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Literature DB >> 23764256

Insights from natural host-parasite interactions: the Drosophila model.

Abstract

Immune responses against opportunistic pathogens have been extensively studied in Drosophila, leading to a detailed map of the genetics behind innate immunity networks including the Toll, Imd, Jak-Stat, and JNK pathways. However, immune mechanisms of other organisms, such as plants, have primarily been investigated using natural pathogens. It was the use of natural pathogens in plant research that revealed the plant R-Avr system, a specialized immune response derived from antagonistic coevolution between plant immune proteins and their natural pathogens' virulence proteins. Thus, we recommend that researchers begin to use natural Drosophila pathogens to identify novel immune strategies that may have arisen through antagonistic coevolution with common natural pathogens. In this review, we address the benefits of using natural pathogens in research, describe the known natural pathogens of Drosophila, and discuss the future prospects for research on natural pathogens of Drosophila.

Entities: Chemical Disease Gene Species

Keywords: Coevolution; Drosophila immunity; Natural pathogens

Mesh：

Substances：

Year: 2013 PMID： 23764256 PMCID： PMC3808516 DOI： 10.1016/j.dci.2013.06.001

Source DB: PubMed Journal: Dev Comp Immunol ISSN： 0145-305X Impact factor: 3.636

155 in total

1. Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila.

Authors: Delphine Galiana-Arnoux; Catherine Dostert; Anette Schneemann; Jules A Hoffmann; Jean-Luc Imler
Journal: Nat Immunol Date: 2006-03-23 Impact factor: 25.606

Review 2. Animal models of human respiratory syncytial virus disease.

Authors: Reinout A Bem; Joseph B Domachowske; Helene F Rosenberg
Journal: Am J Physiol Lung Cell Mol Physiol Date: 2011-05-13 Impact factor: 5.464

3. Arms races between and within species.

Authors: R Dawkins; J R Krebs
Journal: Proc R Soc Lond B Biol Sci Date: 1979-09-21

Review 4. Systems biology of natural simian immunodeficiency virus infections.

Authors: Steven E Bosinger; Béatrice Jacquelin; Arndt Benecke; Guido Silvestri; Michaela Müller-Trutwin
Journal: Curr Opin HIV AIDS Date: 2012-01 Impact factor: 4.283

5. Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila.

Authors: Nicolas Vodovar; David Vallenet; Stéphane Cruveiller; Zoé Rouy; Valérie Barbe; Carlos Acosta; Laurence Cattolico; Claire Jubin; Aurélie Lajus; Béatrice Segurens; Benoît Vacherie; Patrick Wincker; Jean Weissenbach; Bruno Lemaitre; Claudine Médigue; Frédéric Boccard
Journal: Nat Biotechnol Date: 2006-05-14 Impact factor: 54.908

6. Broad RNA interference-mediated antiviral immunity and virus-specific inducible responses in Drosophila.

Authors: Cordula Kemp; Stefanie Mueller; Akira Goto; Vincent Barbier; Simona Paro; François Bonnay; Catherine Dostert; Laurent Troxler; Charles Hetru; Carine Meignin; Sébastien Pfeffer; Jules A Hoffmann; Jean-Luc Imler
Journal: J Immunol Date: 2012-12-19 Impact factor: 5.422

7. Protozoan and intracellular fungal gut endosymbionts in Drosophila: prevalence and fitness effects of single and dual infections.

Authors: Mercedes A Ebbert; Jennifer L Marlowe; Jennifer J Burkholder
Journal: J Invertebr Pathol Date: 2003-05 Impact factor: 2.841

8. Yeast communities of diverse Drosophila species: comparison of two symbiont groups in the same hosts.

Authors: James Angus Chandler; Jonathan A Eisen; Artyom Kopp
Journal: Appl Environ Microbiol Date: 2012-08-10 Impact factor: 4.792

9. Innate immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in Drosophila.

Authors: Ji-Hwan Ryu; Sung-Hee Kim; Hyo-Young Lee; Jin Young Bai; Young-Do Nam; Jin-Woo Bae; Dong Gun Lee; Seung Chul Shin; Eun-Mi Ha; Won-Jae Lee
Journal: Science Date: 2008-01-24 Impact factor: 47.728

10. Monalysin, a novel ß-pore-forming toxin from the Drosophila pathogen Pseudomonas entomophila, contributes to host intestinal damage and lethality.

Authors: Onya Opota; Isabelle Vallet-Gély; Renaud Vincentelli; Christine Kellenberger; Ioan Iacovache; Manuel Rodrigo Gonzalez; Alain Roussel; Françoise-Gisou van der Goot; Bruno Lemaitre
Journal: PLoS Pathog Date: 2011-09-29 Impact factor: 6.823

29 in total

Insights from natural host-parasite interactions: the Drosophila model.

1. Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila.

Review 2. Animal models of human respiratory syncytial virus disease.

3. Arms races between and within species.

Review 4. Systems biology of natural simian immunodeficiency virus infections.

5. Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila.

6. Broad RNA interference-mediated antiviral immunity and virus-specific inducible responses in Drosophila.

7. Protozoan and intracellular fungal gut endosymbionts in Drosophila: prevalence and fitness effects of single and dual infections.

8. Yeast communities of diverse Drosophila species: comparison of two symbiont groups in the same hosts.

9. Innate immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in Drosophila.

10. Monalysin, a novel ß-pore-forming toxin from the Drosophila pathogen Pseudomonas entomophila, contributes to host intestinal damage and lethality.

1. Harnessing the natural Drosophila-parasitoid model for integrating insect immunity with functional venomics.

Review 2. Arthropod Innate Immune Systems and Vector-Borne Diseases.

3. Drosophila innate immunity: regional and functional specialization of prophenoloxidases.

Review 4. Studying the immune response to human viral infections using zebrafish.

5. Parasitoid wasp virulence: A window into fly immunity.

6. A Model for Evolutionary Ecology of Disease: The Case for Caenorhabditis Nematodes and Their Natural Parasites.

Review 7. The secret lives of Drosophila flies.

8. Systemic bacterial infection and immune defense phenotypes in Drosophila melanogaster.

9. A parasitoid wasp of Drosophila employs preemptive and reactive strategies to deplete its host's blood cells.

Review 10. Drosophila as a Model for Infectious Diseases.