Jonathan J Noble1, Nicola R Fry2, Andrew P Lewis3, Stephen F Keevil4, Martin Gough2, Adam P Shortland2. 1. Division of Imaging Sciences and Biomedical Engineering, King's College London, The Rayne Institute, 4th Floor, Lambeth Wing, St. Thomas' Hospital, London SE1 7EH, United Kingdom. Electronic address: jonathan.noble@gstt.nhs.uk. 2. One Small Step Gait Laboratory, Guy's and St. Thomas' NHS Foundation Trust, Guy's Hospital, London SE1 9RT, United Kingdom. 3. Division of Imaging Sciences and Biomedical Engineering, King's College London, The Rayne Institute, 4th Floor, Lambeth Wing, St. Thomas' Hospital, London SE1 7EH, United Kingdom. 4. Department of Medical Physics, Guy's and St. Thomas' NHS Foundation Trust, The Rayne Institute, 4th Floor, Lambeth Wing, St. Thomas' Hospital, London SE1 7EH, United Kingdom.
Abstract
AIM: Muscle weakness is a feature of individuals with spastic cerebral palsy (SCP) but there are few reports in the literature of muscle volume in this group. This study compares muscle volumes in adolescents and young adults with SCP with those of their typically developing (TD) peers. DESIGN: Measurements of the volumes of nine major lower limb muscles in 19 independently ambulant subjects with SCP (mean age 14.2 years (sd 2.7), 11 male, GMFCS I (n=5); GMFCS II (n=14)), 19 TD subjects (mean age 16.5 years (sd 3.0), 11 male) were made using magnetic resonance imaging. RESULTS: Lower limb muscles were smaller in the SCP group (p≤0.023 in all muscles) than the TD group with the exception of the vastii (lateralis+intermedius; p=0.868) and gluteus maximus (p=0.056). Average muscle volume deficit was 27.9%. Muscle volume deficits were significantly greater for distal muscles than proximal muscles (p<0.001). CONCLUSIONS: Reduced muscle size in adolescence and the natural history of sarcopenia in adulthood may contribute to the early loss of mobility of adults with SCP.
AIM: Muscle weakness is a feature of individuals with spastic cerebral palsy (SCP) but there are few reports in the literature of muscle volume in this group. This study compares muscle volumes in adolescents and young adults with SCP with those of their typically developing (TD) peers. DESIGN: Measurements of the volumes of nine major lower limb muscles in 19 independently ambulant subjects with SCP (mean age 14.2 years (sd 2.7), 11 male, GMFCS I (n=5); GMFCS II (n=14)), 19 TD subjects (mean age 16.5 years (sd 3.0), 11 male) were made using magnetic resonance imaging. RESULTS: Lower limb muscles were smaller in the SCP group (p≤0.023 in all muscles) than the TD group with the exception of the vastii (lateralis+intermedius; p=0.868) and gluteus maximus (p=0.056). Average muscle volume deficit was 27.9%. Muscle volume deficits were significantly greater for distal muscles than proximal muscles (p<0.001). CONCLUSIONS: Reduced muscle size in adolescence and the natural history of sarcopenia in adulthood may contribute to the early loss of mobility of adults with SCP.
Authors: I Duran; F Schütz; S Hamacher; O Semler; C Stark; J Schulze; J Rittweger; E Schoenau Journal: Osteoporos Int Date: 2017-04-01 Impact factor: 4.507
Authors: Mark D Peterson; Peng Zhang; Heidi J Haapala; Stewart C Wang; Edward A Hurvitz Journal: Arch Phys Med Rehabil Date: 2015-07-02 Impact factor: 3.966
Authors: Jennifer M Ryan; Nicola Theis; Cherry Kilbride; Vasilios Baltzopoulos; Charlie Waugh; Adam Shortland; Grace Lavelle; Marika Noorkoiv; Wendy Levin; Thomas Korff Journal: BMJ Open Date: 2016-10-04 Impact factor: 2.692
Authors: Helga Haberfehlner; Richard T Jaspers; Erich Rutz; Jules G Becher; Jaap Harlaar; Johannes A van der Sluijs; Melinda M Witbreuk; Jacqueline Romkes; Marie Freslier; Reinald Brunner; Huub Maas; Annemieke I Buizer Journal: PLoS One Date: 2016-11-18 Impact factor: 3.240
Authors: Jonathan J Noble; Geoffrey D Charles-Edwards; Stephen F Keevil; Andrew P Lewis; Martin Gough; Adam P Shortland Journal: BMC Musculoskelet Disord Date: 2014-07-12 Impact factor: 2.362