in a predominantly black population with diabetes, and to determine whether self-management behaviours (exercise and diet) and symptoms of depression mediate this relationship. METHODS: We analysed cross-sectional data from 417 community-dwelling individuals with diabetes in rural Alabama, USA. Binary logistic regression was used to analyse the relationship between pain and HbA(1c) levels, defined as relatively good [≤ 64 mmol/mol (≤ 8.0%)] and relatively poor [> 64 mmol/mol (> 8.0%)], after adjusting for sociodemographics, insulin use, medication count, cigarette smoking history and body mass index (BMI). We examined the mediating roles of exercise, diet, and symptoms of depression using bootstrapping. RESULTS: Participants were primarily black (86.6%), female (76.1%) and reported an annual income of ≤$20,000 (52.7%). Their mean (sd) age was 59.6 (12.8) years. The majority of the participants reported moderate to extreme pain (71.5%). Participants reporting pain were more than twice as likely to have HbA(1c) levels > 64 mmol/mol (8.0%) in the fully adjusted model (odds ratio 2.33 [95% CI 1.28-4.24]; P < 0.05). Diet significantly mediated the relationship between pain and HbA(1c) control (β = 0.06; 95% CI: 0.01-0.17), but only in the unadjusted model. Exercise and symptoms of depression were not significant mediators. CONCLUSIONS: A significant independent relationship between pain and HbA(1c) control was found in this mainly black population, which was not explained by self-management behaviours or symptoms of depression. Future research is needed to delineate the mechanism by which pain influences HbA(1c) control, especially among black people with diabetes on low incomes.
AIMS: To assess the relationship between pain and HbA(1c) levels in a predominantly black population with diabetes, and to determine whether self-management behaviours (exercise and diet) and symptoms of depression mediate this relationship. METHODS: We analysed cross-sectional data from 417 community-dwelling individuals with diabetes in rural Alabama, USA. Binary logistic regression was used to analyse the relationship between pain and HbA(1c) levels, defined as relatively good [≤ 64 mmol/mol (≤ 8.0%)] and relatively poor [> 64 mmol/mol (> 8.0%)], after adjusting for sociodemographics, insulin use, medication count, cigarette smoking history and body mass index (BMI). We examined the mediating roles of exercise, diet, and symptoms of depression using bootstrapping. RESULTS:Participants were primarily black (86.6%), female (76.1%) and reported an annual income of ≤$20,000 (52.7%). Their mean (sd) age was 59.6 (12.8) years. The majority of the participants reported moderate to extreme pain (71.5%). Participants reporting pain were more than twice as likely to have HbA(1c) levels > 64 mmol/mol (8.0%) in the fully adjusted model (odds ratio 2.33 [95% CI 1.28-4.24]; P < 0.05). Diet significantly mediated the relationship between pain and HbA(1c) control (β = 0.06; 95% CI: 0.01-0.17), but only in the unadjusted model. Exercise and symptoms of depression were not significant mediators. CONCLUSIONS: A significant independent relationship between pain and HbA(1c) control was found in this mainly black population, which was not explained by self-management behaviours or symptoms of depression. Future research is needed to delineate the mechanism by which pain influences HbA(1c) control, especially among black people with diabetes on low incomes.
Authors: Kelli D Allen; Jiu-Chiuan Chen; Leigh F Callahan; Yvonne M Golightly; Charles G Helmick; Jordan B Renner; Todd A Schwartz; Joanne M Jordan Journal: J Rheumatol Date: 2011-12-01 Impact factor: 4.666
Authors: W Ken Redekop; Marc A Koopmanschap; Ronald P Stolk; Guy E H M Rutten; Bruce H R Wolffenbuttel; Louis W Niessen Journal: Diabetes Care Date: 2002-03 Impact factor: 19.112
Authors: O Kenrik Duru; Robert B Gerzoff; Arleen F Brown; Andrew J Karter; Catherine Kim; David Kountz; K M Venkat Narayan; Stephen H Schneider; Chien-Wen Tseng; Beth Waitzfelder; Carol M Mangione Journal: J Gen Intern Med Date: 2008-05-02 Impact factor: 5.128
Authors: Kurt Kroenke; Tara W Strine; Robert L Spitzer; Janet B W Williams; Joyce T Berry; Ali H Mokdad Journal: J Affect Disord Date: 2008-08-27 Impact factor: 4.839
Authors: Susan J Andreae; Lynn J Andreae; Joshua S Richman; Andrea L Cherrington; Monika M Safford Journal: Ann Fam Med Date: 2020-01 Impact factor: 5.166
Authors: Susan J Andreae; Lynn J Andreae; Andrea L Cherrington; Marquita Lewis; Ethel Johnson; Debra Clark; Monika M Safford Journal: Fam Community Health Date: 2018 Jul-Sep
Authors: Thomas Rehling; Anne-Sofie Dam Bjørkman; Marie Borring Andersen; Ola Ekholm; Stig Molsted Journal: J Diabetes Res Date: 2019-12-06 Impact factor: 4.011