Literature DB >> 2378789

Inter- and intrasubject variability of gastric emptying in healthy volunteers measured by scintigraphy and paracetamol absorption.

O U Petring1, H Flachs.   

Abstract

1. Inter- and intrasubject variability in the gastric emptying of semisolids and liquids was measured by scintigraphic emptying of radionuclide-labelled semisolid and from paracetamol absorption in ten healthy volunteers of both sexes. 2. The intrasubject variability was not statistically significant for any of scintigraphic or paracetamol absorption parameters. 3. The intersubject variation was significant for all scintigraphic and paracetamol absorption parameters. 4. In women, the gastric emptying rate of semisolid decreased linearly during the menstrual cycle. 5. The lag period and paracetamol absorption parameters were unrelated to the day of the menstrual cycle day. 6. There was no statistically significant relationship between scintigraphic and paracetamol absorption parameters.

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Year:  1990        PMID: 2378789      PMCID: PMC1380172          DOI: 10.1111/j.1365-2125.1990.tb03691.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN: 0306-5251            Impact factor:   4.335


  17 in total

1.  Influence of gender and menopause on gastric emptying and motility.

Authors:  W R Hutson; R L Roehrkasse; A Wald
Journal:  Gastroenterology       Date:  1989-01       Impact factor: 22.682

2.  The effect of phentolamine on basal and pethidine-induced inhibition of gastric emptying in healthy volunteers.

Authors:  O U Petring
Journal:  Br J Clin Pharmacol       Date:  1989-10       Impact factor: 4.335

3.  Proximal, distal and total stomach emptying of a digestible solid meal in normal subjects.

Authors:  P J Collins; M Horowitz; B E Chatterton
Journal:  Br J Radiol       Date:  1988-01       Impact factor: 3.039

4.  Gastric emptying rate measurement in man. A double isotope scanning technique for simultaneous study of liquid and solid components of a meal.

Authors:  R C Heading; P Tothill; G P McLoughlin; D J Shearman
Journal:  Gastroenterology       Date:  1976-07       Impact factor: 22.682

5.  Left anterior oblique projection and peak-to-scatter ratio for attenuation compensation of gastric emptying studies.

Authors:  F H Fahey; H A Ziessman; M J Collen; D F Eggli
Journal:  J Nucl Med       Date:  1989-02       Impact factor: 10.057

6.  Variability of gastric emptying measurements in man employing standardized radiolabeled meals.

Authors:  C M Brophy; J G Moore; P E Christian; M J Egger; A T Taylor
Journal:  Dig Dis Sci       Date:  1986-08       Impact factor: 3.199

7.  Effect of the menstrual cycle on gastric emptying.

Authors:  R C Gill; P D Murphy; H R Hooper; K L Bowes; Y J Kingma
Journal:  Digestion       Date:  1987       Impact factor: 3.216

8.  The relationship between gastric emptying of semisolids and paracetamol absorption.

Authors:  O U Petring; B Adelhøj; M Ibsen; H E Poulsen
Journal:  Br J Clin Pharmacol       Date:  1986-12       Impact factor: 4.335

9.  Kinetics of acetaminophen absorption and gastric emptying in man.

Authors:  J A Clements; R C Heading; W S Nimmo; L F Prescott
Journal:  Clin Pharmacol Ther       Date:  1978-10       Impact factor: 6.875

10.  Gender-related differences in gastric emptying.

Authors:  F L Datz; P E Christian; J Moore
Journal:  J Nucl Med       Date:  1987-07       Impact factor: 10.057

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  10 in total

Review 1.  How useful is paracetamol absorption as a marker of gastric emptying? A systematic literature study.

Authors:  M Willems; A O Quartero; M E Numans
Journal:  Dig Dis Sci       Date:  2001-10       Impact factor: 3.199

2.  Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects.

Authors:  A J Coupe; S S Davis; I R Wilding
Journal:  Pharm Res       Date:  1991-03       Impact factor: 4.200

3.  Gastric emptying and acetaminophen: lessons learnt from the several co-administered drugs on the experimental design.

Authors:  Nuggehally R Srinivas
Journal:  Eur J Clin Pharmacol       Date:  2015-09-08       Impact factor: 2.953

4.  The effect of octreotide on gastric emptying at a dosage used to prevent complications after pancreatic surgery: a randomised, placebo controlled study in volunteers.

Authors:  M I van Berge Henegouwen; T M van Gulik; L M Akkermans; J B Jansen; D J Gouma
Journal:  Gut       Date:  1997-12       Impact factor: 23.059

5.  Impaired gastric emptying in mechanically ventilated, critically ill patients.

Authors:  D K Heyland; G Tougas; D King; D J Cook
Journal:  Intensive Care Med       Date:  1996-12       Impact factor: 17.440

6.  Determinants of symptom pattern in idiopathic severely delayed gastric emptying: gastric emptying rate or proximal stomach dysfunction?

Authors:  G Karamanolis; P Caenepeel; J Arts; J Tack
Journal:  Gut       Date:  2006-07-13       Impact factor: 23.059

7.  Voluntary suppression of defecation delays gastric emptying.

Authors:  H C Tjeerdsma; A J Smout; L M Akkermans
Journal:  Dig Dis Sci       Date:  1993-05       Impact factor: 3.199

Review 8.  Pharmacokinetic considerations in gastrointestinal motor disorders.

Authors:  G S Hebbard; W M Sun; F Bochner; M Horowitz
Journal:  Clin Pharmacokinet       Date:  1995-01       Impact factor: 6.447

9.  Between-subject and within-subject variations in the pharmacokinetics of ethanol.

Authors:  A W Jones; K A Jönsson
Journal:  Br J Clin Pharmacol       Date:  1994-05       Impact factor: 4.335

10.  Simulation of the pharmacokinetics of bisoprolol in healthy adults and patients with impaired renal function using whole-body physiologically based pharmacokinetic modeling.

Authors:  Guo-fu Li; Kun Wang; Rui Chen; Hao-ru Zhao; Jin Yang; Qing-shan Zheng
Journal:  Acta Pharmacol Sin       Date:  2012-10-22       Impact factor: 6.150

  10 in total

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