Literature DB >> 23752927

ALDH2, a novel protector against stroke?

Aijun Sun1, Jun Ren.   

Abstract

In a recent paper published in Cell Research, an association between expression of mitochondrial aldehyde dehydrogenase (ALDH2), a mitochondrial chaperon expressed in the brain, and the prevalence of stroke is revealed. This finding indicates that ALDH2 may serve as a potential endogenous neuroprotective target and a promising therapeutic strategy for the management of stroke.

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Year:  2013        PMID： 23752927      PMCID： PMC3698642          DOI： 10.1038/cr.2013.76

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  12 in total

1.  Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.

Authors:  Norihiro Kato; Fumihiko Takeuchi; Yasuharu Tabara; Tanika N Kelly; Min Jin Go; Xueling Sim; Wan Ting Tay; Chien-Hsiun Chen; Yi Zhang; Ken Yamamoto; Tomohiro Katsuya; Mitsuhiro Yokota; Young Jin Kim; Rick Twee Hee Ong; Toru Nabika; Dongfeng Gu; Li-Ching Chang; Yoshihiro Kokubo; Wei Huang; Keizo Ohnaka; Yukio Yamori; Eitaro Nakashima; Cashell E Jaquish; Jong-Young Lee; Mark Seielstad; Masato Isono; James E Hixson; Yuan-Tsong Chen; Tetsuro Miki; Xueya Zhou; Takao Sugiyama; Jae-Pil Jeon; Jian Jun Liu; Ryoichi Takayanagi; Sung Soo Kim; Tin Aung; Yun Ju Sung; Xuegong Zhang; Tien Yin Wong; Bok-Ghee Han; Shotai Kobayashi; Toshio Ogihara; Dingliang Zhu; Naoharu Iwai; Jer-Yuarn Wu; Yik Ying Teo; E Shyong Tai; Yoon Shin Cho; Jiang He
Journal:  Nat Genet       Date:  2011-05-15       Impact factor: 38.330

Review 2.  Cyclosporine-A as a neuroprotective agent against stroke: its translation from laboratory research to clinical application.

Authors:  Mohamed M Osman; Dzenan Lulic; Loren Glover; Christine E Stahl; Tsz Lau; Harry van Loveren; Cesar V Borlongan
Journal:  Neuropeptides       Date:  2011-05-17       Impact factor: 3.286

3.  Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells.

Authors:  Kenichiro Koda; Mariselis Salazar-Rodriguez; Federico Corti; Noel Yan-Ki Chan; Racha Estephan; Randi B Silver; Daria Mochly-Rosen; Roberto Levi
Journal:  Circulation       Date:  2010-08-09       Impact factor: 29.690

4.  A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.

Authors:  Daniel F Gudbjartsson; Hilma Holm; Solveig Gretarsdottir; Gudmar Thorleifsson; G Bragi Walters; Gudmundur Thorgeirsson; Jeffrey Gulcher; Ellisiv B Mathiesen; Inger Njølstad; Audhild Nyrnes; Tom Wilsgaard; Erin M Hald; Kristian Hveem; Camilla Stoltenberg; Gayle Kucera; Tanya Stubblefield; Shannon Carter; Dan Roden; Maggie C Y Ng; Larry Baum; Wing Yee So; Ka Sing Wong; Juliana C N Chan; Christian Gieger; H-Erich Wichmann; Andreas Gschwendtner; Martin Dichgans; Gregor Kuhlenbäumer; Klaus Berger; E Bernd Ringelstein; Steve Bevan; Hugh S Markus; Konstantinos Kostulas; Jan Hillert; Sigurlaug Sveinbjörnsdóttir; Einar M Valdimarsson; Maja-Lisa Løchen; Ronald C W Ma; Dawood Darbar; Augustine Kong; David O Arnar; Unnur Thorsteinsdottir; Kari Stefansson
Journal:  Nat Genet       Date:  2009-07-13       Impact factor: 38.330

5.  Risk variants for atrial fibrillation on chromosome 4q25 associate with ischemic stroke.

Authors:  Solveig Gretarsdottir; Gudmar Thorleifsson; Andrei Manolescu; Unnur Styrkarsdottir; Anna Helgadottir; Andreas Gschwendtner; Konstantinos Kostulas; Gregor Kuhlenbäumer; Steve Bevan; Thorbjorg Jonsdottir; Hjordis Bjarnason; Jona Saemundsdottir; Stefan Palsson; David O Arnar; Hilma Holm; Gudmundur Thorgeirsson; Einar Mar Valdimarsson; Sigurlaug Sveinbjörnsdottir; Christian Gieger; Klaus Berger; H-Erich Wichmann; Jan Hillert; Hugh Markus; Jeffrey Robert Gulcher; E Bernd Ringelstein; Augustine Kong; Martin Dichgans; Daniel Fannar Gudbjartsson; Unnur Thorsteinsdottir; Kari Stefansson
Journal:  Ann Neurol       Date:  2008-10       Impact factor: 10.422

6.  Aldehyde dehydrogenase 2 ameliorates acute cardiac toxicity of ethanol: role of protein phosphatase and forkhead transcription factor.

Authors:  Heng Ma; Ji Li; Feng Gao; Jun Ren
Journal:  J Am Coll Cardiol       Date:  2009-12-01       Impact factor: 24.094

Review 7.  Finding the missing heritability of complex diseases.

Authors:  Teri A Manolio; Francis S Collins; Nancy J Cox; David B Goldstein; Lucia A Hindorff; David J Hunter; Mark I McCarthy; Erin M Ramos; Lon R Cardon; Aravinda Chakravarti; Judy H Cho; Alan E Guttmacher; Augustine Kong; Leonid Kruglyak; Elaine Mardis; Charles N Rotimi; Montgomery Slatkin; David Valle; Alice S Whittemore; Michael Boehnke; Andrew G Clark; Evan E Eichler; Greg Gibson; Jonathan L Haines; Trudy F C Mackay; Steven A McCarroll; Peter M Visscher
Journal:  Nature       Date:  2009-10-08       Impact factor: 49.962

8.  Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction.

Authors:  Thomas A Doser; Subat Turdi; D Paul Thomas; Paul N Epstein; Shi-Yan Li; Jun Ren
Journal:  Circulation       Date:  2009-03-30       Impact factor: 29.690

9.  Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.

Authors:  Matthew Traylor; Martin Farrall; Elizabeth G Holliday; Cathie Sudlow; Jemma C Hopewell; Yu-Ching Cheng; Myriam Fornage; M Arfan Ikram; Rainer Malik; Steve Bevan; Unnur Thorsteinsdottir; Mike A Nalls; Wt Longstreth; Kerri L Wiggins; Sunaina Yadav; Eugenio A Parati; Anita L Destefano; Bradford B Worrall; Steven J Kittner; Muhammad Saleem Khan; Alex P Reiner; Anna Helgadottir; Sefanja Achterberg; Israel Fernandez-Cadenas; Sherine Abboud; Reinhold Schmidt; Matthew Walters; Wei-Min Chen; E Bernd Ringelstein; Martin O'Donnell; Weang Kee Ho; Joanna Pera; Robin Lemmens; Bo Norrving; Peter Higgins; Marianne Benn; Michele Sale; Gregor Kuhlenbäumer; Alexander S F Doney; Astrid M Vicente; Hossein Delavaran; Ale Algra; Gail Davies; Sofia A Oliveira; Colin N A Palmer; Ian Deary; Helena Schmidt; Massimo Pandolfo; Joan Montaner; Cara Carty; Paul I W de Bakker; Konstantinos Kostulas; Jose M Ferro; Natalie R van Zuydam; Einar Valdimarsson; Børge G Nordestgaard; Arne Lindgren; Vincent Thijs; Agnieszka Slowik; Danish Saleheen; Guillaume Paré; Klaus Berger; Gudmar Thorleifsson; Albert Hofman; Thomas H Mosley; Braxton D Mitchell; Karen Furie; Robert Clarke; Christopher Levi; Sudha Seshadri; Andreas Gschwendtner; Giorgio B Boncoraglio; Pankaj Sharma; Joshua C Bis; Solveig Gretarsdottir; Bruce M Psaty; Peter M Rothwell; Jonathan Rosand; James F Meschia; Kari Stefansson; Martin Dichgans; Hugh S Markus
Journal:  Lancet Neurol       Date:  2012-10-05       Impact factor: 59.935

Review 10.  Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations.

Authors:  Giia-Sheun Peng; Shih-Jiun Yin
Journal:  Hum Genomics       Date:  2009-01       Impact factor: 4.639
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  6 in total

1.  Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system.

Authors:  Antje D Ebert; Kazuki Kodo; Ping Liang; Haodi Wu; Bruno C Huber; Johannes Riegler; Jared Churko; Jaecheol Lee; Patricia de Almeida; Feng Lan; Sebastian Diecke; Paul W Burridge; Joseph D Gold; Daria Mochly-Rosen; Joseph C Wu
Journal:  Sci Transl Med       Date:  2014-09-24       Impact factor: 17.956

2.  Alda-1 reduces cerebral ischemia/reperfusion injury in rat through clearance of reactive aldehydes.

Authors:  Si-Hai Fu; Hong-Feng Zhang; Zhong-Bao Yang; Ting-Bo Li; Bin Liu; Zheng Lou; Qi-Lin Ma; Xiu-Ju Luo; Jun Peng
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2013-10-01       Impact factor: 3.000

3.  Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.

Authors:  Shanshan Zhong; Luxiao Li; Yu-Lei Zhang; Lili Zhang; Jianhong Lu; Shuyuan Guo; Ningning Liang; Jing Ge; Mingjiang Zhu; Yongzhen Tao; Yun-Cheng Wu; Huiyong Yin
Journal:  J Clin Invest       Date:  2018-12-03       Impact factor: 14.808

Review 4.  Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics.

Authors:  Amir Ajoolabady; Shuyi Wang; Guido Kroemer; Josef M Penninger; Vladimir N Uversky; Domenico Pratico; Nils Henninger; Russel J Reiter; Askiel Bruno; Kaumudi Joshipura; Hamid Aslkhodapasandhokmabad; Daniel J Klionsky; Jun Ren
Journal:  Pharmacol Ther       Date:  2021-04-03       Impact factor: 13.400

5.  Genetic polymorphisms in the ALDH2 gene and the risk of ischemic stroke in a Chinese han population.

Authors:  Shuaiqi Sun; Jun He; Yao Zhang; Rongjun Xiao; Mengdan Yan; Yulin Ren; Yuanyuan Zhu; Tianbo Jin; Ying Xia
Journal:  Oncotarget       Date:  2017-10-10

6.  Aldehyde dehydrogenase 2 protects against acute kidney injury by regulating autophagy via the Beclin-1 pathway.

Authors:  Tonghui Xu; Jialin Guo; Maozeng Wei; Jiali Wang; Kehui Yang; Chang Pan; Jiaojiao Pang; Li Xue; Qiuhuan Yuan; Mengyang Xue; Jian Zhang; Wentao Sang; Tangxing Jiang; Yuguo Chen; Feng Xu
Journal:  JCI Insight       Date:  2021-08-09
  6 in total

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