| Literature DB >> 23759245 |
Qitian Mu1, Yungui Wang, Bing Chen, Wenbin Qian, Haitao Meng, Hongyan Tong, Feifei Chen, Qiuling Ma, Wanmao Ni, Saijuan Chen, Jie Jin.
Abstract
Musashi-2 (MSI2) expression of 116 adult B-cells acute lymphoblastic leukemia (B-ALL) patients was measured by real-time PCR. Kaplan-Meier analysis showed that patients with high MSI2 expression had inferior overall survival (OS) (P=0.004), event free survival (EFS) (P=0.001) and relapse free survival (RFS) (P=0.018) in BCR-ABL-negative B-ALL. Multivariate models revealed that, besides WBC more than 30×10(9)/L and IK6 variant of IKZF1, high MSI2 expression was also an independent prognostic factor for adult BCR-ABL-negative B-ALL. Our data suggest that high MSI2 expression could indicate poor prognosis and facilitate risk and treatment stratification in adult BCR-ABL-negative B-ALL.Entities:
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Year: 2013 PMID： 23759245 DOI： 10.1016/j.leukres.2013.05.012
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156