Literature DB >> 23790189

Association of IL-10 and CCL5 single nucleotide polymorphisms with tuberculosis in the Sudanese population.

Najwa Mhmoud1, Ahmed Fahal1, W J Wendy van de Sande2.   

Abstract

OBJECTIVE: To investigate the genetic determinants for developing tuberculosis in Sudan.
METHODS: Case study of 232 patients with tuberculosis and 206 healthy matched controls from Sudan. In the study population, three single nucleotide polymorphisms (SNPs) in the promoter regions of CCL5 and two in the promoter region of IL-10 were genotyped using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). These five SNPs influence the expression of these genes.
RESULTS: There were significant differences in allele distribution for CCL5 -28 C/G (rs 2280788) and IL-10 -592 A/C (rs1800872) in patients with tuberculosis compared with healthy controls.
CONCLUSION: This indicates that the genotypes obtained for CCL5 and IL-10 are associated with an increased risk of developing active TB.
© 2013 John Wiley & Sons Ltd.

Entities:  

Keywords:  PCR-RFLP; TB; mycobacterium; susceptibility

Mesh：

Substances：

Year:  2013        PMID： 23790189     DOI： 10.1111/tmi.12141

Source DB:  PubMed          Journal:  Trop Med Int Health        ISSN： 1360-2276            Impact factor:   2.622


  8 in total

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7.  A genetic association study of CCL5 -28 C>G (rs2280788) polymorphism with risk of tuberculosis: a meta-analysis.

Authors:  Mohammed A A Alqumber; Raju K Mandal; Shafiul Haque; Aditya K Panda; Naseem Akhter; Arif Ali
Journal:  PLoS One       Date:  2013-12-23       Impact factor: 3.240

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