BACKGROUND: This prospective study evaluated swallowing outcomes prechemoradiotherapy (pre-CRT) up to 1 year post-CRT, in a substantial cohort of patients with head and neck cancer and explored factors predicting outcome. METHODS: One hundred twelve patients were assessed pretreatment and at 3, 6, and 12 months posttreatment using a questionnaire, endoscopic assessment, water swallow test, and diet score. RESULTS: Seventy-one patients were retained, the majority had oropharyngeal (53%) or hypopharyngeal cancer (20%). A marked deterioration occurred between pretreatment and 3 months posttreatment (p ≤ .01). Significant improvement between 3 and 12 months was found on 2 swallowing measures, but not self reported. Three of the 4 pretreatment assessments predicted outcomes at 1 year. CONCLUSION: CRT results in a marked deterioration on different paradigms of swallowing measurements. Improvement occurs on some clinical measures, but limited change is observed in patients' perceptions. Pretreatment measures are important indicators of long-term dysphagia. Swallowing recovery is complex, taking different courses between clinical tests and perspectives.
BACKGROUND: This prospective study evaluated swallowing outcomes prechemoradiotherapy (pre-CRT) up to 1 year post-CRT, in a substantial cohort of patients with head and neck cancer and explored factors predicting outcome. METHODS: One hundred twelve patients were assessed pretreatment and at 3, 6, and 12 months posttreatment using a questionnaire, endoscopic assessment, water swallow test, and diet score. RESULTS: Seventy-one patients were retained, the majority had oropharyngeal (53%) or hypopharyngeal cancer (20%). A marked deterioration occurred between pretreatment and 3 months posttreatment (p ≤ .01). Significant improvement between 3 and 12 months was found on 2 swallowing measures, but not self reported. Three of the 4 pretreatment assessments predicted outcomes at 1 year. CONCLUSION: CRT results in a marked deterioration on different paradigms of swallowing measurements. Improvement occurs on some clinical measures, but limited change is observed in patients' perceptions. Pretreatment measures are important indicators of long-term dysphagia. Swallowing recovery is complex, taking different courses between clinical tests and perspectives.
Authors: Isabela Porto de Toledo; Leticia Lopes Quirino Pantoja; Karen Fontes Luchesi; Daniele Xavier Assad; Graziela De Luca Canto; Eliete Neves Silva Guerra Journal: Support Care Cancer Date: 2019-06-22 Impact factor: 3.603
Authors: Molly K Barnhart; Bena Cartmill; Elizabeth C Ward; Elizabeth Brown; Jonathon Sim; George Saade; Sandra Rayner; Rachelle A Robinson; Virginia A Simms; Robert I Smee Journal: Dysphagia Date: 2019-02-11 Impact factor: 3.438
Authors: Molly K Barnhart; Elizabeth C Ward; Bena Cartmill; Rachelle A Robinson; Virginia A Simms; Sophie J Chandler; Elea T Wurth; Robert I Smee Journal: Eur Arch Otorhinolaryngol Date: 2016-08-06 Impact factor: 2.503
Authors: Ryan P Goepfert; Jan S Lewin; Martha P Barrow; G Brandon Gunn; C David Fuller; Beth M Beadle; Adam S Garden; David I Rosenthal; Merrill S Kies; Vassiliki Papadimitrakopoulou; Stephen Y Lai; Neil D Gross; David L Schwartz; Katherine A Hutcheson Journal: Int J Radiat Oncol Biol Phys Date: 2016-06-15 Impact factor: 7.038
Authors: Alana Aylward; Sarah Abdelaziz; Jason P Hunt; Luke O Buchmann; Richard B Cannon; Shane Lloyd; Ying Hitchcock; Mia Hashibe; Marcus M Monroe Journal: Otolaryngol Head Neck Surg Date: 2019-06-11 Impact factor: 3.497
Authors: Ryan P Goepfert; Jan S Lewin; Martha P Barrow; Carla L Warneke; Clifton D Fuller; Stephen Y Lai; Randal S Weber; Katherine A Hutcheson Journal: Dysphagia Date: 2017-08-23 Impact factor: 3.438