Literature DB >> 23759879

Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Fourth Meeting: lessons learned from first clinical trials.

Marcella Franquesa1, Martin J Hoogduijn, Marlies E Reinders, Elke Eggenhofer, Anja U Engela, Fane K Mensah, Joan Torras, Antonello Pileggi, Cees van Kooten, Bernard Mahon, Oliver Detry, Felix C Popp, Volker Benseler, Federica Casiraghi, Christian Johnson, Janis Ancans, Barbara Fillenberg, Olga delaRosa, Josep M Aran, Marieke Roemeling-van Rhijn, Marieke Roemeling-vanRhijn, Jef Pinxteren, Norberto Perico, Eliana Gotti, Bruno Christ, James Reading, Martino Introna, Robert Deans, Murat Shagidulin, Ramon Farré, Alessandro Rambaldi, Albert Sanchez-Fueyo, Natasha Obermajer, Andrey Pulin, Frank J M F Dor, Isabel Portero-Sanchez, Carla C Baan, Ton J Rabelink, Giuseppe Remuzzi, Michiel G H Betjes, Marc H Dahlke, Josep M Grinyó.   

Abstract

The Fourth Expert Meeting of the Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Consortium took place in Barcelona on October 19 and 20, 2012. This meeting focused on the translation of preclinical data into early clinical settings. This position paper highlights the main topics explored on the safety and efficacy of mesenchymal stem cells as a therapeutic agent in solid organ transplantation and emphasizes the issues (proper timing, concomitant immunossupression, source and immunogenicity of mesenchymal stem cells, and oncogenicity) that have been addressed and will be followed up by the MiSOT Consortium in future studies.

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Year:  2013        PMID: 23759879      PMCID: PMC3737392          DOI: 10.1097/TP.0b013e318298f9fa

Source DB:  PubMed          Journal:  Transplantation        ISSN: 0041-1337            Impact factor:   4.939


  17 in total

1.  Mesenchymal stem cells derived from adipose tissue are not affected by renal disease.

Authors:  Marieke Roemeling-van Rhijn; Marlies E J Reinders; Annelies de Klein; Hannie Douben; Sander S Korevaar; Fane K F Mensah; Frank J M F Dor; Jan N M IJzermans; Michiel G H Betjes; Carla C Baan; Willem Weimar; Martin J Hoogduijn
Journal:  Kidney Int       Date:  2012-06-13       Impact factor: 10.612

2.  Cell biology. To scientists' dismay, mixed-up cell lines strike again.

Authors:  Gretchen Vogel
Journal:  Science       Date:  2010-08-27       Impact factor: 47.728

3.  Safety and feasibility of third-party multipotent adult progenitor cells for immunomodulation therapy after liver transplantation--a phase I study (MISOT-I).

Authors:  Felix C Popp; Barbara Fillenberg; Elke Eggenhofer; Philipp Renner; Johannes Dillmann; Volker Benseler; Andreas A Schnitzbauer; James Hutchinson; Robert Deans; Deborah Ladenheim; Cheryl A Graveen; Florian Zeman; Michael Koller; Martin J Hoogduijn; Edward K Geissler; Hans J Schlitt; Marc H Dahlke
Journal:  J Transl Med       Date:  2011-07-28       Impact factor: 5.531

4.  Autologous mesenchymal stromal cells and kidney transplantation: a pilot study of safety and clinical feasibility.

Authors:  Norberto Perico; Federica Casiraghi; Martino Introna; Eliana Gotti; Marta Todeschini; Regiane Aparecida Cavinato; Chiara Capelli; Alessandro Rambaldi; Paola Cassis; Paola Rizzo; Monica Cortinovis; Maddalena Marasà; Josee Golay; Marina Noris; Giuseppe Remuzzi
Journal:  Clin J Am Soc Nephrol       Date:  2010-10-07       Impact factor: 8.237

5.  Autologous bone marrow-derived mesenchymal stromal cells for the treatment of allograft rejection after renal transplantation: results of a phase I study.

Authors:  Marlies E J Reinders; Johan W de Fijter; Helene Roelofs; Ingeborg M Bajema; Dorottya K de Vries; Alexander F Schaapherder; Frans H J Claas; Paula P M C van Miert; Dave L Roelen; Cees van Kooten; Willem E Fibbe; Ton J Rabelink
Journal:  Stem Cells Transl Med       Date:  2013-01-24       Impact factor: 6.940

6.  Donor-derived mesenchymal stem cells combined with low-dose tacrolimus prevent acute rejection after renal transplantation: a clinical pilot study.

Authors:  Yanwen Peng; Ming Ke; Lu Xu; Longshan Liu; Xiaoyong Chen; Wenjie Xia; Xiaobo Li; Zhen Chen; Junjie Ma; Dehuai Liao; Guanghui Li; Jiali Fang; Guanghui Pan; Andy Peng Xiang
Journal:  Transplantation       Date:  2013-01-15       Impact factor: 4.939

Review 7.  Mesenchymal stromal cells: a key player in 'innate tolerance'?

Authors:  Francesco Dazzi; Luciene Lopes; Ling Weng
Journal:  Immunology       Date:  2012-11       Impact factor: 7.397

Review 8.  Multipotent mesenchymal stromal cell therapy and risk of malignancies.

Authors:  Federica Casiraghi; Giuseppe Remuzzi; Mauro Abbate; Norberto Perico
Journal:  Stem Cell Rev Rep       Date:  2013-02       Impact factor: 5.739

9.  Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion.

Authors:  E Eggenhofer; V Benseler; A Kroemer; F C Popp; E K Geissler; H J Schlitt; C C Baan; M H Dahlke; M J Hoogduijn
Journal:  Front Immunol       Date:  2012-09-26       Impact factor: 7.561

10.  Cell therapy medicinal product regulatory framework in Europe and its application for MSC-based therapy development.

Authors:  Janis Ancans
Journal:  Front Immunol       Date:  2012-08-14       Impact factor: 7.561

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  19 in total

1.  Bone marrow mesenchymal stromal cells drive protective M2 microglia polarization after brain trauma.

Authors:  Elisa R Zanier; Francesca Pischiutta; Loredana Riganti; Federica Marchesi; Elena Turola; Stefano Fumagalli; Carlo Perego; Emanuela Parotto; Paola Vinci; Pietro Veglianese; Giovanna D'Amico; Claudia Verderio; Maria-Grazia De Simoni
Journal:  Neurotherapeutics       Date:  2014-07       Impact factor: 7.620

Review 2.  Mesenchymal stromal (stem) cells to improve solid organ transplant outcome: lessons from the initial clinical trials.

Authors:  Antonello Pileggi; Xiumin Xu; Jianming Tan; Camillo Ricordi
Journal:  Curr Opin Organ Transplant       Date:  2013-12       Impact factor: 2.640

3.  Morphology and size of stem cells from mouse and whale: observational study.

Authors:  Martin J Hoogduijn; Johanna C van den Beukel; Lidewij C M Wiersma; Jooske Ijzer
Journal:  BMJ       Date:  2013-12-12

Review 4.  Ex Vivo Mesenchymal Stem Cell Therapy to Regenerate Machine Perfused Organs.

Authors:  Christina Bogensperger; Julia Hofmann; Franka Messner; Thomas Resch; Andras Meszaros; Benno Cardini; Annemarie Weissenbacher; Rupert Oberhuber; Jakob Troppmair; Dietmar Öfner; Stefan Schneeberger; Theresa Hautz
Journal:  Int J Mol Sci       Date:  2021-05-15       Impact factor: 5.923

Review 5.  Large Animal Models of Vascularized Composite Allotransplantation: A Review of Immune Strategies to Improve Allograft Outcomes.

Authors:  Abraham J Matar; Rebecca L Crepeau; Gerhard S Mundinger; Curtis L Cetrulo; Radbeh Torabi
Journal:  Front Immunol       Date:  2021-06-30       Impact factor: 7.561

Review 6.  Safety and Efficacy Endpoints for Mesenchymal Stromal Cell Therapy in Renal Transplant Recipients.

Authors:  J R Bank; T J Rabelink; J W de Fijter; M E J Reinders
Journal:  J Immunol Res       Date:  2015-07-15       Impact factor: 4.818

7.  Safety of allogeneic bone marrow derived mesenchymal stromal cell therapy in renal transplant recipients: the neptune study.

Authors:  Marlies E J Reinders; Geertje J Dreyer; Jonna R Bank; Helene Roelofs; Sebastiaan Heidt; Dave L Roelen; Maarten L Zandvliet; Volkert A L Huurman; Wim E Fibbe; Cees van Kooten; Frans H J Claas; Ton J Rabelink; Johan W de Fijter
Journal:  J Transl Med       Date:  2015-11-04       Impact factor: 5.531

8.  Development of a Functional Biomarker for Use in Cell-Based Therapy Studies in Seropositive Rheumatoid Arthritis.

Authors:  Gali Shalev-Malul; David C Soler; Anthony E Ting; Nicholas A Lehman; Emma Barnboym; Thomas S McCormick; Donald D Anthony; Hillard M Lazarus; Arnold I Caplan; Maya Breitman; Nora G Singer
Journal:  Stem Cells Transl Med       Date:  2016-03-29       Impact factor: 6.940

Review 9.  Transplant Tolerance Induction in Newborn Infants: Mechanisms, Advantages, and Potential Strategies.

Authors:  Hua Pan; Aram Gazarian; Jean-Michel Dubernard; Alexandre Belot; Marie-Cécile Michallet; Mauricette Michallet
Journal:  Front Immunol       Date:  2016-04-07       Impact factor: 7.561

10.  Mesenchymal Stem Cells Enhance Nerve Regeneration in a Rat Sciatic Nerve Repair and Hindlimb Transplant Model.

Authors:  Damon S Cooney; Eric G Wimmers; Zuhaib Ibrahim; Johanna Grahammer; Joani M Christensen; Gabriel A Brat; Lehao W Wu; Karim A Sarhane; Joseph Lopez; Christoph Wallner; Georg J Furtmüller; Nance Yuan; John Pang; Kakali Sarkar; W P Andrew Lee; Gerald Brandacher
Journal:  Sci Rep       Date:  2016-08-11       Impact factor: 4.379

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