S-F Chen1, T-M Hu2, T-H Lan3, H-J Chiu4, L-Y Sheen5, E-W Loh6. 1. Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan. 2. Yu-Li Veterans Hospital, Yu-Li Town, Hualian County, Taiwan. 3. Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan; Faculty of Medicine, National Yang Ming University, Taipei, Taiwan; Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan. 4. Faculty of Medicine, National Yang Ming University, Taipei, Taiwan; Chung Hwa University of Medical Technology, Tainan, Taiwan; Jianan Mental Hospital, Tainan, Taiwan. 5. Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan. Electronic address: lysheen@ntu.edu.tw. 6. Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan; Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung, Taiwan. Electronic address: lohelwui@yahoo.com.tw.
Abstract
BACKGROUND: Metabolic abnormality is common among schizophrenia patients. Some metabolic traits were found associated with subgroups of schizophrenia patients. OBJECTIVES: We examined a possible relationship between metabolic abnormality and psychosis profile in schizophrenia patients. METHOD: Three hundred and seventy-two chronic schizophrenia patients treated with antipsychotics for more than 2 years were assessed with the Positive and Negative Syndrome Scale. A set of metabolic traits was measured at scheduled checkpoints between October 2004 and September 2006. RESULTS: Multiple regressions adjusted for sex showed negative correlations between body mass index (BMI) and total score and all subscales; triglycerides (TG) was negatively correlated with total score and negative syndrome, while HDLC was positively correlated with negative syndrome. When sex interaction was concerned, total score was negatively correlated with BMI but not with others; negative syndrome was negatively correlated with BMI and positively with HDLC. No metabolic traits were correlated with positive syndrome or general psychopathology. CONCLUSIONS: Loss of body weight is a serious health problem in schizophrenia patients with severe psychosis syndrome, especially the negative syndrome. Schizophrenia patients with severe negative syndrome may have a distinct lipid pathophysiology in comparison with those who were less severe in the domain.
BACKGROUND:Metabolic abnormality is common among schizophreniapatients. Some metabolic traits were found associated with subgroups of schizophreniapatients. OBJECTIVES: We examined a possible relationship between metabolic abnormality and psychosis profile in schizophreniapatients. METHOD: Three hundred and seventy-two chronic schizophreniapatients treated with antipsychotics for more than 2 years were assessed with the Positive and Negative Syndrome Scale. A set of metabolic traits was measured at scheduled checkpoints between October 2004 and September 2006. RESULTS: Multiple regressions adjusted for sex showed negative correlations between body mass index (BMI) and total score and all subscales; triglycerides (TG) was negatively correlated with total score and negative syndrome, while HDLC was positively correlated with negative syndrome. When sex interaction was concerned, total score was negatively correlated with BMI but not with others; negative syndrome was negatively correlated with BMI and positively with HDLC. No metabolic traits were correlated with positive syndrome or general psychopathology. CONCLUSIONS: Loss of body weight is a serious health problem in schizophreniapatients with severe psychosis syndrome, especially the negative syndrome. Schizophreniapatients with severe negative syndrome may have a distinct lipid pathophysiology in comparison with those who were less severe in the domain.
Authors: Virawudh Soontornniyomkij; Ellen E Lee; Hua Jin; Averria Sirkin Martin; Rebecca E Daly; Jinyuan Liu; Xin M Tu; Lisa Todd Eyler; Dilip V Jeste Journal: Front Psychiatry Date: 2019-04-23 Impact factor: 4.157
Authors: Elena G Kornetova; Alexander N Kornetov; Irina A Mednova; Anastasia A Goncharova; Valeria I Gerasimova; Ivan V Pozhidaev; Anastasiia S Boiko; Arkadiy V Semke; Anton J M Loonen; Nikolay A Bokhan; Svetlana A Ivanova Journal: Front Psychiatry Date: 2021-07-02 Impact factor: 4.157