Literature DB >> 23765287

¹H, ¹³C and ¹⁵N NMR assignments of a Drosophila Hedgehog autoprocessing domain.

Jian Xie1, Zhenming Du, Brian Callahan, Marlene Belfort, Chunyu Wang.   

Abstract

The Hedgehog (Hh) signaling pathway plays important roles in embryonic growth and patterning in different organisms. Abnormal activity of the Hh signaling pathway has been associated to cancers, holoprosencephaly and autism spectrum disorders. The backbone and side chain resonance assignments of a Drosophila Hh autoprocessing domain have been determined based on triple-resonance experiments with the [(13)C, (15)N]-labeled and [(2)H, (13)C, (15)N])-labeled proteins.

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Year:  2013        PMID： 23765287      PMCID： PMC3884045          DOI： 10.1007/s12104-013-9500-8

Source DB:  PubMed          Journal:  Biomol NMR Assign        ISSN： 1874-270X            Impact factor:   0.746


  10 in total

Review 1.  Hedgehog: functions and mechanisms.

Authors:  Markku Varjosalo; Jussi Taipale
Journal:  Genes Dev       Date:  2008-09-15       Impact factor: 11.361

2.  Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain.

Authors:  J A Porter; S C Ekker; W J Park; D P von Kessler; K E Young; C H Chen; Y Ma; A S Woods; R J Cotter; E V Koonin; P A Beachy
Journal:  Cell       Date:  1996-07-12       Impact factor: 41.582

3.  Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins.

Authors:  T M Hall; J A Porter; K E Young; E V Koonin; P A Beachy; D J Leahy
Journal:  Cell       Date:  1997-10-03       Impact factor: 41.582

4.  pK(a) coupling at the intein active site: implications for the coordination mechanism of protein splicing with a conserved aspartate.

Authors:  Zhenming Du; Yuchuan Zheng; Melissa Patterson; Yangzhong Liu; Chunyu Wang
Journal:  J Am Chem Soc       Date:  2011-06-09       Impact factor: 15.419

5.  Branched intermediate formation stimulates peptide bond cleavage in protein splicing.

Authors:  Silvia Frutos; Michael Goger; Baldissera Giovani; David Cowburn; Tom W Muir
Journal:  Nat Chem Biol       Date:  2010-05-23       Impact factor: 15.040

6.  Cholesterol modification of hedgehog signaling proteins in animal development.

Authors:  J A Porter; K E Young; P A Beachy
Journal:  Science       Date:  1996-10-11       Impact factor: 47.728

7.  Highly conserved histidine plays a dual catalytic role in protein splicing: a pKa shift mechanism.

Authors:  Zhenming Du; Philip T Shemella; Yangzhong Liu; Scott A McCallum; Brian Pereira; Saroj K Nayak; Georges Belfort; Marlene Belfort; Chunyu Wang
Journal:  J Am Chem Soc       Date:  2009-08-19       Impact factor: 15.419

8.  NMR and crystal structures of the Pyrococcus horikoshii RadA intein guide a strategy for engineering a highly efficient and promiscuous intein.

Authors:  Jesper S Oeemig; Dongwen Zhou; Tommi Kajander; Alexander Wlodawer; Hideo Iwaï
Journal:  J Mol Biol       Date:  2012-05-02       Impact factor: 5.469

9.  Processing and turnover of the Hedgehog protein in the endoplasmic reticulum.

Authors:  Xin Chen; Hanna Tukachinsky; Chih-Hsiang Huang; Cindy Jao; Yue-Ru Chu; Hsiang-Yun Tang; Britta Mueller; Sol Schulman; Tom A Rapoport; Adrian Salic
Journal:  J Cell Biol       Date:  2011-02-28       Impact factor: 10.539

10.  Relationship between Sonic hedgehog protein, brain-derived neurotrophic factor and oxidative stress in autism spectrum disorders.

Authors:  Laila Y Al-Ayadhi
Journal:  Neurochem Res       Date:  2011-10-09       Impact factor: 3.996
  10 in total
  5 in total

Review 1.  Thiol-based redox switches.

Authors:  Bastian Groitl; Ursula Jakob
Journal:  Biochim Biophys Acta       Date:  2014-03-19

2.  Zinc inhibits Hedgehog autoprocessing: linking zinc deficiency with Hedgehog activation.

Authors:  Jian Xie; Timothy Owen; Ke Xia; Ajay Vikram Singh; Emiley Tou; Lingyun Li; Brigitte Arduini; Hongmin Li; Leo Q Wan; Brian Callahan; Chunyu Wang
Journal:  J Biol Chem       Date:  2015-03-18       Impact factor: 5.157

3.  Active site targeting of hedgehog precursor protein with phenylarsine oxide.

Authors:  Timothy S Owen; Xie Jian Xie; Benjamin Laraway; George Ngoje; Chunyu Wang; Brian P Callahan
Journal:  Chembiochem       Date:  2014-11-21       Impact factor: 3.164

Review 4.  Hedgehog Autoprocessing: From Structural Mechanisms to Drug Discovery.

Authors:  Nabin Kandel; Chunyu Wang
Journal:  Front Mol Biosci       Date:  2022-05-20

5.  Nanomolar, Noncovalent Antagonism of Hedgehog Cholesterolysis: Exception to the "Irreversibility Rule" for Protein Autoprocessing Inhibition.

Authors:  Andrew G Wagner; Robert T Stagnitta; Zihan Xu; John L Pezzullo; Nabin Kandel; José-Luis Giner; Douglas F Covey; Chunyu Wang; Brian P Callahan
Journal:  Biochemistry       Date:  2021-12-23       Impact factor: 3.321
  5 in total

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