Literature DB >> 23757374

A controlled-release nanocarrier with extracellular pH value driven tumor targeting and translocation for drug delivery.

Zilong Zhao1, Hongmin Meng, Nannan Wang, Michael J Donovan, Ting Fu, Mingxu You, Zhuo Chen, Xiaobing Zhang, Weihong Tan.   

Abstract

This pHLIP is no flop: Functionalizing mesoporous silica nanoparticles (MSNs) with pHLIPss peptide provides a controlled-release nanoparticle drug delivery system targeting the acidic tumor microenvironment. At low pH values, pHLIPss inserts into the cell membrane and translocates carriers into cells, where the cargo is released by the cleavage of the pHLIPss disulfide bonds (see scheme).
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  drug delivery; mesoporous silica nanoparticle; nanocarriers; pHLIP; targeted release

Mesh：

Substances：

Year:  2013        PMID： 23757374     DOI： 10.1002/anie.201302557

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  31 in total

1.  Enhancement of radiation effect on cancer cells by gold-pHLIP.

Authors:  Michael P Antosh; Dayanjali D Wijesinghe; Samana Shrestha; Robert Lanou; Yun Hu Huang; Thomas Hasselbacher; David Fox; Nicola Neretti; Shouheng Sun; Natallia Katenka; Leon N Cooper; Oleg A Andreev; Yana K Reshetnyak
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-13       Impact factor: 11.205

Review 2.  Extracellularly activatable nanocarriers for drug delivery to tumors.

Authors:  Sara A Abouelmagd; Hyesun Hyun; Yoon Yeo
Journal:  Expert Opin Drug Deliv       Date:  2014-06-20       Impact factor: 6.648

3.  A pH-dependent charge reversal peptide for cancer targeting.

Authors:  Naoko Wakabayashi; Yoshiaki Yano; Kenichi Kawano; Katsumi Matsuzaki
Journal:  Eur Biophys J       Date:  2016-06-08       Impact factor: 1.733

4.  pH-Dependent Cellular Internalization of Paramagnetic Nanoparticle.

Authors:  Branislava Janic; Mohammed Pi Bhuiyan; James R Ewing; Meser M Ali
Journal:  ACS Sens       Date:  2016-08-10       Impact factor: 7.711

5.  Advanced Functional Nanomaterials for Theranostics.

Authors:  Haoyuan Huang; Jonathan F Lovell
Journal:  Adv Funct Mater       Date:  2016-11-07       Impact factor: 18.808

6.  Noncanonical amino acids to improve the pH response of pHLIP insertion at tumor acidity.

Authors:  Joab O Onyango; Michael S Chung; Chee-Huat Eng; Lukas M Klees; Rachel Langenbacher; Lan Yao; Ming An
Journal:  Angew Chem Int Ed Engl       Date:  2015-02-04       Impact factor: 15.336

7.  Advanced targeted nanomedicine.

Authors:  Mohan C Pereira; Mohan C M Arachchige; Yana K Reshetnyak; Oleg A Andreev
Journal:  J Biotechnol       Date:  2015-01-20       Impact factor: 3.307

8.  Two-photon excited fluorescent silica nanoparticles loaded with iron(II) as a probe for determination and imaging of hydrogen peroxide in living cells.

Authors:  Di Zhao; Hongmin Meng; Ming-Qing Shi; Na Li; Guo-Jiang Mao
Journal:  Mikrochim Acta       Date:  2019-11-19       Impact factor: 5.833

9.  Functional nanovalves on protein-coated nanoparticles for in vitro and in vivo controlled drug delivery.

Authors:  Angela A Hwang; Jie Lu; Fuyuhiko Tamanoi; Jeffrey I Zink
Journal:  Small       Date:  2014-09-05       Impact factor: 13.281

Review 10.  Stimuli-responsive nanoparticles for targeting the tumor microenvironment.

Authors:  Jinzhi Du; Lucas A Lane; Shuming Nie
Journal:  J Control Release       Date:  2015-09-01       Impact factor: 9.776
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