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Literature DB >> 25615945

Advanced targeted nanomedicine.

Mohan C Pereira, Mohan C M Arachchige¹, Yana K Reshetnyak¹, Oleg A Andreev².

Abstract

Targeted drug delivery has been the major topic in drug formulation and delivery. As nanomedicine emerges to create nano scale therapeutics and diagnostics, it is still essential to embed targeting capability to these novel systems to make them useful. Here we discuss various targeting approaches for delivery of therapeutic and diagnostic nano materials in view of search for more universal methods to target diseased tissues. Many diseases are accompanied with hypoxia and acidosis. Coating nanoparticles with pH Low Insertion Peptides (pHLIPs) increases efficiency of targeting acidic diseased tissues. It has been showing promising results to create future nanotheranostics for cancer and other diseases which are dominating in the present world.

Entities: Chemical Disease Gene Species

Keywords: Active targeting; Environmental targeting; Nanomedicine; Passive targeting; Tissue acidity; pHLIP

Mesh：

Substances：

Year: 2015 PMID： 25615945 PMCID： PMC4685670 DOI： 10.1016/j.jbiotec.2015.01.009

Source DB: PubMed Journal: J Biotechnol ISSN： 0168-1656 Impact factor: 3.307

147 in total

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19 in total

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